99mTc-labeled RGD-BBN peptide for small-animal SPECT/CT of lung carcinoma

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1409-1417

  Liu, Zhaofei ^a,b   Huang, Jinming ^a,b   Dong, Chengyan ^a,b   Cui, Liyang ^a,b   Jin, Xiaona ^c   Jia, Bing ^a,b   Zhu, Zhaohui ^c   Li, Fang ^c   Wang, Fan ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

GRPR; integrin v 3; lung carcinoma; RGD bombesin; single photon emission computed tomography (SPECT)

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BOMBESIN; FLUORODEOXYGLUCOSE F 18; GASTRIN RELEASING PEPTIDE RECEPTOR; TECHNETIUM 99M; TRIPHENYLPHOSPHINE; TRISODIUM TRIPHENYLPHOSPHINE 3,3',3'' TRISULFONATE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; ARGINYL-GLYCYL-ASPARTIC ACID; DIAGNOSTIC AGENT; OLIGOPEPTIDE; PEPTIDE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX;

ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; LEWIS CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT; ANIMAL; C57BL MOUSE; CARCINOMA; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; LUNG TUMOR; MALE; METHODOLOGY; TUMOR CELL LINE;

ANIMALS; BOMBESIN; CARCINOMA; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES; ORGANOTECHNETIUM COMPOUNDS; PEPTIDES; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84860732729     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200661t     Document Type: Article

References (31)

