-
1
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
2
-
-
79959231780
-
Importance of molecular features of non-small cell lung cancer for choice of treatment
-
Moran C: Importance of molecular features of non-small cell lung cancer for choice of treatment. Am J Pathol 178: 1940-1948, 2011.
-
(2011)
Am J Pathol
, vol.178
, pp. 1940-1948
-
-
Moran, C.1
-
3
-
-
80052469772
-
Adjuvant therapy in non-small cell lung cancer: Future treatment prospects and paradigms
-
Carbone DP and Felip E: Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms. Clin Lung Cancer 12: 261-271, 2011.
-
(2011)
Clin Lung Cancer
, vol.12
, pp. 261-271
-
-
Carbone, D.P.1
Felip, E.2
-
4
-
-
80052671832
-
Vandetanib for the treatment of non-small cell lung cancer
-
Wong HL and de Boer RH: Vandetanib for the treatment of non-small cell lung cancer. Exp Opin Pharmacother 12: 2271-2278, 2011.
-
(2011)
Exp Opin Pharmacother
, vol.12
, pp. 2271-2278
-
-
Wong, H.L.1
De Boer, R.H.2
-
5
-
-
84857658325
-
Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC)
-
Belani CP, Goss G and Blumenschein G Jr: Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC). Cancer Treat Rev 37: 173-184, 2012.
-
(2012)
Cancer Treat Rev
, vol.37
, pp. 173-184
-
-
Belani, C.P.1
Goss, G.2
Blumenschein Jr., G.3
-
6
-
-
84860703790
-
124I-Labeled anti-HER2-specific C6.5 diabody
-
National Center for Biotechnology Information (US), Bethesda, MD
-
Leung K: 124I-Labeled anti-HER2-specific C6.5 diabody. In: Molecular Imaging and Contrast Agent Database (MICAD) (Internet). National Center for Biotechnology Information (US), Bethesda, MD; 2004-2011, 2011.
-
(2011)
Molecular Imaging and Contrast Agent Database (MICAD) (Internet)
, pp. 2004-2011
-
-
Leung, K.1
-
7
-
-
68949201629
-
Activating and resistance mutations of EGFR in non-small cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
-
Gazdar AF: Activating and resistance mutations of EGFR in non-small cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28: S24-S31, 2009.
-
(2009)
Oncogene
, vol.28
-
-
Gazdar, A.F.1
-
8
-
-
33846187218
-
Update on epidermal growth factor receptor mutations in non-small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-06-0658
-
Riely GJ, Politi KA, Miller VA and Pao W: Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 12: 7232-7241, 2006. (Pubitemid 46095394)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.24
, pp. 7232-7241
-
-
Riely, G.J.1
Politi, K.A.2
Miller, V.A.3
Pao, W.4
-
9
-
-
79960702788
-
Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS)
-
Fukuoka M, Wu Y, Thongprasert S, et al: Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS). J Clin Oncol 29: 2866-2874, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.2
Thongprasert, S.3
-
10
-
-
38049038935
-
A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
-
Eskens FA, Mom CH, Planting AS, et al: A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer 98: 80-85, 2008.
-
(2008)
Br J Cancer
, vol.98
, pp. 80-85
-
-
Eskens, F.A.1
Mom, C.H.2
Planting, A.S.3
-
11
-
-
33744824672
-
Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors
-
DOI 10.1200/JCO.2005.01.8960
-
Erlichman C, Hidalgo M, Boni JP, et al: Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J Clin Oncol 24: 2252-2260, 2006. (Pubitemid 46630654)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.15
, pp. 2252-2260
-
-
Erlichman, C.1
Hidalgo, M.2
Boni, J.P.3
Martins, P.4
Quinn, S.E.5
Zacharchuk, C.6
Amorusi, P.7
Adjei, A.A.8
Rowinsky, E.K.9
-
12
-
-
33746485766
-
Epidermal Growth Factor Receptor Targeting in Cancer
-
DOI 10.1053/j.seminoncol.2006.04.003, PII S0093775406001771
-
Mendelsohn J and Baselga J: Epidermal growth factor receptor targeting in cancer. Semin Oncol 33: 369-385, 2006. (Pubitemid 44142736)
-
(2006)
Seminars in Oncology
, vol.33
, Issue.4
, pp. 369-385
-
-
Mendelsohn, J.1
Baselga, J.2
-
13
-
-
79960035905
-
Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors
-
Zhao Q, Shentu J, Xu N, et al: Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors. Lung Cancer 73: 195-202, 2011.
