메뉴 건너뛰기




Volumn 13, Issue 2, 2012, Pages 122-135

Biomolecular predictors of urothelial cancer behavior and treatment outcomes

Author keywords

Biomarker; Bladder cancer; Molecular marker; Prediction; Prognosis; Survival; Urothelial carcinoma

Indexed keywords

ANDROGEN RECEPTOR; BCG VACCINE; CASPASE 3; CISPLATIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; KI 67 ANTIGEN; MATRIX METALLOPROTEINASE; METHOTREXATE; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN P27; RETINOBLASTOMA PROTEIN; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VINBLASTINE;

EID: 84860770688     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-012-0237-1     Document Type: Review
Times cited : (48)

References (96)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • doi:10.3322/caac.20073.
    • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277-300. doi:10.3322/caac.20073.
    • (2010) CA Cancer J Clin. , vol.60 , Issue.5 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 2
    • 33748122712 scopus 로고    scopus 로고
    • Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder
    • discussion 61-2.
    • Karakiewicz PI, Shariat SF, Palapattu GS, Gilad AE, Lotan Y, Rogers CG, et al. Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder. J Urol. 2006;176(4 Pt 1):1354-61. discussion 61-2.
    • (2006) J Urol. , vol.176 , Issue.4 PART 1 , pp. 1354-1361
    • Karakiewicz, P.I.1    Shariat, S.F.2    Palapattu, G.S.3    Gilad, A.E.4    Lotan, Y.5    Rogers, C.G.6
  • 5
    • 84860774870 scopus 로고    scopus 로고
    • Can we apply nomograms derived in the United States to European patients?
    • (Epub ahead of print).
    • Rink M, Shariat SF. Can we apply nomograms derived in the United States to European patients? Yes, We Can! Eur Urol. 2011 (Epub ahead of print).
    • (2011) Yes, We Can! Eur Urol.
    • Rink, M.1    Shariat, S.F.2
  • 8
    • 77953817519 scopus 로고    scopus 로고
    • Statistical consideration for clinical biomarker research in bladder cancer
    • doi:10.1016/j.urolonc.2010.02.011.
    • Shariat SF, Lotan Y, Vickers A, Karakiewicz PI, Schmitz-Dräger BJ, Goebell PJ, et al. Statistical consideration for clinical biomarker research in bladder cancer. Urol Oncol. 2010;28(4):389-400. doi:10.1016/j.urolonc.2010.02. 011.
    • (2010) Urol Oncol. , vol.28 , Issue.4 , pp. 389-400
    • Shariat, S.F.1    Lotan, Y.2    Vickers, A.3    Karakiewicz, P.I.4    Schmitz-Dräger, B.J.5    Goebell, P.J.6
  • 9
    • 58149191585 scopus 로고    scopus 로고
    • Epigenetic markers as promising prognosticators for bladder cancer
    • doi:10.1111/ j.1442-2042.2008.02143.x.
    • Kim YK, Kim WJ. Epigenetic markers as promising prognosticators for bladder cancer. Int J Urol. 2009;16(1):17-22. doi:10.1111/ j.1442-2042.2008. 02143.x.
    • (2009) Int J Urol. , vol.16 , Issue.1 , pp. 17-22
    • Kim, Y.K.1    Kim, W.J.2
  • 10
    • 38049047956 scopus 로고    scopus 로고
    • Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy
    • doi:10.1002/cncr.23162.
    • Shariat SF, Karakiewicz PI, Ashfaq R, Lerner SP, Palapattu GS, Cote RJ, et al. Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy. Cancer. 2008;112(2):315-25. doi:10.1002/cncr.23162.
    • (2008) Cancer. , vol.112 , Issue.2 , pp. 315-325
    • Shariat, S.F.1    Karakiewicz, P.I.2    Ashfaq, R.3    Lerner, S.P.4    Palapattu, G.S.5    Cote, R.J.6
  • 11
    • 37349099709 scopus 로고    scopus 로고
    • Molecular markers in bladder cancer
    • DOI 10.1097/MOU.0b013e3282f1c5c1, PII 0004230720080100000002
    • Shariat SF, Karam JA, Lerner SP. Molecular markers in bladder cancer. Curr Opin Urol. 2008;18(1):1-8. doi:10.1097/ MOU.0b013e3282f1c5c1. (Pubitemid 350307522)
    • (2008) Current Opinion in Urology , vol.18 , Issue.1 , pp. 1-8
    • Shariat, S.F.1    Karam, J.A.2    Lerner, S.P.3
  • 12
    • 77950998537 scopus 로고    scopus 로고
    • Bladder cancer: Nomogram aids clinical decision making after radical cystectomy
    • Shariat SF, Tilki D. Bladder cancer: nomogram aids clinical decision making after radical cystectomy. Nat Rev Urol. 2010;7 (4):182-4.
    • (2010) Nat Rev Urol. , vol.7 , Issue.4 , pp. 182-184
    • Shariat, S.F.1    Tilki, D.2
  • 13
    • 62149132464 scopus 로고    scopus 로고
    • Molecular markers for detection, surveillance and prognostication of bladder cancer
    • doi:10.1111/j.1442-2042.2008.02225.x.
    • Vrooman OP, Witjes JA. Molecular markers for detection, surveillance and prognostication of bladder cancer. Int J Urol. 2009;16 (3):234-43. doi:10.1111/j.1442-2042.2008.02225.x.
    • (2009) Int J Urol. , vol.16 , Issue.3 , pp. 234-243
    • Vrooman, O.P.1    Witjes, J.A.2
  • 14
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • doi:10.1038/35042675.
    • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307-10. doi:10.1038/35042675.
