-
1
-
-
33745604956
-
Interaction between the epidermal growth factor receptor EGFR and the vascular endothelial growth factor VEGF pathways: A rational approach for multi-target anticancer therapy
-
Ciardiello F, Troiani T, Bianco R, et al. Interaction between the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor (VEGF) pathways: a rational approach for multi-target anticancer therapy. Ann Oncol 2006;12(Suppl 7):109-14
-
(2006)
Ann. Oncol.
, vol.12
, Issue.7
, pp. 109-114
-
-
Ciardiello, F.1
Troiani, T.2
Bianco, R.3
-
3
-
-
66149163097
-
Combined vascular endothelial growth factor receptor and epidermal growth factor receptor EGFR blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
-
Naumov GN, Nilsson MB, Cascone T, et al. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res 2009;15:3484-94
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3484-3494
-
-
Naumov, G.N.1
Nilsson, M.B.2
Cascone, T.3
-
4
-
-
79957823572
-
Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy BeTa: A double-blind placebo-controlled phase 3 trial
-
Hainsworth J, Herbst RS, Ansari R, et al. Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial. J Lancet 2011;28:377(9780):1846-54
-
(2011)
J. Lancet.
, vol.28-377
, Issue.9780
, pp. 1846-1854
-
-
Hainsworth, J.1
Herbst, R.S.2
Ansari, R.3
-
5
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355: 2542-50 (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
6
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
DOI 10.1200/JCO.2004.11.022
-
Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22: 2184-91 (Pubitemid 41095154)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.11
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
Herbst, R.S.4
Nemunaitis, J.J.5
Jablons, D.M.6
Langer, C.J.7
DeVore III, R.F.8
Gaudreault, J.9
Damico, L.A.10
Holmgren, E.11
Kabbinavar, F.12
-
7
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
8
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32 (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
9
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling angiogenesis and tumor growth following oral administration
-
Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55
-
(2002)
Cancer Res.
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
-
10
-
-
23844544081
-
Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
-
DOI 10.1093/annonc/mdi247
-
Holden SN, Eckhardt SG, Basser R, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005;16:1391-7 (Pubitemid 41158486)
-
(2005)
Annals of Oncology
, vol.16
, Issue.8
, pp. 1391-1397
-
-
Holden, S.N.1
Eckhardt, S.G.2
Basser, R.3
De Boer, R.4
Rischin, D.5
Green, M.6
Rosenthal, M.A.7
Wheeler, C.8
Barge, A.9
Hurwitz, H.I.10
-
11
-
-
33846844387
-
A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
-
PII 0124389420061100000014
-
Tamura T, Minami H, Yamada Y, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thorac Oncol 2006;1:1002-9 (Pubitemid 47181370)
-
(2006)
Journal of Thoracic Oncology
, vol.1
, Issue.9
, pp. 1002-1009
-
-
Tamura, T.1
Minami, H.2
Yamada, Y.3
Yamamoto, N.4
Shimoyama, T.5
Murakami, H.6
Horiike, A.7
Fujisaka, Y.8
Shinkai, T.9
Tahara, M.10
Kawada, K.11
Ebi, H.12
Sasaki, Y.13
Jiang, H.14
Saijo, N.15
-
12
-
-
41749097667
-
A randomized, double-blind, phase IIa dose-finding study of vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
-
DOI 10.1097/JTO.0b013e318168d228, PII 0124389420080400000011
-
Kiura K, Nakagawa K, Shinkai T, et al. A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. J Thorac Oncol 2008;3:386-93 (Pubitemid 351489479)
-
(2008)
Journal of Thoracic Oncology
, vol.3
, Issue.4
, pp. 386-393
-
-
Kiura, K.1
Nakagawa, K.2
Shinkai, T.3
Eguchi, K.4
Ohe, Y.5
Yamamoto, N.6
Tsuboi, M.7
Yokota, S.8
Seto, T.9
Jiang, H.10
Nishio, K.11
Saijo, N.12
Fukuoka, M.13
-
13
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim ES, Herbst RS, Wistuba II, et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 2011;1:44-53
-
(2011)
Cancer Discov.