1. Jemal, A.; Siegel, R.; Xu, J.; Ward, E. Cancer statistics, 2010 CA Cancer J. Clin. 2010, 60 (5) 277-300
2. Beadsmoore, C. J.; Screaton, N. J. Classification, staging and prognosis of lung cancer Eur. J. Radiol. 2003, 45 (1) 8-17
3. Li, X.; Zhang, H.; Xing, L.; Ma, H.; Xie, P.; Zhang, L.; Xu, X.; Yue, J.; Sun, X.; Hu, X.; Chen, M.; Xu, W.; Chen, L.; Yu, J. Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study Radiother. Oncol. 2012, 102 (2) 246-250
4. Ibeas, P.; Cantos, B.; Gasent, J. M.; Rodriguez, B.; Provencio, M. PET-CT in the staging and treatment of non-small-cell lung cancer Clin. Transl. Oncol. 2011, 13 (6) 368-77
5. Demura, Y.; Tsuchida, T.; Ishizaki, T.; Mizuno, S.; Totani, Y.; Ameshima, S.; Miyamori, I.; Sasaki, M.; Yonekura, Y. 18F-FDG accumulation with PET for differentiation between benign and malignant lesions in the thorax J. Nucl. Med. 2003, 44 (4) 540-8
6. Halter, G.; Storck, M.; Guhlmann, A.; Frank, J.; Grosse, S.; Liewald, F. FDG positron emission tomography in the diagnosis of peripheral pulmonary focal lesions Thorac Cardiovasc. Surg. 2000, 48 (2) 97-101
7. Shreve, P. D.; Anzai, Y.; Wahl, R. L., Pitfalls in oncologic diagnosis with FDG PET imaging: physiologic and benign variants. Radiographics 1999, 19, (1), 61-77; quiz 150-1.
8. Strauss, L. G. Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients Eur. J. Nucl. Med. 1996, 23 (10) 1409-15
9. Lee, S.; Xie, J.; Chen, X. Peptide-based probes for targeted molecular imaging Biochemistry 2010, 49 (7) 1364-76
10. Nanda, P. K.; Lane, S. R.; Retzloff, L. B.; Pandey, U. S.; Smith, C. J. Radiolabeled regulatory peptides for imaging and therapy Curr. Opin. Endocrinol. Diabetes Obes. 2010, 17 (1) 69-76
11. Liu, Z.; Wang, F. Dual-targeted molecular probes for cancer imaging Curr. Pharm. Biotechnol. 2010, 11 (6) 610-9
12. Liu, Z.; Yan, Y.; Chin, F. T.; Wang, F.; Chen, X. Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN J. Med. Chem. 2009, 52 (2) 425-32
13. Liu, Z.; Li, Z. B.; Cao, Q.; Liu, S.; Wang, F.; Chen, X. Small-animal PET of tumors with 64Cu-labeled RGD-bombesin heterodimer J. Nucl. Med. 2009, 50 (7) 1168-77
14. Zhao, H.; Liu, Y.; Jia, B.; Wang, F.; Liu, Z. MicroPET imaging of breast cancer with a dual-targeted molecular probe 68Ga-RGD-BBN Acta Biophys. Sin. 2011, 27 (4) 335-344
15. Cuttitta, F.; Carney, D. N.; Mulshine, J.; Moody, T. W.; Fedorko, J.; Fischler, A.; Minna, J. D. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer Nature 1985, 316 (6031) 823-6
16. Leyton, J.; Garcia-Marin, L. J.; Tapia, J. A.; Jensen, R. T.; Moody, T. W. Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells Cancer Lett. 2001, 162 (1) 87-95
17. Sridhar, S. S.; Shepherd, F. A. Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer Lung Cancer 2003, 42 (Suppl 1) S81-91
18. Desgrosellier, J. S.; Cheresh, D. A. Integrins in cancer: biological implications and therapeutic opportunities Nat. Rev. Cancer 2010, 10 (1) 9-22
19. 99mTc- labeled radiopharmaceuticals Bioconjugate Chem. 1999, 10 (5) 808-14
20. 3 Expressed on both Tumor Cells and Neovasculature Bioconjugate Chem. 2010, 21, 548-555
21. Tang, N.; Du, G.; Wang, N.; Liu, C.; Hang, H.; Liang, W. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin J. Natl. Cancer Inst. 2007, 99 (13) 1004-15
22. Liu, Z.; Niu, G.; Wang, F.; Chen, X. 68Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging Eur. J. Nucl. Med. Mol. Imaging 2009, 36 (9) 1483-94
23. 3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers Mol. Imaging 2010, 9 (1) 21-9
24. Yan, Y.; Chen, X. Peptide heterodimers for molecular imaging Amino Acids 2011, 41 (5) 1081-92
25. Nabi, H. A.; Zubeldia, J. M. Clinical applications of 18F-FDG in oncology. J. Nucl. Med. Technol. 2002, 30, (1), 3-9; quiz 10-1.
26. Autio, A.; Ujula, T.; Luoto, P.; Salomaki, S.; Jalkanen, S.; Roivainen, A. PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG Eur. J. Nucl. Med. Mol. Imaging 2010, 37 (10) 1918-25
27. Liu, R. S.; Chou, T. K.; Chang, C. H.; Wu, C. Y.; Chang, C. W.; Chang, T. J.; Wang, S. J.; Lin, W. J.; Wang, H. E. Biodistribution, pharmacokinetics and PET imaging of [(18)F]FMISO, [(18)F]FDG and [(18)F]FAc in a sarcoma- and inflammation-bearing mouse model Nucl. Med. Biol. 2009, 36 (3) 305-12
28. Chang, C. H.; Wang, H. E.; Wu, S. Y.; Fan, K. H.; Tsai, T. H.; Lee, T. W.; Chang, S. R.; Liu, R. S.; Chen, C. F.; Chen, C. H.; Fu, Y. K. Comparative evaluation of FET and FDG for differentiating lung carcinoma from inflammation in mice Anticancer Res. 2006, 26 (2A) 917-25
29. van Waarde, A.; Cobben, D. C.; Suurmeijer, A. J.; Maas, B.; Vaalburg, W.; de Vries, E. F.; Jager, P. L.; Hoekstra, H. J.; Elsinga, P. H. Selectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model J. Nucl. Med. 2004, 45 (4) 695-700
30. Uchida, K.; Kojima, A.; Morokawa, N.; Tanabe, O.; Anzai, C.; Kawakami, M.; Eto, Y.; Yoshimura, K. Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer J. Cancer Res. Clin. Oncol. 2002, 128 (12) 633-40
31. Siegfried, J. M.; Krishnamachary, N.; Gaither Davis, A.; Gubish, C.; Hunt, J. D.; Shriver, S. P. Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer Pulm. Pharmacol. Ther. 1999, 12 (5) 291-302