Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use

Journal of Nanobiotechnology

Volumn 8, Issue , 2010, Pages

  Prasad, Babu R ^a   Nikolskaya, Natalia ^a   Connolly, David ^a   Smith, Terry J ^a   Byrne, Stephen J ^b   Gérard, Valérie A ^b   Gun'ko, Yurii K ^b   Rochev, Yury ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE EFFECT; BIOLOGICAL ENTITIES; CDTE; CDTE QUANTUM DOTS; CELL BEHAVIOURS; CELL MORPHOLOGY; CELL RESPONSE; CELL STRESS; CELL VIABILITY; CELLULAR ACTIVITIES; CELLULAR INTERACTION; CONCENTRATION RANGES; CYTOTOXIC; DELETERIOUS EFFECTS; DNA QUANTIFICATION; GELATINE COATINGS; INCUBATION TIME; INDIVIDUAL CELLS; LONG TERM EXPOSURE; NEGATIVE IMPACTS; PC12 CELLS; PHEOCHROMOCYTOMA; PHOTONIC PROPERTIES; SURFACE ENVIRONMENTS; THERAPEUTIC TOOLS; THIOGLYCOLIC ACID;

CADMIUM ALLOYS; CADMIUM COMPOUNDS; CELL PROLIFERATION; CELLS; CONFOCAL MICROSCOPY; CYTOLOGY; GELS; INVESTMENTS; TOXIC MATERIALS;

SEMICONDUCTOR QUANTUM DOTS;

CADMIUM; QUANTUM DOT; TELLURIUM; THIOGLYCOLIC ACID;

ANIMAL CELL; ARTICLE; ATOM; CAPPING PHENOMENON; CELL ACTIVITY; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL LINE; CELL PROLIFERATION; CELL STRAIN; CELL STRESS; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CYTOPLASM; CYTOTOXICITY; DEATH; DNA DETERMINATION; ENVIRONMENT; GEL; IMAGING; INCUBATION TIME; LONG TERM EXPOSURE; NONHUMAN; PHEOCHROMOCYTOMA; RAT; SURFACE PROPERTY;

EID: 79952755184     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-8-7     Document Type: Article

References (58)

1. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles. Science 2002, 298:1759-1762. 10.1126/science.1077194, 12459582.
2. Gao X, Cui Y, Levenson RM, Chung LWK, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotech 2004, 22:969-976.
3. Goldman ER, Balighian ED, Mattoussi H, Kuno MK, Mauro JM, Tran PT, Anderson GP. Avidin: A Natural Bridge for Quantum Dot-Antibody Conjugates. J Am Chem Soc 2002, 124:6378-6382. 10.1021/ja0125570, 12033868.
4. Jaiswal JK, Goldman ER, Mattoussi H, Simon SM. Use of quantum dots for live cell imaging. Nat Methods 2004, 1:73-78. 10.1038/nmeth1004-73, 16138413.
5. Pinaud F, King D, Moore HP, Weiss S. Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides. J Am Chem Soc 2004, 126:6115-6123. 10.1021/ja031691c, 15137777.
6. Rosenthal SJ, Tomlinson I, Adkins EM, Schroeter S, Adams S, Swafford L, McBride J, Wang Y, DeFelice LJ, Blakely RD. Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals. J Am Chem Soc 2002, 124:4586-4594. 10.1021/ja003486s, 11971705.
7. Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotech 2003, 21:41-46.
8. Chen F, Gerion D. Fluorescent CdSe/ZnS Nanocrystal-Peptide Conjugates for Long-term, Nontoxic Imaging and Nuclear Targeting in Living Cells. Nano Lett 2004, 4:1827-1832.
9. Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP. Semiconductor Nanocrystals as Fluorescent Biological Labels. Science 1998, 281:2013-2016. 10.1126/science.281.5385.2013, 9748157.
10. Chan WC, Nie S. Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection. Science 1998, 281:2016-2018. 10.1126/science.281.5385.2016, 9748158.
11. Alivisatos AP. The use of nanocrystals in biological detection. Nat Biotech 2004, 22:47-52.
12. Han MY, Gao XH, Su JZ, Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotech 2001, 19:631-635.
13. Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW. Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo. Science 2003, 300:1434-1436. 10.1126/science.1083780, 12775841.
14. Chan WCW, Maxwell DJ, Gao X, Bailey RE, Han M, Nie S. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Op Biotech 2002, 13:40-46.
15. Vanmaekelbergh D, Liljeroth P. Electron-conducting quantum dot solids: novel materials based on colloidal semiconductor nanocrystals. Chem Soc Rev 2005, 34:299-312. 10.1039/b314945p, 15778764.
16. Pathak S, Cao E, Davidson MC, Jin SH, Silva GA. Quantum dot applications to neuroscience: New tools for probing neurons and glia. Journal of Neuroscience 2006, 26:1893-1895. 10.1523/JNEUROSCI.3847-05.2006, 16481420.
17. Yu WW, Qu LH, Guo WZ, Peng XG. Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals. Chem Mater 2003, 15:2854-2860.
18. Osaki F, Kanamori T, Sando S, Sera T, Aoyama Y. A Quantum Dot Conjugated Sugar Ball and Its Cellular Uptake. On the Size Effects of Endocytosis in the Subviral Region. JACS 2004, 126:6520-6521.
19. Gomez N, Winter JO, Shieh F, Saunders AE, Korgel BA, Schmidt CE. Challenges in quantum dot-neuron active interfacing. Talanta 2005, 67:462-471. 10.1016/j.talanta.2005.06.041, 18970190.
20. Jan E, Byrne SJ, Cuddihy M, Davies AM, Volkov Y, Gun'ko YK, Kotov NA. High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles. ACS Nano 2008, 2:928-938. 10.1021/nn7004393, 19206490.
21. Rajan SS, Liu HY, Vu TQ. Ligand-Bound Quantum Dot Probes for Studying the Molecular Scale Dynamics of Receptor Endocytic Trafficking in Live Cells. ACS Nano 2008, 2:1153-1166. 10.1021/nn700399e, 19206333.
22. Cui BX, Wu CB, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. PNAS 2007, 104:13666-13671. 10.1073/pnas.0706192104, 1959439, 17698956.
23. Tang ML, Xing TR, Zeng J, Wang HL, Li CC, Yin ST, Yan D, Deng HM, Liu J, Wang M, et al. Unmodified CdSe quantum dots induce elevation of cytoplasmic calcium levels and impairment of functional properties of sodium channels in rat primary cultured hippocampal neurons. Environmental Health Perspectives 2008, 116:915-922. 10.1289/ehp.11225, 2453160, 18629314.
24. Tang ML, Wang M, Xing TR, Zeng J, Wang HL, Ruan DY. Mechanisms of unmodified CdSe quantum dot-induced elevation of cytoplasmic calcium levels in primary cultures of rat hippocampal neurons. Biomater 2008, 29:4383-4391.
25. Lopez E, Figueroa S, Oset-Gasque MJ, Gonzalez MP. Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br J Pharmacol 2003, 138:901-911. 10.1038/sj.bjp.0705111, 1573722, 12642392.
26. Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA. Peptide-Conjugated Quantum Dots Activate Neuronal Receptors and Initiate Downstream Signaling of Neurite Growth. Nano Lett 2005, 5:603-607. 10.1021/nl047977c, 15826094.
27. Fan H, Leve EW, Scullin C, Gabaldon J, Tallant D, Bunge S, Boyle T, Wilson MC, Brinker CJ. Surfactant-Assisted Synthesis of Water-Soluble and Biocompatible Semiconductor Quantum Dot Micelles. Nano Letters 2005, 5:645-648. 10.1021/nl050017l, 15826102.
28. Mamedova NN, Kotov NA, Rogach AL, Studer J. Albumin-CdTe nanoparticle bioconjugates: Preparation, structure, and interunit energy transfer with antenna effect. Nano Lett 2001, 1:281-286.
29. Howarth M, Takao K, Hayashi Y, Ting AY. Targeting quantum dots to surface proteins in living cells with biotin ligase. PNAS 2005, 102:7583-7588. 10.1073/pnas.0503125102, 1129026,1129026, 15897449.
