Resveratrol downregulates acute pulmonary thromboembolism-induced pulmonary artery hypertension via p38 mitogen-activated protein kinase and monocyte chemoattractant protein-1 signaling in rats

Life Sciences

Volumn 90, Issue 19-20, 2012, Pages 721-727

  Chen, Chun ^a   Wang, Yang ^a   Cai, Xueding ^a   Zhang, Qi ^a   Huang, Xiaoying ^a   Xu, Honglei ^a   Yu, Fangyou ^a   Chen, Chan ^a   Lu, Yuanyuan ^a   Zhang, Weixi ^a   Yao, Dan ^a   Zhang, Zhoucang ^a   Yang, Lehe ^a   Ding, Cheng ^a   Wang, Liangxing ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Acute pulmonary thromboembolism; Monocyte chemoattractant protein 1; Phosphorylated p38 mitogen activated protein kinase; Pulmonary artery hypertension; Resveratrol

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; C 1142; CHIMERIC ANTIBODY; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT; CONTROLLED STUDY; DOWN REGULATION; LUNG ARTERY PRESSURE; LUNG EMBOLISM; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CHEMOKINE CCL2; DOWN-REGULATION; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HYPERTENSION, PULMONARY; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PULMONARY EMBOLISM; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STILBENES;

ANIMALIA; RATTUS; RODENTIA;

EID: 84860760784     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.03.008     Document Type: Article

References (26)

1. B.B. Aggarwal, A. Bhardwaj, R.S. Aggarwal, N.P. Seeram, S. Shishodia, and Y. Takada Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies Anticancer Res 24 2004 2783 2840 (Pubitemid 39409568)
2. P.K. Chakraborty, S.B. Mustafi, and S. Raha Pro-survival effects of repetitive low-grade oxidative stress are inhibited by simultaneous exposure to resveratrol Pharmacol Res 58 2008 281 289
3. J.P. Cullen, D. Morrow, Y. Jin, B. Curley, A. Robinson, and J.V. Sitzmann Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion J Vasc Res 44 2007 75 84 (Pubitemid 46105695)
4. M.J. Eagleton, P.K. Henke, C.E. Luke, A.E. Hawley, A. Bedi, and B.S. Knipp Inflammation and intimal hyperplasia associated with experimental pulmonary embolism J Vasc Surg 36 2002 581 588
5. S.R. Green, K.H. Han, Y. Chen, F. Almazan, I.F. Charo, and Y.I. Miller The cc chemokine mcp-1 stimulates surface expression of cx3cr1 and enhances the adhesion of monocytes to fractalkine/cx3cl1 via p38 mapk J Immunol 176 2006 7412 7420 (Pubitemid 43849043)
6. P. Gresele, P. Pignatelli, G. Guglielmini, R. Carnevale, A.M. Mezzasoma, and A. Ghiselli Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production J Nutr 138 2008 1602 1608
7. R.M. Grumbles, G.T.B. Casella, M.J. Rudinsky, S. Godfrey, P.M. Wood, and C.K. Thomas The immunophilin ligand fk506, but not the p38 kinase inhibitor sb203580, improves function of adult rat muscle reinnervated from transplants of embryonic neurons Neuroscience 130 2005 619 630 (Pubitemid 39601435)
8. M.S. Jang, E.N. Cai, G.O. Udeani, K.V. Slowing, C.F. Thomas, and C.W.W. Beecher Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 275 1997 218 220 (Pubitemid 127696281)
9. H. Kimura, O. Okada, N. Tanabe, Y. Tanaka, M. Terai, and Y. Takiguchi Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary artery hypertension Am J Respir Crit Care Med 164 2001 319 324 (Pubitemid 34001302)
10. F. Langer, R. Schramm, M. Bauer, D. Tscholl, T. Kunihara, and H.J. Schafers Cytokine response to pulmonary thromboendarterectomy Chest 126 2004 135 141 (Pubitemid 38943129)
11. J.C. Lee, S. Kumar, D.E. Griswold, D.C. Underwood, B.J. Votta, and J.L. Adams Inhibition of p38 map kinase as a therapeutic strategy Immunopharmacology 47 2000 185 201 (Pubitemid 30394538)
12. R.D. Loberg, C. Ying, M. Craig, L. Yan, L.A. Snyder, and K.J. Pienta Ccl2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration Neoplasia 9 2007 556 562 (Pubitemid 47121829)
13. D.W. Park, K. Baek, J.R. Kim, J.J. Lee, S.H. Ryu, and B.R. Chin Resveratrol inhibits foam cell formation via nadph oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1 Exp Mol Med 41 2009 171 179
14. J.E. Rectenwald, K.B. Deatrick, P. Sukheepod, E.M. Lynch, A.J. Moore, and D.M. Moaveni Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin J Vasc Surg 43 2006 800 808
15. C. Rius, M. Abu-Taha, C. Hermenegildo, L. Piqueras, J.M. Cerda-Nicolas, and A.C. Issekutz Trans- but not cis-resveratrol impairs angiotensin-ii-mediated vascular inflammation through inhibition of nf-kappa b activation and peroxisome proliferator-activated receptor-gamma upregulation J Immunol 185 2010 3718 3727
16. M.S. Runyon, M.A. Gellar, N. Sanapareddy, J.A. Kline, and J.A. Watts Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats Thromb J 8 2010 3
17. G. Sener, N. Topaloglu, A.O. Sehirli, F. Ercan, and N. Gedik Resveratrol alleviates bleomycin-induced lung injury in rats Pulm Pharmacol Ther 20 2007 642 649 (Pubitemid 47446339)
18. H. Shimada, and L.E. Rajagopalan Rho-kinase mediates lysophosphatidic acid-induced il-8 and mcp-1 production via p38 and jnk pathways in human endothelial cells FEBS Lett 584 2010 2827 2832
19. H. Shui, P. Gao, X.Y. Si, and G.H. Ding Mycophenolic acid inhibits albumin-induced mcp-1 expression in renal tubular epithelial cells through the p38 mapk pathway Mol Biol Rep 37 2010 1749 1754
20. Y.M. Smulders Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction Cardiovasc Res 48 2000 23 33
21. D.C. Souza-Costa, L. Figueiredo-Lopes, J.C. Alves, M.C. Semprini, R.F. Gerlach, and F.Q. Cunha Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9 Crit Care Med 35 2007 239 245 (Pubitemid 46035701)
22. R.M. Strieter, S.L. Kunkel, M.P. Keane, and T.J. Standiford Chemokines in lung injury - Thomas A. Neff lecture Chest 116 1999 103 110
23. S. Ulrich, S.M. Loitsch, O. Rau, A. von Knethen, B. Brune, and M. Schubert-Zsilavecz Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism Cancer Res 66 2006 7348 7354 (Pubitemid 44197718)
24. C.A. Wagenvoort Pathology of pulmonary thromboembolism Chest 107 1995 10 17
25. J.A. Watts, J. Zagorski, M.A. Gellar, B.G. Stevinson, and J.A. Kline Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats J Mol Cell Cardiol 41 2006 296 307 (Pubitemid 44080220)
26. J. Zhu, W. Yong, X.H. Wu, Y. Yu, J.H. Lv, and C.P. Liu Anti-inflammatory effect of resveratrol on tnf-alpha-induced mcp-1 expression in adipocytes Biochem Biophys Res Commun 369 2008 471 477