    • (2000) Nature. , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 17
    • 1842457693 scopus 로고    scopus 로고
    • P53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer
    • DOI 10.1200/JCO.2004.03.118
    • Shariat SF, Tokunaga H, Zhou J, Kim J, Ayala GE, Benedict WF, et al. p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 2004;22(6):1014-24. doi:10.1200/jco.2004.03.118. (Pubitemid 41095033)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.6 , pp. 1014-1024
    • Shariat, S.F.1    Tokunaga, H.2    Zhou, J.3    Kim, J.4    Ayala, G.E.5    Benedict, W.F.6    Lerner, S.P.7
  • 19
    • 0027240177 scopus 로고
    • Genetic alterations in bladder cancer
    • DOI 10.1016/0140-6736(93)91595-D
    • Dalbagni G, Presti J, Reuter V, Fair WR, Cordon-Cardo C. Genetic alterations in bladder cancer. Lancet. 1993;342(8869):469-71. (Pubitemid 23240312)
    • (1993) Lancet , vol.342 , Issue.8869 , pp. 469-471
    • Dalbagni, G.1    Presti, J.2    Reuter, V.3    Fair, W.R.4    Cordon-Cardo, C.5
  • 22
    • 24044554230 scopus 로고    scopus 로고
    • P53 as a prognostic marker for bladder cancer: A meta-analysis and review
    • DOI 10.1016/S1470-2045(05)70315-6, PII S1470204505703156
    • Malats N, Bustos A, Nascimento CM, Fernandez F, Rivas M, Puente D, et al. P53 as a prognostic marker for bladder cancer: a meta-analysis and review. Lancet Oncol. 2005;6(9):678-86. doi:10.1016/s1470-2045(05)70315-6. (Pubitemid 41222758)
    • (2005) Lancet Oncology , vol.6 , Issue.9 , pp. 678-686
    • Malats, N.1    Bustos, A.2    Nascimento, C.M.3    Fernandez, F.4    Rivas, M.5    Puente, D.6    Kogevinas, M.7    Real, F.X.8
  • 23
    • 68149179652 scopus 로고    scopus 로고
    • P53 predictive value for pT1-2 N0 disease at radical cystectomy
    • doi:10.1016/j.juro.2009.05.024.
    • Shariat SF, Lotan Y, Karakiewicz PI, Ashfaq R, Isbarn H, Fradet Y, et al. p53 predictive value for pT1-2 N0 disease at radical cystectomy. J Urol. 2009;182(3):907-13. doi:10.1016/j.juro.2009.05.024.
    • (2009) J Urol. , vol.182 , Issue.3 , pp. 907-913
    • Shariat, S.F.1    Lotan, Y.2    Karakiewicz, P.I.3    Ashfaq, R.4    Isbarn, H.5    Fradet, Y.6
  • 24
    • 33947578925 scopus 로고    scopus 로고
    • Cooperative effect of cell-cycle regulators expression on bladder cancer development and biologic aggressiveness
    • DOI 10.1038/modpathol.3800757, PII 3800757
    • Shariat SF, Zlotta AR, Ashfaq R, Sagalowsky AI, Lotan Y. Cooperative effect of cell-cycle regulators expression on bladder cancer development and biologic aggressiveness. Mod Pathol. 2007;20 (4):445-59. doi:10.1038/modpathol. 3800757. (Pubitemid 46482368)
    • (2007) Modern Pathology , vol.20 , Issue.4 , pp. 445-459
    • Shariat, S.F.1    Zlotta, A.R.2    Ashfaq, R.3    Sagalowsky, A.I.4    Lotan, Y.5
  • 25
    • 76149145040 scopus 로고    scopus 로고
    • P53 expression in patients with advanced urothelial cancer of the urinary bladder
    • doi:10.1111/j.1464-410X.2009.08742.x.
    • Shariat SF, Bolenz C, Karakiewicz PI, Fradet Y, Ashfaq R, Bastian PJ, et al. p53 expression in patients with advanced urothelial cancer of the urinary bladder. BJU Int. 2010;105(4):489-95. doi:10.1111/j.1464-410X.2009.08742.x.
    • (2010) BJU Int. , vol.105 , Issue.4 , pp. 489-495
    • Shariat, S.F.1    Bolenz, C.2    Karakiewicz, P.I.3    Fradet, Y.4    Ashfaq, R.5    Bastian, P.J.6
  • 26
    • 71249096845 scopus 로고    scopus 로고
    • Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer
    • doi:10.1016/j.juro.2009.08.115.
    • •• Shariat SF, Chade DC, Karakiewicz PI, Ashfaq R, Isbarn H, Fradet Y et al. Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer. J Urol. 2010;183(1):68-75. doi:10.1016/j.juro.2009.08.115. This study demonstrates the importance of using a combination of molecular markers for molecular staging, prognostication, and prediction of response to therapy. While status of individual molecular cell-cycle markers did not add sufficient value to outcome prediction in patients with advanced UCB, a combination of four markers was able to significantly improve prognostications.
    • (2010) J Urol. , vol.183 , Issue.1 , pp. 68-75
    • Shariat, S.F.1    Chade, D.C.2    Karakiewicz, P.I.3    Ashfaq, R.4    Isbarn, H.5    Fradet, Y.6
  • 27
    • 67349241506 scopus 로고    scopus 로고
    • Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy
    • discussion doi:10.1016/j.juro.2009.02.125.
    • Shariat SF, Bolenz C, Godoy G, Fradet Y, Ashfaq R, Karakiewicz PI et al. Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy. J Urol. 2009;182(1):78-84; discussion doi:10.1016/j.juro.2009.02.125.
    • (2009) J Urol. , vol.182 , Issue.1 , pp. 78-84
    • Shariat, S.F.1    Bolenz, C.2    Godoy, G.3    Fradet, Y.4    Ashfaq, R.5    Karakiewicz, P.I.6
  • 28
    • 77953815362 scopus 로고    scopus 로고
    • P53 immunohistochemistry in bladder cancer - A new approach to an old question
    • (ISBC) IS-IoBC. doi:10.1016/j.urolonc.2010.03.021.
    • • Goebell PJ, Groshen SG, Schmitz-Dräger BJ, (ISBC) IS-IoBC. p53 immunohistochemistry in bladder cancer-a new approach to an old question. Urol Oncol. 2010;28(4):377-88. doi:10.1016/j.urolonc.2010.03.021. This large study comprising 3,421 patients demonstrates the value of p53 immunohistochemistry in prognostication of UCB >pT1. The results of this trial demonstrate the relevance of sufficient study size, provide a basis to define suitable patient populations, and allow an estimation of an adequate size of study cohorts for prospective trials.