-
(2011)
Lung Cancer
, vol.73
, pp. 195-202
-
-
Zhao, Q.1
Shentu, J.2
Xu, N.3
-
14
-
-
13844292729
-
Dynamic monitoring of cytotoxicity on microelectronic sensors
-
DOI 10.1021/tx049721s
-
Xing JZ, Zhu L, Jackson JA, et al: Dynamic monitoring of cytotoxicity on microelectronic sensors. Chem Res Toxicol 18: 154-161, 2005. (Pubitemid 40256233)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.2
, pp. 154-161
-
-
Xing, J.Z.1
Zhu, L.2
Jackson, J.A.3
Gabos, S.4
Sun, X.-J.5
Wang, X.-B.6
Xu, X.7
-
15
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139, 2004. (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
16
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez JG, Jänne PA, Lee JC, et al: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497-1500, 2004. (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
17
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
-
DOI 10.1073/pnas.0405220101
-
Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101: 13306-13311, 2004. (Pubitemid 39209661)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
Mardis, E.11
Kupfer, D.12
Wilson, R.13
Kris, M.14
Varmus, H.15
-
18
-
-
0034773992
-
The EGFR family and its ligands in human cancer signaling mechanisms and therapeutic opportunities
-
Yarden Y: The EGFR family and its ligands in human cancer signaling mechanisms and therapeutic opportunities. Eur J Cancer 37: S3-S8, 2001.
-
(2001)
Eur J Cancer
, vol.37
-
-
Yarden, Y.1
-
19
-
-
0345098554
-
The epidermal growth factor receptor pathway and its inhibition as anticancer therapy
-
DOI 10.1358/dot.2003.39.1.799432
-
Janmaat ML and Giaccone G: The epidermal growth factor receptor pathway and its inhibition as anticancer therapy. Drugs Today 39: 61-80, 2003. (Pubitemid 37509402)
-
(2003)
Drugs of Today
, vol.39
, Issue.SUPPL. C
, pp. 61-80
-
-
Janmaat, M.L.1
Giaccone, G.2
-
20
-
-
0037429737
-
Epidermal growth factor receptor: Mechanisms of activation and signalling
-
DOI 10.1016/S0014-4827(02)00098-8
-
Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW and Burgess AW: Epidermal growth factor receptor: mechanisms of activation and signaling. Exp Cell Res 284: 31-53, 2003. (Pubitemid 36331965)
-
(2003)
Experimental Cell Research
, vol.284
, Issue.1
, pp. 31-53
-
-
Jorissen, R.N.1
Walker, F.2
Pouliot, N.3
Garrett, T.P.J.4
Ward, C.W.5
Burgess, A.W.6
-
21
-
-
0037229076
-
Targeting the epidermal growth factor receptor in cancer: Apoptosis takes center stage
-
Kari C, Chan TO, Rocha de Quadros M and Rodeck U: Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer Res 63: 1-5, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 1-5
-
-
Kari, C.1
Chan, T.O.2
Rocha De Quadros, M.3
Rodeck, U.4
-
22
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361: 947-957, 2009.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
23
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al: Erlotinib in previously treated non-small cell lung cancer. N Engl J Med 353: 123-132, 2005. (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
24
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
-
Thatcher N, Chang A, Parikh P, et al: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366: 1527-1537, 2005. (Pubitemid 41540110)
-
(2005)
Lancet
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Pereira, J.R.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
25
-
-
79957492069
-
American Society of clinical oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy
-
Keedy VL, Temin S, Somerfield MR, et al: American Society of clinical oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J Clin Oncol 29: 2121-2127, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2121-2127
-
-
Keedy, V.L.1
Temin, S.2
Somerfield, M.R.3
-
26
-
-
23844544647
-
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinoma
-
Pan Q, Pao W and Ladanyi M: Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 7: 396-403, 2005. (Pubitemid 41149655)
-
(2005)
Journal of Molecular Diagnostics
, vol.7
, Issue.3
, pp. 396-403
-
-
Pan, Q.1
Pao, W.2
Ladanyi, M.3
-
27
-
-
32944481596
-
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
-
DOI 10.1158/1078-0432.CCR-05-1846
-
Riely GJ, Pao W, Pham D, et al: Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 12: 839-844, 2006. (Pubitemid 43259866)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.3 I
, pp. 839-844
-
-
Riely, G.J.1
Pao, W.2
Pham, D.3
Li, A.R.4
Rizvi, N.5
Venkatraman, E.S.6
Zakowski, M.F.7
Kris, M.G.8
Ladanyi, M.9
Miller, V.A.10
-
28
-
-
33646242760
-
Clinical experience with erlotinib in non-small cell lung cancer
-
Barc
-
Felip E and Rosell R: Clinical experience with erlotinib in non-small cell lung cancer. Drugs Today (Barc) 42: 147-156, 2006.
