Pretreatment with pentoxifylline and N-acetylcysteine in liver ischemia reperfusion-induced renal injury

Renal Failure

Volumn 34, Issue 5, 2012, Pages 610-615

  Seifi, Behjat ^a   Kadkhodaee, Mehri ^a   Delavari, Fatemeh ^a   Mikaeili, Saideh ^a   Shams, Sedigheh ^a   Ostad, Seyed Naser ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ischemia reperfusion injury; Kidney; Liver; N acetylcysteine; Oxidative stress; Pentoxifylline

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GLUTATHIONE; MALONALDEHYDE; PENTOXIFYLLINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL STRUCTURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; HEPATIC ARTERY; KIDNEY INJURY; KIDNEY PARENCHYMA; LIVER FUNCTION; LIVER INJURY; LIVER ISCHEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PORTAL VEIN; PRIORITY JOURNAL; RAT; REPERFUSION; REPERFUSION INJURY; UREA NITROGEN BLOOD LEVEL;

ACETYLCYSTEINE; ACUTE KIDNEY INJURY; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FREE RADICAL SCAVENGERS; LIVER; MALE; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 84860758878     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2012.660827     Document Type: Article

References (37)

1. Tanaka Y, Maher JM, Chen C, Klaassen CD. Hepatic ischemiareperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol. 2007;71(3):817-825. (Pubitemid 46294093)
2. Davis CL, Gonwa TA, Wilkinson AH. Pathophysiology of renal disease associated with liver disorders: Implications for liver transplantation. Part I. Liver Transpl. 2002;8(2):91-109. (Pubitemid 34202136)
3. Miranda LE, Capellini VK, Reis GS, Celotto AC, Carlotti Jr. CG, Evora PR. Effects of partial liver ischemia followed by global liver reperfusion on the remote tissue expression of nitric oxide synthase: Lungs and kidneys. Transplant Proc. 2010;42(5):1557-1562.
4. Okaya T, Lentsch AB. Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion. J Invest Surg. 2003;16(3):141-147. (Pubitemid 36926518)
5. Weinbroum AA, Hochhauser E, Rudick V, et al. Direct induction of acute lung and myocardial dysfunction by liver ischemia and reperfusion. J Trauma. 1997;43(4):627-633; discussion 33-35.
6. Hochhauser E, Ben-Ari Z, Pappo O, Chepurko Y, Vidne BA. TPEN attenuates hepatic apoptotic ischemia/ reperfusion injury and remote early cardiac dysfunction. Apoptosis. 2005;10(1):53-62. (Pubitemid 40558114)
7. Park SW, Kim M, Chen SW, D'Agati VD, Lee HT. Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. Shock. 2010;33(1):31-42.
8. Okumura AS, Rodrigues LE, Martinelli R. Pentoxifylline in ischemia-induced acute kidney injury in rats. Ren Fail. 2009;31(9):829-832.
9. Lin SL, Chen YM, Chiang WC, Wu KD, Tsai TJ. Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: A 12-month randomized trial. Am J Kidney Dis. 2008;52(3):464-474.
10. Nitescu N, Ricksten SE, Marcussen N, et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischemiareperfusion. Nephrol Dial Transplant. 2006;21(5):1240-1247.
11. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 1990;186:407-421. (Pubitemid 20279982)
12. Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem. 1980;106(1):207-212. (Pubitemid 11246585)
13. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem. 1969;27(3):502-522.
14. Colletti LM, Burtch GD, Remick DG, et al. The production of tumor necrosis factor alpha and the development of a pulmonary capillary injury following hepatic ischemia/reperfusion. Transplantation. 1990;49(2):268-272. (Pubitemid 20088158)
15. Behrends M, Hirose R, Park YH, et al. Remote renal injury following partial hepatic ischemia/reperfusion injury in rats. J Gastrointest Surg. 2008;12(3):490-495.
16. Lu X, Hamilton JA, Shen J, et al. Role of tumor necrosis factoralpha in myocardial dysfunction and apoptosis during hindlimb ischemia and reperfusion. Crit Care Med. 2006;34(2):484-491. (Pubitemid 43145630)