    • (2010) Urol Oncol. , vol.28 , Issue.4 , pp. 377-388
    • Goebell, P.J.1    Groshen, S.G.2    Schmitz-Dräger, B.J.3
  • 29
    • 33846262187 scopus 로고    scopus 로고
    • Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladder
    • DOI 10.1111/j.1464-410X.2006.06624.x
    • Dalbagni G, Parekh DJ, Ben-Porat L, Potenzoni M, Herr HW, Reuter VE. Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladder. BJU Int. 2007;99 (2):281-5. doi:10.1111/j.1464-410X. 2006.06624.x. (Pubitemid 46103104)
    • (2007) BJU International , vol.99 , Issue.2 , pp. 281-285
    • Dalbagni, G.1    Parekh, D.J.2    Ben-Porat, L.3    Potenzoni, M.4    Herr, H.W.5    Reuter, V.E.6
  • 30
    • 33947209498 scopus 로고    scopus 로고
    • Predictive value of p53 and pRb expression in superficial bladder cancer patients treated with BCG and interferon-alpha
    • DOI 10.1002/cncr.22503
    • Esuvaranathan K, Chiong E, Thamboo TP, Chan YH, Kamaraj R, Mahendran R, et al. Predictive value of p53 and pRb expression in superficial bladder cancer patients treated with BCG and interferon-alpha. Cancer. 2007;109(6):1097-105. doi:10.1002/ cncr.22503. (Pubitemid 46435388)
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1097-1105
    • Esuvaranathan, K.1    Chiong, E.2    Thamboo, T.P.3    Chan, Y.H.4    Kamaraj, R.5    Mahendran, R.6    Teh, M.7
  • 31
    • 33845304992 scopus 로고    scopus 로고
    • Prognostic value of p53 for high risk superficial bladder cancer with long-term followup
    • DOI 10.1016/j.juro.2006.08.110, PII S0022534706021495
    • Moonen PM, van Balken-Ory B, Kiemeney LA, Schalken JA, Witjes JA. Prognostic value of p53 for high risk superficial bladder cancer with long-term followup. J Urol. 2007;177(1):80-3. doi:10.1016/j.juro.2006.08.110. (Pubitemid 44879442)
    • (2007) Journal of Urology , vol.177 , Issue.1 , pp. 80-83
    • Moonen, P.M.J.1    Van Balken-Ory, B.2    Kiemeney, L.A.L.M.3    Schalken, J.A.4    Witjes, J.A.5
  • 32
    • 71949095084 scopus 로고    scopus 로고
    • Altered p53 and pRb expression is predictive of response to BCG treatment in T1G3 bladder cancer
    • Cormio L, Tolve I, Annese P, Saracino A, Zamparese R, Sanguedolce F, et al. Altered p53 and pRb expression is predictive of response to BCG treatment in T1G3 bladder cancer. Anticancer Res. 2009;29 (10):4201-4.
    • (2009) Anticancer Res. , vol.29 , Issue.10 , pp. 4201-4204
    • Cormio, L.1    Tolve, I.2    Annese, P.3    Saracino, A.4    Zamparese, R.5    Sanguedolce, F.6
  • 33
    • 79953793155 scopus 로고    scopus 로고
    • A six-week course of bacillus Calmette-Guerin prophylaxis is insufficient to prevent tumor recurrence in nonmuscle invasive bladder cancer with strong-positive expression of p53
    • Oh JJ, Ji SH, Choi DK, Gong IH, Kim TH, Park DS. A six-week course of bacillus Calmette-Guerin prophylaxis is insufficient to prevent tumor recurrence in nonmuscle invasive bladder cancer with strong-positive expression of p53. Oncology. 2010;79(5- 6):440-6.
    • (2010) Oncology. , vol.79 , Issue.5-6 , pp. 440-446
    • Oh, J.J.1    Ji, S.H.2    Choi, D.K.3    Gong, I.H.4    Kim, T.H.5    Park, D.S.6
  • 34
    • 84860705285 scopus 로고    scopus 로고
    • Do molecular biomarkers have prognostic value in primary T1G3 bladder cancer treated with bacillus Calmette-Guerin intravesical therapy?
    • • Park J, Song C, Shin E, Hong JH, Kim CS, Ahn H. Do molecular biomarkers have prognostic value in primary T1G3 bladder cancer treated with bacillus Calmette-Guerin intravesical therapy? Urol Oncol. 2011. This is one of only few studies failing to show an influence of seven different biomarkers on prognostication in 61 pT1G3 UCB patients with a primary BCG treatment. This study is an important example of the difficulties in evaluating biomarkers in UCB.
    • (2011) Urol Oncol.
    • Park, J.1    Song, C.2    Shin, E.3    Hong, J.H.4    Kim, C.S.5    Ahn, H.6
  • 35
    • 80052737876 scopus 로고    scopus 로고
    • Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status
    • •• Stadler WM, Lerner SP, Groshen S, Stein JP, Shi SR, Raghavan D et al. Phase III Study of Molecularly Targeted Adjuvant Therapy in Locally Advanced Urothelial Cancer of the Bladder Based on p53 Status. J Clin Oncol. 2011. This is the first study reporting a prospective randomized controlled trial assessing the impact of p53 on outcomes of pT1/T2/N0M0 UCB treated with adjuvant chemotherapy. The study demonstrated no difference in disease outcome or benefit of chemotherapy according to the biomarker status.
    • (2011) J Clin Oncol.