30. Sundara Rajan S, Vu TQ. Quantum Dots Monitor TrkA Receptor Dynamics in the Interior of Neural PC12 Cells. Nano Letters 2006, 6:2049-2059. 10.1021/nl0612650, 16968024.
31. Courty S, Luccardini C, Bellaiche Y, Cappello G, Dahan M. Tracking Individual Kinesin Motors in Living Cells Using Single Quantum-Dot Imaging. Nano Letters 2006, 6:1491-1495. 10.1021/nl060921t, 16834436.
32. Nan X, Sims PA, Chen P, Xie XS. Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots. P Phys Chem B 2006, 109:24220-24224.
33. Kondoh M, Araragi S, Sato K, Higashimoto M, Takiguchi M, Sato M. Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicol 2002, 170:111-117.
34. Limaye DA, Shaikh ZA. Cytotoxicity of Cadmium and Characteristics of Its Transport in Cardiomyocytes. Toxicol Appl Pharmacol 1999, 154:59-66. 10.1006/taap.1998.8575, 9882592.
35. Rikans LE, Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem Molec Tox 2000, 14:110-117.
36. Nel A, Xia T, Madler L, Li N. Toxic Potential of Materials at the Nanolevel. Science 2006, 311:622-627. 10.1126/science.1114397, 16456071.
37. Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, Yasuhara M, Suzuki K, Yamamoto K. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 2004, 4:2163-2169.
38. Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004, 4:11-18.
39. Guo G, Liu W, Liang J, He Z, Xu H, Yang X. Probing the cytotoxicity of CdSe quantum dots with surface modification. Mater Lett 2007, 61:1641-1644.
40. Lovrić J, Cho SJ, Winnik FM, Maysinger D. Unmodified Cadmium Telluride Quantum Dots Induce Reactive Oxygen Species Formation Leading to Multiple Organelle Damage and Cell Death. Chem Biol 2005, 12:1227-1234. 10.1016/j.chembiol.2005.09.008, 16298302.
41. Kirchner C, Liedl T, Kudera S, Pellegrino T, MunozJavier A, Gaub HE, Stolzle S, Fertig N, Parak WJ. Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles. Nano Lett 2005, 5:331-338. 10.1021/nl047996m, 15794621.
42. Chang E, Thekkek N, Yu WW, Colvin VL, Drezek R. Evaluation of Quantum Dot Cytotoxicity Based on Intracellular Uptake. Small 2006, 2:1412-1417. 10.1002/smll.200600218, 17192996.
43. Wang L, Nagesha D, Selvarasah S, Dokmeci M, Carrier R. Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures. J Nanobiotech 2008, 6:11.
44. Byrne SJ, Williams Y, Davies A, Corr SA, Rakovich A, Gun'ko YK, Rakovich YP, Donegan JF, Volkov Y. "Jelly Dots": Synthesis and Cytotoxicity Studies of CdTe Quantum Dot-Gelatin Nanocomposites. Small 2007, 3:1152-1156. 10.1002/smll.200700090, 17534993.
45. Lovrić J, Bazzi HS, Cuie Y, Fortin GRA, Winnik FM, Maysinger D. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 2005, 83:377-385. 10.1007/s00109-004-0629-x, 15688234.
46. Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K. Microbiology and Immunology 2004, 48:669-675.
47. Cho SJ, Maysinger D, Jain M, Roder B, Hackbarth S, Winnik FM. Long-Term Exposure to CdTe Quantum Dots Causes Functional Impairments in Live Cells. Langmuir 2007, 23:1974-1980. 10.1021/la060093j, 17279683.
48. Tan WB, Huang N, Zhang Y. Ultrafine biocompatible chitosan nanoparticles encapsulating multi-coloured quantum dots for bioapplications. J Colloid and Interface Sci 2007, 310:464-470.
49. Byrne SJ, Corr SA, Rakovich TY, Gun'ko YK, Rakovich YP, Donegan JF, Mitchell S, Volkov Y. Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging. J Mat Chem 2006, 16:2896-2902.
50. Tang Z, Ozturk B, Wang Y, Kotov NA. Simple Preparation Strategy and One-Dimensional Energy Transfer in CdTe Nanoparticle Chains. J Phys Chem B 2004, 108:6927-6931.
51. Conroy JBSJ, Gun'ko YK, Rakovich YP, Donegan JF, Davies A, Kelleher D, Volkov Y. CdTe Nanoparticles Display Tropism to Core Histones and Histone-Rich Cell Organelles. Small 2008, 4:2006-2015. 10.1002/smll.200800088, 18949793.
52. Monteiro-Riviere NA, Inman AO, Zhang LW. Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line. Toxicol Appl Pharmacol 2009, 234:222-235. 10.1016/j.taap.2008.09.030, 18983864.
53. Nabiev I, Mitchell S, Davies A, Williams Y, Kelleher D, Moore R, Gun'ko YK, Byrne S, Rakovich YP, Donegan JF, et al. Nonfunctionalized Nanocrystals Can Exploit a Cell's Active Transport Machinery Delivering Them to Specific Nuclear and Cytoplasmic Compartments. Nano Letters 2007, 7:3452-3461. 10.1021/nl0719832, 17949046.
54. Chan W-H, Shiao N-H, Lu P-Z. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol Lett 2006, 167:191-200. 10.1016/j.toxlet.2006.09.007, 17049762.
55. Lee H-M, Shin D-M, Song H-M, Yuka J-M, Lee Z-W, Lee S-H, Hwang SM, Kim J-M, Lee C-S, Jo E-K. Nanoparticles up-regulate tumor necrosis factor-α and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation. Toxicol Appl Pharm 2009, 238:160-169.
56. Wan RMY, Zhang X, Chien S, Tollerud DJ, Zhang Q. Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation. Toxicol Appl Pharm 2008, 233:276-285.
57. Calabrese EJ, Baldwin LA. Applications of hormesis in toxicology, risk assessment and chemotherapeutics. Trends Pharmacol Sci 2002, 23:331-337. 10.1016/S0165-6147(02)02034-5, 12119154.
58. Gaponik N, Talapin DV, Rogach AL, Hoppe K, Shevchenko EV, Kornowski A, Eychmüller A, Weller H. Thiol-capping of CdTe nanocrystals: An alternative to organometallic synthetic routes. J Phys Chem B 2002, 106:7177-7185.