Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways

Experimental and Molecular Pathology

Volumn 93, Issue 1, 2012, Pages 1-7

  Vivar, Raúl ^a   Humeres, Claudio ^a   Varela, Marcelo ^a   Ayala, Pedro ^a   Guzmán, Nancy ^a   Olmedo, Ivonne ^a   Catalán, Mabel ^a   Boza, Pía ^a   Muñoz, Claudia ^a   Díaz Araya, Guillermo ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Apoptosis; Cardiac fibroblast; IGF 1; Ischemia reperfusion

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CARDIAC FIBROBLAST; CELL ISOLATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; ISCHEMIA; NEWBORN; NONHUMAN; RAT; REPERFUSION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELLS, CULTURED; CHROMONES; ENZYME INHIBITORS; FIBROBLASTS; FLAVONOIDS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REPERFUSION INJURY;

RATTUS;

EID: 84860690851     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.01.010     Document Type: Article

References (42)

1. Bogoyevitch M.A., Gillespie-Brown J., Ketterman A.J., Fuller S.J., Ben-Levy R., Ashworth A., Marshall C.J., Sudgen P.H. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart: p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Circulation Research 1996, 79:162-173.
2. Brar B.K., Jonassen A.K., Stephanou A., Santilli G., Railson J., Knight R., Yellon D., Latchman D.S. Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. The Journal of Biological Chemistry 2000, 275:8508-8514.
3. Brar B.K., Stephanou A., Liao Z., O'Leary R.M., Pennica D., Yellon D.M., Latchman D.S. Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation. Cardiovascular Research 2001, 51:265-274.
4. Braunwald E., Kloner R.A. Myocardial reperfusion: a double-edged sword?. The Journal of Clinical Investigation 1985, 76:1713-1719.
5. Buerke M., Murohara T., Skurk C., Nuss C., Tomaselli K., Lefer A.M. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proceedings of the National Academy of Sciences 1995, 92:8031-8035.
6. Buja L.M. Modulation of the myocardial response to ischemia. Laboratory Investigation 1998, 78:1345-1373.
7. Chohan P.K., Singh R.B., Dhalla N.S., Netticadan T. l-Arginine administration recovers sarcoplasmic reticulum function in ischemic reperfused hearts by preventing calpain activation. Cardiovascular Research 2006, 69:152-163.
8. Cross T.G., Scheel-Toellner D., Henriquez N.V., Deacon E., Salmon M., Lord J.M. Serine/threonine protein kinases and apoptosis. Experimental Cell Research 2000, 256:34-41.
9. Defer N., Wan J., Souktani R., Escoubet B., Perier M., Caramelle P., Manin S., Deveaux V., Bourin M.C., Zimmer A., Lotersztajn S., Pecker F., Pavoine C. The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy. The FASEB Journal 2009, 23:2120-2130.
10. Engelbrecht A.M., Niesler C., Page C., Lochner A. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Research in Cardiology 2004, 99:338-350.
11. Fliss H., Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circulation Research 1996, 79:949-956.
12. Fujio Y., Nguyen T., Wencker D., Kitsis R.N., Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000, 101:660-667.
13. Gores G.J., Nieminen A.L., Wray B.E., Herman B., Lemasters J.J. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes: protection by intracellular acidosis against the onset of cell death. The Journal of Clinical Investigation 1989, 83:386-396.
14. Gottlieb R.A., Burleson K.O., Kloner R.A., Babior B.M., Engler R.L. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. The Journal of Clinical Investigation 1994, 94:1621-1628.
15. Guyton K.Z., Liu Y., Gorospe M., Xu Q., Holbrook N.J. Activation of mitogen-activated protein kinase by HO. The Journal of Biological Chemistry 1996, 271:4138-4142.
16. Halestrap A.P. Calcium, mitochondria and reperfusion injury: a pore way to die. Biochemical Society Transactions 2006, 34:232-237.
17. Hanlon P.R., Fu P., Wright G.L., Steenberg C., Arcasoy M.O., Murphy E. Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. The FASEB Journal 2005, 19:1323-1325.
18. Hausenloy D.J., Yellon D.M. Cardioprotective growth factors. Cardiovascular Research 2009, 83:179-194.