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
-
14
-
-
66349087009
-
Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part double-blind randomized phase II study
-
Natale RB, Bodkin D, Govindan R, et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase II study. J Clin Oncol 2009;27:2523-9
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2523-2529
-
-
Natale, R.B.1
Bodkin, D.2
Govindan, R.3
-
15
-
-
34948838898
-
Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non-small-cell lung cancer
-
DOI 10.1200/JCO.2006.10.5122
-
Heymach JV, Johnson BE, Prager D, et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 2007;25:4270-7 (Pubitemid 47548567)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.27
, pp. 4270-4277
-
-
Heymach, J.V.1
Johnson, B.E.2
Prager, D.3
Csada, E.4
Roubec, J.5
Pesek, M.6
Spasova, I.7
Belani, C.P.8
Bodrogi, I.9
Gadgeel, S.10
Kennedy, S.J.11
Hou, J.12
Herbst, R.S.13
-
16
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride OSI-774 combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-9
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
17
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva lung cancer investigation trial
-
DOI 10.1200/JCO.2005.05.1474
-
Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-52 (Pubitemid 46733081)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.12
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
Kaukel, E.4
Roubec, J.5
De Rosa, F.6
Milanowski, J.7
Karnicka-Mlodkowski, H.8
Pesek, M.9
Serwatowski, P.10
Ramlau, R.11
Janaskova, T.12
Vansteenkiste, J.13
Strausz, J.14
Manikhas, G.M.15
Von Pawel, J.16
-
18
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
DOI 10.1200/JCO.2004.07.215
-
Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004;22:785-94 (Pubitemid 41103589)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
Scagliotti, G.7
Rosell, R.8
Oliff, I.9
Reeves, J.A.10
Wolf, M.K.11
Krebs, A.D.12
Averbuch, S.D.13
Ochs, J.S.14
Grous, J.15
Fandi, A.16
Johnson, D.H.17
-
19
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
DOI 10.1200/JCO.2004.08.001
-
Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004;22:777-84 (Pubitemid 41103588)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
Natale, R.B.7
Schiller, J.H.8
Von Pawel, J.9
Pluzanska, A.10
Gatzemeier, U.11
Grous, J.12
Ochs, J.S.13
Averbuch, S.D.14
Wolf, M.K.15
Rennie, P.16
Fandi, A.17
Johnson, D.H.18
-
20
-
-
56749102822
-
Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
-
Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008;26:5407-15
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 5407-5415
-
-
Heymach, J.V.1
Paz-Ares, L.2
De Braud, F.3
-
21
-
-
79952748468
-
Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
-
Natale RB, Thongprasert S, Greco FA, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011;29:1059-66
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 1059-1066
-
-
Natale, R.B.1
Thongprasert, S.2
Greco, F.A.3
-
22
-
-
78049395323
-
Vandetanib versus placebo in patients with advanced non-small cell lung cancer NSCLC after prior therapy with an EGFR tyrosine kinase inhibitor TKI: A randomized double-blind phase III trial ZEPHYR
-
Suppl: abstract 7525
-
Lee J, Hirsh V, Park K, et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): a randomized, double-blind phase III trial (ZEPHYR).J Clin Oncol 2010;28(Suppl):abstract 7525
-
(2010)
J. Clin. Oncol.
, vol.28
-
-
Lee, J.1
Hirsh, V.2
Park, K.3
-
23
-
-
77954035012
-
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer ZODIAC: A double-blind randomised phase 3 trial
-
Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11:619-26
-
(2010)
Lancet. Oncol.
, vol.11
, pp. 619-626
-
-
Herbst, R.S.1
Sun, Y.2
Eberhardt, W.E.3
-
24
-
-
79952742483
-
Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized double-blind phase III trial
-
de Boer RH, Arrieta O, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. J Clin Oncol 2011;29:1067-74
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 1067-1074
-
-
De Boer, R.H.1
Arrieta, O.2
Yang, C.H.3
-
25
-
-
42549116071
-
Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma a retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer NSCLC
-
Peterson P, Park K, Fossella F, et al. Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC).J Thorac Oncol 2007;2:s851
-
(2007)
J. Thorac. Oncol.
, vol.2
-
-
Peterson, P.1
Park, K.2
Fossella, F.3
-
26
-
-
77955123488
-
A phase I study of vandetanib in combination with vinorelbine cisplatin or gemcitabine cisplatin as first-line treatment for advanced non-small cell lung cancer
-
Blackhall FH, O'Brien M, Schmid P, et al. A phase I study of vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. J Thorac Oncol 2010;5:1285-8
-
(2010)
J. Thorac. Oncol.
, vol.5
, pp. 1285-1288
-
-
Blackhall, F.H.1
O'Brien, M.2
Schmid, P.3
-
27
-
-
61649116935
-
An open-label study of vandetanib with pemetrexed in patients with previously treated non-small-cell lung cancer
-
de Boer R, Humblet Y, Wolf J, et al. An open-label study of vandetanib with pemetrexed in patients with previously treated non-small-cell lung cancer. Ann Oncol 2009;20:486-91
-
(2009)
Ann. Oncol.
, vol.20
, pp. 486-491
-
-
De Boer, R.1
Humblet, Y.2
Wolf, J.3
|