    • Stadler, W.M.1    Lerner, S.P.2    Groshen, S.3    Stein, J.P.4    Shi, S.R.5    Raghavan, D.6
  • 36
    • 33846206414 scopus 로고    scopus 로고
    • Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease
    • DOI 10.1158/1078-0432.CCR-06-1472
    • Margulis V, Shariat SF, Ashfaq R, Sagalowsky AI, Lotan Y. Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease. Clin Cancer Res. 2006;12(24):7369-73. (Pubitemid 46095410)
    • (2006) Clinical Cancer Research , vol.12 , Issue.24 , pp. 7369-7373
    • Margulis, V.1    Shariat, S.F.2    Ashfaq, R.3    Sagalowsky, A.I.4    Lotan, Y.5
  • 37
    • 59049085842 scopus 로고    scopus 로고
    • Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer
    • doi:10.1093/jnci/ djn451.
    • •• Margulis V, Lotan Y, Karakiewicz PI, Fradet Y, Ashfaq R, Capitanio U et al. Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer. J Natl Cancer Inst. 2009;101(2):114-9. doi:10.1093/jnci/ djn451. In this large study of 713 patients treated with RC, Ki-67 labeling index was independently associated with aggressive pathological features and worse disease outcome. This marker holds the potential for a better patient stratification for perioperative chemotherapy.
    • (2009) J Natl Cancer Inst. , vol.101 , Issue.2 , pp. 114-119
    • Margulis, V.1    Lotan, Y.2    Karakiewicz, P.I.3    Fradet, Y.4    Ashfaq, R.5    Capitanio, U.6
  • 38
    • 84860705286 scopus 로고    scopus 로고
    • Expression of cell cycle-associated proteins in nonmuscle- invasive bladder cancer: Correlation with intravesical recurrence following transurethral resection
    • Behnsawy HM, Miyake H, Abdalla MA, Sayed MA, Ahmed AE, Fujisawa M. Expression of cell cycle-associated proteins in nonmuscle- invasive bladder cancer: Correlation with intravesical recurrence following transurethral resection. Urol Oncol. 2009.
    • (2009) Urol Oncol.
    • Behnsawy, H.M.1    Miyake, H.2    Abdalla, M.A.3    Sayed, M.A.4    Ahmed, A.E.5    Fujisawa, M.6
  • 39
    • 39349098773 scopus 로고    scopus 로고
    • Survivin: A promising biomarker for detection and prognosis of bladder cancer
    • doi:10.1007/s00345-007-0219-y.
    • Margulis V, Lotan Y, Shariat SF. Survivin: a promising biomarker for detection and prognosis of bladder cancer. World J Urol. 2008;26(1):59-65. doi:10.1007/s00345-007-0219-y.
    • (2008) World J Urol. , vol.26 , Issue.1 , pp. 59-65
    • Margulis, V.1    Lotan, Y.2    Shariat, S.F.3
  • 40
    • 16444381574 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cleaved caspase-3 detects high level of apoptosis frequently in diffuse large B-cell lymphomas of the central nervous system
    • DOI 10.1111/j.1440-1827.2005.01808.x
    • Arai M, Sasaki A, Saito N, Nakazato Y. Immunohistochemical analysis of cleaved caspase-3 detects high level of apoptosis frequently in diffuse large B-cell lymphomas of the central nervous system. Pathol Int. 2005;55(3):122-9. doi:10.1111/j.1440- 1827.2005.01808.x. (Pubitemid 40477223)
    • (2005) Pathology International , vol.55 , Issue.3 , pp. 122-129
    • Arai, M.1    Sasaki, A.2    Saito, N.3    Nakazato, Y.4
  • 41
    • 33846469888 scopus 로고    scopus 로고
    • Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy
    • DOI 10.1016/S1470-2045(07)70002-5, PII S1470204507700025
    • Karam JA, Lotan Y, Karakiewicz PI, Ashfaq R, Sagalowsky AI, Roehrborn CG, et al. Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy. Lancet Oncol. 2007;8(2):128-36. doi:10.1016/S1470- 2045(07)70002-5. (Pubitemid 46158371)
    • (2007) Lancet Oncology , vol.8 , Issue.2 , pp. 128-136
    • Karam, J.A.1    Lotan, Y.2    Karakiewicz, P.I.3    Ashfaq, R.4    Sagalowsky, A.I.5    Roehrborn, C.G.6    Shariat, S.F.7
  • 42
    • 0346250160 scopus 로고    scopus 로고
    • Survivin, versatile modulation of cell division and apoptosis in cancer
    • DOI 10.1038/sj.onc.1207113
    • Altieri DC. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene. 2003;22(53):8581-9. doi:10.1038/ sj.onc.1207113. (Pubitemid 38019195)
    • (2003) Oncogene , vol.22 , Issue.53 REV. ISS. 7 , pp. 8581-8589
    • Altieri, D.C.1
  • 44
    • 0345868325 scopus 로고    scopus 로고
    • Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer
    • DOI 10.1097/01.ju.0000107826.78479.90
    • Shariat SF, Casella R, Khoddami SM, Hernandez G, Sulser T, Gasser TC, et al. Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer. J Urol. 2004;171 (2 Pt 1):626-30. doi:10.1097/01.ju.0000107826.78479.90. (Pubitemid 38090444)
    • (2004) Journal of Urology , vol.171 , Issue.2 , pp. 626-630
    • Shariat, S.F.1    Casella, R.2    Khoddami, S.M.3    Hernandez, G.4    Sulser, T.5    Gasser, T.C.6    Lerner, S.P.7
  • 46
    • 33947254466 scopus 로고    scopus 로고
    • Survivin expression is associated with bladder cancer presence, stage, progression, and mortality
    • DOI 10.1002/cncr.22521
    • Shariat SF, Ashfaq R, Karakiewicz PI, Saeedi O, Sagalowsky AI, Lotan Y. Survivin expression is associated with bladder cancer presence, stage, progression, and mortality. Cancer. 2007;109 (6):1106-13. doi:10.1002/cncr. 22521. (Pubitemid 46435389)
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1106-1113
    • Shariat, S.F.1    Ashfaq, R.2    Karakiewicz, P.I.3    Saeedi, O.4    Sagalowsky, A.I.5    Lotan, Y.6
  • 47
    • 72549108606 scopus 로고    scopus 로고
    • Survivin as a prognostic marker for urothelial carcinoma of the bladder: A multicenter external validation study
    • doi:10.1158/1078-0432.ccr-08-2554
    • •• Shariat SF, Karakiewicz PI, Godoy G, Karam JA, Ashfaq R, Fradet Y et al. Survivin as a prognostic marker for urothelial carcinoma of the bladder: a multicenter external validation study. Clin Cancer Res. 2009;15(22):7012-9. doi:10.1158/1078-0432.ccr-08-2554. This large external validation study demonstrates the value of survivin expression for an improved prediction of cancer recurrence and survival in patients with pT1-3N0M0 UCB.