-
(2006)
Drugs Today
, vol.42
, pp. 147-156
-
-
Felip, E.1
Rosell, R.2
-
29
-
-
70349464846
-
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancers dependent on the epidermal growth factor receptor pathway
-
Nguyen KS, Kobayashi S and Costa DB: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 10: 281-289, 2009.
-
(2009)
Clin Lung Cancer
, vol.10
, pp. 281-289
-
-
Nguyen, K.S.1
Kobayashi, S.2
Costa, D.B.3
-
30
-
-
72949092456
-
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
-
Zhou W, Ercan D, Chen L, et al: Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462: 1070-1074, 2009.
-
(2009)
Nature
, vol.462
, pp. 1070-1074
-
-
Zhou, W.1
Ercan, D.2
Chen, L.3
-
31
-
-
33745628326
-
EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification
-
DOI 10.1111/j.1349-7006.2006.00233.x
-
Yokoyama T, Kondo M, Goto Y, et al: EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification. Cancer Sci 97: 753-759, 2006. (Pubitemid 43983788)
-
(2006)
Cancer Science
, vol.97
, Issue.8
, pp. 753-759
-
-
Yokoyama, T.1
Kondo, M.2
Goto, Y.3
Fukui, T.4
Yoshioka, H.5
Yokoi, K.6
Osada, H.7
Imaizumi, K.8
Hasegawa, Y.9
Shimokata, K.10
Sekido, Y.11
-
32
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
DOI 10.1073/pnas.0709662105
-
Yun CH, Mengwasser KE, Toms AV, et al: The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci USA 105: 2070-2075, 2008. (Pubitemid 351439466)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.6
, pp. 2070-2075
-
-
Yun, C.-H.1
Mengwasser, K.E.2
Toms, A.V.3
Woo, M.S.4
Greulich, H.5
Wong, K.-K.6
Meyerson, M.7
Eck, M.J.8
-
33
-
-
76249108622
-
Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation
-
Sos ML, Rode HB, Heynck S, et al: Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation. Cancer Res 70: 868-874, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 868-874
-
-
Sos, M.L.1
Rode, H.B.2
Heynck, S.3
-
34
-
-
79955592737
-
Suppression of Stat3 activity sensitizes gefitinib-resistant non-small cell lung cancer cells
-
Chiu HC, Chou DL, Huang CT, et al: Suppression of Stat3 activity sensitizes gefitinib-resistant non-small cell lung cancer cells. Biochem Pharmacol 81: 1263-1270, 2011.
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 1263-1270
-
-
Chiu, H.C.1
Chou, D.L.2
Huang, C.T.3
-
35
-
-
79952207890
-
KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib
-
Kurtze I, Sonnemann J and Beck JF: KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib. Oncol Rep 25: 1021-1029, 2011.
-
(2011)
Oncol Rep
, vol.25
, pp. 1021-1029
-
-
Kurtze, I.1
Sonnemann, J.2
Beck, J.F.3
-
36
-
-
84856771870
-
Cost-effect- tiveness of epidermal growth factor receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma of the lung
-
de Lima Lopes G Jr, Segel JE, Tan DS, Do YK, Mok T and Finkelstein EA: Cost-effect- tiveness of epidermal growth factor receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma of the lung. Cancer 118: 1032-1039, 2012.
-
(2012)
Cancer
, vol.118
, pp. 1032-1039
-
-
De Lima Lopes Jr., G.1
Segel, J.E.2
Tan, D.S.3
Do, Y.K.4
Mok, T.5
Finkelstein, E.A.6
-
38
-
-
29144435996
-
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
-
DOI 10.1042/BJ20050908
-
Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR and Kolch W: Computational modelling of the receptor-tyrosinekinase- activated MAPK pathway. Biochem J 392: 249-261, 2005. (Pubitemid 41796513)
-
(2005)
Biochemical Journal
, vol.392
, Issue.2
, pp. 249-261
-
-
Orton, R.J.1
Sturm, O.E.2
Vyshemirsky, V.3
Calder, M.4
Gilbert, D.R.5
Kolch, W.6
-
39
-
-
77953758752
-
Design of selective, ATP-competitive inhibitors of Akt
-
Freeman-Cook KD, Autry C, Borzillo G, et al: Design of selective, ATP-competitive inhibitors of Akt. J Med Chem 53: 4615-4622, 2010.
-
(2010)
J Med Chem
, vol.53
, pp. 4615-4622
-
-
Freeman-Cook, K.D.1
Autry, C.2
Borzillo, G.3
|