Suppression of estrogen receptor-alpha transactivation by thyroid transcription factor-2 in breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 421, Issue 3, 2012, Pages 532-537

  Park, Eunsook ^a   Gong, Eun Yeung ^a   Romanelli, Maria Grazia ^b   Lee, Keesook ^a  

^a Chonnam National University   (South Korea)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Breast cancer; Cell proliferation; Coregulator; Estrogen receptor; Thyroid transcription factor 2

Indexed keywords

CYCLIN D1; ESTROGEN RECEPTOR ALPHA; THYROID TRANSCRIPTION FACTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CANCER CELL; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN MCF 7; COMPLEX FORMATION; CONCENTRATION RESPONSE; FEMALE; GENE REPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; THIRD TRIMESTER PREGNANCY; TRANSACTIVATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ESTROGEN RECEPTOR ALPHA; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPRECIPITATION; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; MICE; MICE, INBRED ICR; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTIONAL ACTIVATION;

EID: 84860682314     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.039     Document Type: Article

References (29)

1. Nilsson S., Makela S., Treuter E., et al. Mechanisms of estrogen action. Physiol. Rev. 2001, 81:1535-1565.
2. Couse J.F., Korach K.S. Estrogen receptor null mice: what have we learned and where will they lead us?. Endocr. Rev. 1999, 20:358-417.
3. Bocchinfuso W.P., Hively W.P., Couse J.F., et al. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res. 1999, 59:1869-1876.
4. Kumar V., Green S., Stack G., et al. Functional domains of the human estrogen receptor. Cell 1987, 51:941-951.
5. Gronemeyer H. Transcription activation by estrogen and progesterone receptors. Annu. Rev. Genet. 1991, 25:89-123.
6. Jakowlew S.B., Breathnach R., Jeltsch J.M., et al. Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. Nucleic Acids Res. 1984, 12:2861-2878.
7. Kastner P., Krust A., Turcotte B., et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 1990, 9:1603-1614.
8. Augereau P., Miralles F., Cavailles V., et al. Characterization of the proximal estrogen-responsive element of human cathepsin D gene. Mol. Endocrinol. 1994, 8:693-703.
9. Neuman E., Ladha M.H., Lin N., et al. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol. 1997, 17:5338-5347.
10. Ding L., Yan J., Zhu J., et al. Ligand-independent activation of estrogen receptor alpha by XBP-1. Nucleic Acids Res. 2003, 31:5266-5274.
11. Fan S., Ma Y.X., Wang C., et al. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene 2001, 20:77-87.
12. Zheng L., Annab L.A., Afshari C.A., et al. BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc. Natl. Acad. Sci. USA 2001, 98:9587-9592.
13. Civitareale D., Saiardi A., Falasca P. Purification and characterization of thyroid transcription factor 2. Biochem. J. 1994, 304(Pt 3):981-985.
14. Zannini M., Avantaggiato V., Biffali E., et al. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997, 16:3185-3197.
15. Perrone L., Pasca di Magliano M., Zannini M., et al. The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor. Biochem. Biophys. Res. Commun. 2000, 275:203-208.
16. Dathan N., Parlato R., Rosica A., et al. Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair. Dev. Dyn. 2002, 224:450-456.
17. Sequeira M., Al-Khafaji F., Park S., et al. Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis. Thyroid 2003, 13:927-932.
18. Bamforth J.S., Hughes I.A., Lazarus J.H., et al. Congenital hypothyroidism, spiky hair, and cleft palate. J. Med. Genet. 1989, 26:49-51.
19. Romanelli M.G., Tato L., Lorenzi P., et al. Nuclear localization domains in human thyroid transcription factor 2. Biochim. Biophys. Acta 2003, 1643:55-64.
20. Lee S.Y., Gong E.Y., Hong C.Y., et al. ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation. Free Radic. Biol. Med. 2009, 47:1591-1600.
21. Baron U., Freundlieb S., Gossen M., et al. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res. 1995, 23:3605-3606.
22. Wijayaratne A.L., McDonnell D.P. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J. Biol. Chem. 2001, 276:35684-35692.
23. Kurebayashi J., Otsuki T., Kunisue H., et al. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer. Clin. Cancer Res. 2000, 6:512-518.
24. Bagheri-Yarmand R., Talukder A.H., Wang R.A., et al. Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Development 2004, 131:3469-3479.
25. Mazumdar A., Wang R.A., Mishra S.K., et al. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat. Cell Biol. 2001, 3:30-37.
26. Prall O.W., Rogan E.M., Sutherland R.L. Estrogen regulation of cell cycle progression in breast cancer cells. J. Steroid Biochem. Mol. Biol. 1998, 65:169-174.
27. Maurer P., T'Sas F., Coutte L., et al. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. Oncogene 2003, 22:3319-3329.
28. Yeung K., Kim S., Reinberg D. Functional dissection of a human Dr1-DRAP1 repressor complex. Mol. Cell. Biol. 1997, 17:36-45.
29. Briata P., Ilengo C., Van DeWerken R., et al. Mapping of a potent transcriptional repression region of the human homeodomain protein EVX1. FEBS Lett. 1997, 402:131-135.