    • (2009) Clin Cancer Res. , vol.15 , Issue.22 , pp. 7012-7019
    • Shariat, S.F.1    Karakiewicz, P.I.2    Godoy, G.3    Karam, J.A.4    Ashfaq, R.5    Fradet, Y.6
  • 49
    • 77950518406 scopus 로고    scopus 로고
    • Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers
    • doi:10.1016/j.juro.2010.01.018.
    • Shariat SF, Youssef RF, Gupta A, Chade DC, Karakiewicz PI, Isbarn H, et al. Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers. J Urol. 2010;183(5):1744-50. doi:10.1016/j.juro.2010. 01.018.
    • (2010) J Urol. , vol.183 , Issue.5 , pp. 1744-1750
    • Shariat, S.F.1    Youssef, R.F.2    Gupta, A.3    Chade, D.C.4    Karakiewicz, P.I.5    Isbarn, H.6
  • 51
    • 35348944486 scopus 로고    scopus 로고
    • VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: Relationships to clinicopathological parameters and long-term survival
    • Herrmann E, Eltze E, Bierer S, Kopke T, Gorge T, Neumann J, et al. VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: relationships to clinicopathological parameters and long-term survival. Anticancer Res. 2007;27(5A):3127-33. (Pubitemid 47607535)
    • (2007) Anticancer Research , vol.27 , Issue.5 A , pp. 3127-3133
    • Herrmann, E.1    Eltze, E.2    Bierer, S.3    Kopke, T.4    Gorge, T.5    Neumann, J.6    Hertle, L.7    Wulfing, C.8
  • 52
    • 32944469620 scopus 로고    scopus 로고
    • Lymphangiogenesis and angiogenesis in bladder cancer: Prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D
    • DOI 10.1158/1078-0432.CCR-05-1284
    • Miyata Y, Kanda S, Ohba K, Nomata K, Hayashida Y, Eguchi J, et al. Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D. Clin Cancer Res. 2006;12(3 Pt 1):800-6. doi:10.1158/1078-0432.ccr-05-1284. (Pubitemid 43259860)
    • (2006) Clinical Cancer Research , vol.12 , Issue.3 , pp. 800-806
    • Miyata, Y.1    Kanda, S.2    Ohba, K.3    Nomata, K.4    Hayashida, Y.5    Eguchi, J.6    Hayashi, T.7    Kanetake, H.8
  • 53
    • 33749578614 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis
    • DOI 10.1111/j.1464-410X.2006.06446.x
    • Zu X, Tang Z, Li Y, Gao N, Ding J, Qi L. Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis. BJU Int. 2006;98 (5):1090-3. doi:10.1111/j.1464-410X. 2006.06446.x. (Pubitemid 44536464)
    • (2006) BJU International , vol.98 , Issue.5 , pp. 1090-1093
    • Zu, X.1    Tang, Z.2    Li, Y.3    Gao, N.4    Ding, J.5    Qi, L.6
  • 54
    • 65349189892 scopus 로고    scopus 로고
    • Targeting angiogenesis in bladder cancer
    • Elfiky AA, Rosenberg JE. Targeting angiogenesis in bladder cancer. Curr Oncol Rep. 2009;11(3):244-9.
    • (2009) Curr Oncol Rep. , vol.11 , Issue.3 , pp. 244-249
    • Elfiky, A.A.1    Rosenberg, J.E.2
  • 55
    • 59249093638 scopus 로고    scopus 로고
    • Molecular pathogenesis and diagnostics of bladder cancer
    • Mitra AP, Cote RJ. Molecular pathogenesis and diagnostics of bladder cancer. Annu Rev Pathol. 2009;4:251-85.
    • (2009) Annu Rev Pathol. , vol.4 , pp. 251-285
    • Mitra, A.P.1    Cote, R.J.2
  • 56
    • 36248943079 scopus 로고    scopus 로고
    • Role of FGFR3 in urothelial cell carcinoma: Biomarker and potential therapeutic target
    • doi:10.1007/s00345-007-0213-4.
    • Knowles MA. Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target. World J Urol. 2007;25 (6):581-93. doi:10.1007/s00345-007-0213-4.
    • (2007) World J Urol. , vol.25 , Issue.6 , pp. 581-593
    • Knowles, M.A.1
  • 57
    • 77955508884 scopus 로고    scopus 로고
    • Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer
    • van Rhijn BW, Zuiverloon TC, Vis AN, Radvanyi F, van Leenders GJ, Ooms BC, et al. Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer. Eur Urol. 2010;58(3):433-41.
    • (2010) Eur Urol. , vol.58 , Issue.3 , pp. 433-441
    • Van Rhijn, B.W.1    Zuiverloon, T.C.2    Vis, A.N.3    Radvanyi, F.4    Van Leenders, G.J.5    Ooms, B.C.6
  • 59
    • 79953797516 scopus 로고    scopus 로고
    • Use of standard markers and incorporation of molecular markers into breast cancer therapy: Consensus recommendations from an International Expert Panel
    • Kaufmann M, Pusztai L. Use of standard markers and incorporation of molecular markers into breast cancer therapy: Consensus recommendations from an International Expert Panel. Cancer. 2011;117(8):1575-82.
    • (2011) Cancer. , vol.117 , Issue.8 , pp. 1575-1582
    • Kaufmann, M.1    Pusztai, L.2
  • 63
    • 77951471947 scopus 로고    scopus 로고
    • Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients
    • Lae M, Couturier J, Oudard S, Radvanyi F, Beuzeboc P, Vieillefond A. Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients. Ann Oncol. 2010;21 (4):815-9.