17. Souza DG, Cassali GD, Poole S, Teixeira MM. Effects of inhibition of PDE4 and TNF-alpha on local and remote injuries following ischemia and reperfusion injury. Br J Pharmacol. 2001;134(5):985-994. (Pubitemid 33052157)
18. Wan L, Bellomo R, Di Giantomasso D, Ronco C. The pathogenesis of septic acute renal failure. Curr Opin Crit Care. 2003;9(6):496-502. (Pubitemid 37518649)
19. Kaynar K, Gul S, Ersoz S, Ozdemir F, Ulusoy H, Ulusoy S. Amikacin-induced nephropathy: Is there any protective way? Ren Fail. 2007;29(1):23-27.
20. Di Giorno C, Pinheiro HS, Heinke T, et al. Beneficial effect of N-acetyl-cysteine on renal injury triggered by ischemia and reperfusion. Transplant Proc. 2006;38(9):2774-2776. (Pubitemid 44737976)
21. Kizilgun M, Poyrazoglu Y, Oztas Y, et al. Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. Ren Fail. 2011;33(5):512-517.
22. Hamidian Jahromi A, Kessaris N, Sharifian M, Roozbeh J. Protective effect of pentoxifylline in the kidney perfusion fluid on the transplanted kidney. Saudi J Kidney Dis Transpl. 2009;20(2):290-291.
23. Moussavian MR, Scheuer C, SchmidtM, et al. Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury. Langenbecks Arch Surg. 2011;396(2):231-241.
24. Nagasaki H, Nakano H, Boudjema K, et al. Efficacy of preconditioning with N-acetylcysteine against reperfusion injury after prolonged cold ischemia in rats liver in which glutathione had been reduced by buthionine sulphoximine. Eur J Surg. 1998;164(2):139-146. (Pubitemid 28092789)
25. Cerqueira NF, Hussni CA, Yoshida WB, Sequeira JL, Padovani CR. Effects of pentoxifylline and N-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats. Int Angiol. 2008;27(6):512-521.
26. Coe DA, Freischlag JA, Johnson D, et al. Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. J Surg Res. 1997;67(1):21-25. (Pubitemid 27185016)
27. Steeb GD, Wilson MA, Garrison RN. Pentoxifylline preserves small-intestine microvascular blood flow during bacteremia. Surgery. 1992;112(4):756-763; discussion 63-64.
28. Tireli GA, Salman T, Ozbey H, Abbasoglu L, Toker G, Celik A. The effect of pentoxifylline on intestinal anastomotic healing after ischemia. Pediatr Surg Int. 2003;19(1-2):88-90. (Pubitemid 36717309)
29. Koksal C, Bozkurt AK, Cangel U, et al. Attenuation of ischemia/ reperfusion injury by N-acetylcysteine in a rat hind limb model. J Surg Res. 2003;111(2):236-239. (Pubitemid 36808915)
30. Portella AO, Montero EF, Poli de Figueiredo LF, Bueno AS, Thurow AA, Rodrigues FG. Effects of N-acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock. Transplant proc. 2004;36(4):846-848. (Pubitemid 38766196)
31. Toda K, Kumagai N, Kaneko F, et al. Pentoxifylline prevents pig serum-induced rat liver fibrosis by inhibiting interleukin-6 production. J Gastroenterol Hepatol. 2009;24(5):860-865.
32. Oksuz H, Bulbuloglu E, Senoglu N, et al. Re-protective effects of pre- and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the kidney. Ren Fail. 2009;31(4):297-302.
33. Savas S, Delibas N, Savas C, Sutcu R, Cindas A. Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. Spinal Cord. 2002;40(5):224-229. (Pubitemid 34499303)
34. Zaitone S, Hassan N, El-Orabi N, El-Awady el S. Pentoxifylline and melatonin in combination with pioglitazone ameliorate experimental non-alcoholic fatty liver disease. Eur J Pharmacol. 2011;662(1-3):70-77.
35. Da Silveira M, Yoshida WB. Trimetazidine and Nacetylcysteine in attenuating hind-limb ischemia and reperfusion injuries: Experimental study in rats. Int Angiol. 2009;28(5): 412-417.
36. Shimizu MH, Danilovic A, Andrade L, et al. N-acetylcysteine protects against renal injury following bilateral ureteral obstruction. Nephrol Dial Transplant. 2008;23(10):3067-3073.
37. Kim YK, Yoo JH, Woo JS, Jung JS, Kim BS, Kim SY. Effect of pentoxifylline on ischemic acute renal failure in rabbits. Ren Fail. 2001;23(6):757-772. (Pubitemid 34014191)