19. Jolly S.R., Kane W.J., Bailie M.B., Abrams G.D., Lucchesi B.R. Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase. Circulation Research 1984, 54:277-285.
20. Kubasiak L.A., Hernandez O.M., Bishopric N.H., Webster K.A. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proceedings of the National Academy of Sciences 2002, 99:12825-12830.
21. Kulik G., Klippel A., Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Molecular and Cellular Biology 1997, 17:1595-1606.
22. Li P., Wang D., Lucas J., Oparil S., Xing D., Cao X., Novak L., Renfrow M.B., Chen Y. Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circulation Research 2008, 102:185-192.
23. Matsui T., Li L., Monte F., Fukui Y., Franke T.F., Hajjar R.J., Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 1999, 100:2373-2379.
24. Mockridge J.W., Benton E.C., Andreeva L.V., Latchman D.S., Marber M.S., Heads R.J. IGF-1 regulates cardiac fibroblast apoptosis induced by osmotic stress. Biochemical and Biophysical Research Communications 2000, 273:322-327.
25. Pang L., Sawada T., Decker S.J., Saltiel A.R. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. The Journal of Biological Chemistry 1995, 270:13585-13588.
26. Parrizas M., Saltiel A.R., Leroith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. The Journal of Biological Chemistry 1997, 272:154-161.
27. Pieczenik S.R., Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Experimental and Molecular Pathology 2007, 83:84-92.
28. Powell S.R., Wang P., Katzeff H., Shringarpure R., Teoh C., Khaliulin I., Das D.K., Kelvin J.A., Schwalb H. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxidants & Redox Signaling 2005, 7:538-546.
29. Punn A., Mockridge J.W., Farooqui S., Marber M.S., Heads R.J. Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. The Biochemical Journal 2000, 15:891-899.
30. Singh R.B., Chohan P.K., Dhalla N.S., Netticadan T. The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart. Journal of Molecular and Cellular Cardiology 2004, 37:101-110.
31. Stephanou A., Brar B., Liao Z., Scarabelli T., Knight R.A., Latchman D.S. Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury. Cell Death and Differentiation 2001, 8:434-435.
32. Takeda N., Manabe I., Uchino Y., Eguchi K., Matsumoto S., Nishimura S., Shindo T., Sano M., Otsu K., Snider P., Conway S.J., Nagai R. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. The Journal of Clinical Investigation 2010, 4:254-265.
33. Vanden Hoek T.L., Shao Z., Li C., Zak R., Schumacker P.T., Becker L.B. Reperfusion injury on cardiac myocytes after simulated ischemia. American Journal of Physiology. Heart and Circulatory Physiology 1996, 270:1334-1341.
34. Vivar R., Soto C., Copaja M., Mateluna F., Aranguiz P., Muñoz J., Chiong M., Garcia L., Letelier A., Walter T., Lavandero S., Diaz-Araya G. Phospholipase C/protein kinase c pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor. Journal of Cardiovascular Pharmacology 2008, 52:184-190.
35. Wang L., Ma W., Markovich R., Lee W.L., Wang P.H. Insulin-like growth factor I modulates induction of apoptotic signaling in H9C2 cardiac muscle cells. Endocrinology 1998, 139:1354-1360.
36. Wang L., Ma W., Markovich R., Chen J.W., Wang P.H. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circulation Research 1998, 83:516-522.
37. Weber K.T. Fibrosis in hypertensive heart disease: focus on cardiac fibroblasts. Journal of Hypertension 2004, 22:47-50.
38. Yao R., Cooper G.M. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995, 267:2003-2006.
39. Yaoita H., Ogawa K., Maehara K., Maruyama Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 1998, 97:276-281.
40. Yellon D.M., Hausenloy D.J. Myocardial reperfusion injury. The New England Journal of Medicine 2007, 357:1121-1135.
41. Yue T.-L., Wang C., Gu J.-L., Ma X.-L., Kumar S., Lee J.C., Fuerstein G.Z., Thomas H., Maleef B., Ohlstein E.H. Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circulation Research 2000, 86:692-699.
42. Zweier J.L., Kuppusamy P., Williams R., Rayburn B.K., Smith D., Wiesfeldt M.L., Flaherty J.T. Measurement and characterization of postischemic free radical generation in the isolated perfused heart. The Journal of Biological Chemistry 1989, 264:18890-18895.