    • (2010) Ann Oncol. , vol.21 , Issue.4 , pp. 815-819
    • Lae, M.1    Couturier, J.2    Oudard, S.3    Radvanyi, F.4    Beuzeboc, P.5    Vieillefond, A.6
  • 64
    • 79959556990 scopus 로고    scopus 로고
    • Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours
    • •• Fleischmann A, Rotzer D, Seiler R, Studer UE, Thalmann GN. Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours. Eur Urol. 2011;60(2):350-7. According to the results of this study, a targeted anti-HER2 therapy might have a greater potential in patients with metastatic disease than in patients with localized UCB. Furthermore, it is important to notice that HER2 expression is higher in metastatic sites and, therefore, analysis of primary tumor specimens might offer only an invalid picture of HER2 status.
    • (2011) Eur Urol. , vol.60 , Issue.2 , pp. 350-357
    • Fleischmann, A.1    Rotzer, D.2    Seiler, R.3    Studer, U.E.4    Thalmann, G.N.5
  • 65
    • 77957135510 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 expression status provides independent prognostic information in patients with urothelial carcinoma of the urinary bladder
    • doi:10.1111/j.1464-410X.2009.09190.x.
    • Bolenz C, Shariat SF, Karakiewicz PI, Ashfaq R, Ho R, Sagalowsky AI, et al. Human epidermal growth factor receptor 2 expression status provides independent prognostic information in patients with urothelial carcinoma of the urinary bladder. BJU Int. 2010;106(8):1216-22. doi:10.1111/j.1464-410X.2009. 09190.x.
    • (2010) BJU Int. , vol.106 , Issue.8 , pp. 1216-1222
    • Bolenz, C.1    Shariat, S.F.2    Karakiewicz, P.I.3    Ashfaq, R.4    Ho, R.5    Sagalowsky, A.I.6
  • 66
    • 4143086158 scopus 로고    scopus 로고
    • Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer
    • DOI 10.1016/j.urology.2004.03.025, PII S0090429504003425
    • Boorjian S, Ugras S, Mongan NP, Gudas LJ, You X, Tickoo SK, et al. Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology. 2004;64(2):383-8. doi:10.1016/j.urology.2004.03. 025. (Pubitemid 39092488)
    • (2004) Urology , vol.64 , Issue.2 , pp. 383-388
    • Boorjian, S.1    Ugras, S.2    Mongan, N.P.3    Gudas, L.J.4    You, X.5    Tickoo, S.K.6    Scherr, D.S.7
  • 67
    • 78650679920 scopus 로고    scopus 로고
    • Sex-specific hormone receptors in urothelial carcinomas of the human urinary bladder: A comparative analysis of clinicopathological features and survival outcomes according to receptor expression
    • doi:10.1016/j.urolonc.2009.01.033.
    • • Tuygun C, Kankaya D, Imamoglu A, Sertcelik A, Zengin K, Oktay M et al. Sex-specific hormone receptors in urothelial carcinomas of the human urinary bladder: a comparative analysis of clinicopathological features and survival outcomes according to receptor expression. Urol Oncol. 2011;29(1):43-51. doi:10.1016/j.urolonc.2009.01.033. Only few studies investigated the value of sex hormonal receptors with respect to gender differences in UCB outcomes. This study investigated altered marker level of the androgen and estrogen-β receptor.
    • (2011) Urol Oncol. , vol.29 , Issue.1 , pp. 43-51
    • Tuygun, C.1    Kankaya, D.2    Imamoglu, A.3    Sertcelik, A.4    Zengin, K.5    Oktay, M.6
  • 68
    • 79959286044 scopus 로고    scopus 로고
    • Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: A large multi-institutional study
    • Mir C, Shariat SF, van der Kwast TH, Ashfaq R, Lotan Y, Evans A, et al. Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study. BJU Int. 2011;108(1):24-30.
    • (2011) BJU Int. , vol.108 , Issue.1 , pp. 24-30
    • Mir, C.1    Shariat, S.F.2    Van Der Kwast, T.H.3    Ashfaq, R.4    Lotan, Y.5    Evans, A.6
  • 69
    • 70350564225 scopus 로고    scopus 로고
    • Estrogen and progesterone hormonal receptor expression in urothelial carcinoma of the bladder
    • doi:10.1016/j.eururo.2009.06.032.
    • Bolenz C, Lotan Y, Ashfaq R, Shariat SF. Estrogen and progesterone hormonal receptor expression in urothelial carcinoma of the bladder. Eur Urol. 2009;56(6):1093-5. doi:10.1016/j.eururo.2009.06.032.
    • (2009) Eur Urol. , vol.56 , Issue.6 , pp. 1093-1095
    • Bolenz, C.1    Lotan, Y.2    Ashfaq, R.3    Shariat, S.F.4
  • 70
    • 33745187848 scopus 로고    scopus 로고
    • Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue
    • doi:10.1002/cncr.21945.
    • Shen SS, Smith CL, Hsieh JT, Yu J, Kim IY, Jian W, et al. Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue. Cancer. 2006;106 (12):2610-6. doi:10.1002/cncr.21945.
    • (2006) Cancer. , vol.106 , Issue.12 , pp. 2610-2616
    • Shen, S.S.1    Smith, C.L.2    Hsieh, J.T.3    Yu, J.4    Kim, I.Y.5    Jian, W.6
  • 71
    • 57449117393 scopus 로고    scopus 로고
    • Combination of cell cycle regulating bio-markers improves prognosis in patients with organ-confined urothelial carcinoma at radical cystectomy
    • Shariat SF, Karakiewicz PI, Ashfaq R, Isbarn H, Fradet Y, Bastian PJ, et al. Combination of cell cycle regulating bio-markers improves prognosis in patients with organ-confined urothelial carcinoma at radical cystectomy. J Urol. 2008;179(4):578.
    • (2008) J Urol. , vol.179 , Issue.4 , pp. 578
    • Shariat, S.F.1    Karakiewicz, P.I.2    Ashfaq, R.3    Isbarn, H.4    Fradet, Y.5    Bastian, P.J.6
  • 72
    • 0037289762 scopus 로고    scopus 로고
    • Correlation of preoperative plasma levels of IGF-I and IGFBP-3 with pathologic parameters and clinical outcome in patients with bladder cancer
    • DOI 10.1016/S0090-4295(02)02253-7
    • Shariat SF, Kim J, Nguyen C, Wheeler TM, Lerner SP, Slawin KM. Correlation of preoperative levels of IGF-I and IGFBP-3 with pathologic parameters and clinical outcome in patients with bladder cancer. Urology. 2003;61(2):359-64. (Pubitemid 36206533)
    • (2003) Urology , vol.61 , Issue.2 , pp. 359-364
    • Shariat, S.F.1    Kim, J.2    Nguyen, C.3    Wheeler, T.M.4    Lerner, S.P.5    Slawin, K.M.6
  • 73
    • 0035051814 scopus 로고    scopus 로고
    • E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term follow-up
    • Byrne RR, Shariat SF, Brown R, Kattan MW, Morton Jr RA, Wheeler TM, et al. E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup. J Urol. 2001;165(5):1473-9. (Pubitemid 32410217)
    • (2001) Journal of Urology , vol.165 , Issue.5 , pp. 1473-1479
    • Byrne, R.R.1    Shariat, S.F.2    Brown, R.3    Kattan, M.W.4    Morton Jr., R.A.5    Wheeler, T.M.6    Lerner, S.P.7
  • 74
    • 0037963311 scopus 로고    scopus 로고
    • Association of plasma urokinase-type plasminogen activator and its receptor with clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder
    • DOI 10.1016/S0090-4295(02)02522-0
    • Shariat SF, Monoski MA, Andrews B, Wheeler TM, Lerner SP, Slawin KM. Association of plasma urokinase-type plasminogen activator and its receptor with clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder. Urology. 2003;61(5):1053-8. (Pubitemid 36547769)
    • (2003) Urology , vol.61 , Issue.5 , pp. 1053-1058
    • Shariat, S.F.1    Monoski, M.A.2    Andrews, B.3    Wheeler, T.M.4    Lerner, S.P.5    Slawin, K.M.6
  • 75
    • 0036160521 scopus 로고    scopus 로고
    • Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer
    • Andrews B, Shariat SF, Kim J-H, Wheeler TM, Slawin KM, Lerner SP. Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer. J Urol. 2002;167(3):1475-81. (Pubitemid 34132135)
    • (2002) Journal of Urology , vol.167 , Issue.3 , pp. 1475-1481
    • Andrews, B.1    Shariat, S.F.2    Kim, J.-H.3    Wheeler, T.M.4    Slawin, K.M.5    Lerner, S.P.6
  • 76
    • 0035883531 scopus 로고    scopus 로고
    • 1 and its receptors in transitional cell carcinoma of the urinary bladder
    • DOI 10.1002/1097-0142(20010915)92:6<1475::AID-CNCR1472>3.0.CO;2-X
    • Kim JH, Shariat SF, Kim IY, Menesses-Diaz A, Tokunaga H, Wheeler TM, et al. Predictive value of expression of transforming growth factor-beta(1) and its receptors in transitional cell carcinoma of the urinary bladder. Cancer. 2001;92(6):1475-83. (Pubitemid 32947832)
    • (2001) Cancer , vol.92 , Issue.6 , pp. 1475-1483
    • Kim, J.-H.1    Shariat, S.F.2    Kim, I.Y.3    Menesses-Diaz, A.4    Tokunaga, H.5    Wheeler, T.M.6    Lerner, S.P.7
  • 77
    • 0035892767 scopus 로고    scopus 로고
    • Preoperative plasma levels of transforming growth factor β1 strongly predict clinical outcome in patients with bladder carcinoma
    • DOI 10.1002/1097-0142(20011215)92:12<2985::AID-CNCR10175>3.0.CO;2-5
    • Shariat SF, Kim JH, Andrews B, Kattan MW, Wheeler TM, Kim IY, et al. Preoperative plasma levels of transforming growth factor beta(1) strongly predict clinical outcome in patients with bladder carcinoma. Cancer. 2001;92(12):2985-92. (Pubitemid 33136192)
    • (2001) Cancer , vol.92 , Issue.12 , pp. 2985-2992
    • Shariat, S.F.1    Kim, J.-H.2    Andrews, B.3    Kattan, M.W.4    Wheeler, T.M.5    Kim, I.Y.6    Lerner, S.P.7    Slawin, K.M.8
  • 81
    • 63849229054 scopus 로고    scopus 로고
    • Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells
    • doi:10.1182/blood-2008-08-172742.
    • Ito T-K, Ishii G, Saito S, Yano K, Hoshino A, Suzuki T, et al. Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells. Blood. 2009;113(10):2363-9. doi:10.1182/blood-2008-08-172742.
    • (2009) Blood. , vol.113 , Issue.10 , pp. 2363-2369
    • Ito, T.-K.1    Ishii, G.2    Saito, S.3    Yano, K.4    Hoshino, A.5    Suzuki, T.6
  • 82
    • 0037380202 scopus 로고    scopus 로고
    • Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder
    • DOI 10.1016/S0090-4295(02)02429-9
    • Guan K-P, Ye H-Y, Yan Z, Wang Y, Hou S-K. Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder. Urology. 2003;61(4):719-23. (Pubitemid 36384961)
    • (2003) Urology , vol.61 , Issue.4 , pp. 719-723
    • Guan, K.-P.1    Ye, H.-Y.2    Yan, Z.3    Wang, Y.4    Hou, S.-K.5
  • 83
    • 0242495736 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 immunoreactive protein as a prognostic marker in bladder cancer
    • DOI 10.1016/S0090-4295(03)00660-5
    • Vasala K, Pääkkö P, Turpeenniemi-Hujanen T. Matrix metalloproteinase-2 immunoreactive protein as a prognostic marker in bladder cancer. Urology. 2003;62(5):952-7. (Pubitemid 37421256)
    • (2003) Urology , vol.62 , Issue.5 , pp. 952-957
    • Vasala, K.1    Paakko, P.2    Turpeenniemi-Hujanen, T.3
  • 84
    • 77957163734 scopus 로고    scopus 로고
    • A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancerrelated death among patients with bladder cancer
    • doi:10.1002/cncr.25401
    • •• Svatek RS, Shah JB, Xing J, Chang D, Lin J, Mcconkey DJ et al. A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancerrelated death among patients with bladder cancer. Cancer. 2010;116(19):4513-9. doi:10.1002/cncr.25401. This study suggests that MMP-7 can help stratify patients for neoadjuvant or adjuvant treatment. Plasma levels of MMP-7 were significantly associated with cancer-specific survival.
    • (2010) Cancer. , vol.116 , Issue.19 , pp. 4513-4519
    • Svatek, R.S.1    Shah, J.B.2    Xing, J.3    Chang, D.4    Lin, J.5    McConkey, D.J.6
  • 85
    • 77953182449 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7 as a marker of metastasis and predictor of poor survival in bladder cancer
    • doi:10.1111/j.1349-7006.2010.01506.x.
    • Szarvas T, Becker M, Vom Dorp F, Gethmann C, Tötsch M, Bánkfalvi A, et al. Matrix metalloproteinase-7 as a marker of metastasis and predictor of poor survival in bladder cancer. Cancer Sci. 2010;101(5):1300-8. doi:10.1111/j.1349-7006.2010.01506.x.
    • (2010) Cancer Sci. , vol.101 , Issue.5 , pp. 1300-1308
    • Szarvas, T.1    Becker, M.2    Vom Dorp, F.3    Gethmann, C.4    Tötsch, M.5    Bánkfalvi, A.6
  • 86
    • 78549286948 scopus 로고    scopus 로고
    • Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancer
    • Szarvas T, Singer BB, Becker M, Vom Dorp F, Jager T, Szendroi A, et al. Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancer. BJU Int. 2011;107(7):1069-73.
    • (2011) BJU Int. , vol.107 , Issue.7 , pp. 1069-1073
    • Szarvas, T.1    Singer, B.B.2    Becker, M.3    Vom Dorp, F.4    Jager, T.5    Szendroi, A.6
  • 87
    • 80051668046 scopus 로고    scopus 로고
    • Validation of circulating MMP-7 level as an independent prognostic marker of poor survival in urinary bladder cancer
    • Szarvas T, Jager T, Becker M, Tschirdewahn S, Niedworok C, Kovalszky I, et al. Validation of circulating MMP-7 level as an independent prognostic marker of poor survival in urinary bladder cancer. Pathol Oncol Res. 2011;17(2):325-32.
    • (2011) Pathol Oncol Res. , vol.17 , Issue.2 , pp. 325-332
    • Szarvas, T.1    Jager, T.2    Becker, M.3    Tschirdewahn, S.4    Niedworok, C.5    Kovalszky, I.6
  • 89
    • 58149165081 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
    • de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2008;14(19):6302-9.
    • (2008) Clin Cancer Res. , vol.14 , Issue.19 , pp. 6302-6309
    • De Bono, J.S.1    Scher, H.I.2    Montgomery, R.B.3    Parker, C.4    Miller, M.C.5    Tissing, H.6
  • 90
    • 79961116885 scopus 로고    scopus 로고
    • Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: Systematic review and meta-analysis
    • Msaouel P, Koutsilieris M. Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis. BMC Cancer. 2011;11(1):336.
    • (2011) BMC Cancer. , vol.11 , Issue.1 , pp. 336
    • Msaouel, P.1    Koutsilieris, M.2
  • 93
    • 77955887652 scopus 로고    scopus 로고
    • Prognostic significance of survivin-expressing circulating tumour cells in T1G3 bladder cancer
    • Gradilone A, Petracca A, Nicolazzo C, Gianni W, Cortesi E, Naso G, et al. Prognostic significance of survivin-expressing circulating tumour cells in T1G3 bladder cancer. BJU Int. 2010;106 (5):710-5.
    • (2010) BJU Int. , vol.106 , Issue.5 , pp. 710-715
    • Gradilone, A.1    Petracca, A.2    Nicolazzo, C.3    Gianni, W.4    Cortesi, E.5    Naso, G.6
  • 94
    • 79952988035 scopus 로고    scopus 로고
    • The presence of circulating tumor cells does not predict extravesical disease in bladder cancer patients prior to radical cystectomy
    • Guzzo TJ, McNeil BK, Bivalacqua TJ, Elliott DJ, Sokoll LJ, Schoenberg MP. The presence of circulating tumor cells does not predict extravesical disease in bladder cancer patients prior to radical cystectomy. Urol Oncol. 2009.
    • (2009) Urol Oncol.
    • Guzzo, T.J.1    McNeil, B.K.2    Bivalacqua, T.J.3    Elliott, D.J.4    Sokoll, L.J.5    Schoenberg, M.P.6
  • 95
    • 79955438082 scopus 로고    scopus 로고
    • Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer
    • • Rink M, Chun FK, Minner S, Friedrich M, Mauermann O, Heinzer H et al. Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer. BJU Int. 2011;107(10):1668-75. This is the first study demonstrating an association of immunomagnetically captured CTC in the peripheral blood of patients with nonmetastatic UCB and worse cancer-specific outcomes.
    • (2011) BJU Int. , vol.107 , Issue.10 , pp. 1668-1675
    • Rink, M.1    Chun, F.K.2    Minner, S.3    Friedrich, M.4    Mauermann, O.5    Heinzer, H.6
  • 96
    • 33749053635 scopus 로고    scopus 로고
    • Molecular biology of bladder cancer: Prognostic and clinical implications
    • Mitra AP, Lin H, Datar RH, Cote RJ. Molecular biology of bladder cancer: prognostic and clinical implications. Clin Genitourin Cancer. 2006;5(1):67-77.
    • (2006) Clin Genitourin Cancer. , vol.5 , Issue.1 , pp. 67-77
    • Mitra, A.P.1    Lin, H.2    Datar, R.H.3    Cote, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.