Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy

Epilepsia

Volumn 53, Issue 5, 2012, Pages

  Berretta, Nicola ^a   Ledonne, Ada ^a   Mango, Dalila ^a   Bernardi, Giorgio ^a,b   Mercuri, Nicola B ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Cross correlation; Multielectrode array; NR2 subunits

Indexed keywords

4 AMINOPYRIDINE; [[1 (4 BROMOPHENYL)ETHYLAMINO](2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALIN 5 YL)METHYL]PHOSPHONIC ACID; ALPHA (4-HYDROXYPHENYL) BETA METHYL 4 (PHENYLMETHYL) 1 PIPERIDINEPROPANOL MALEATE; MALEIC ACID DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPTOGENESIS; HIPPOCAMPUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPORAL LOBE EPILEPSY;

2-AMINO-5-PHOSPHONOVALERATE; ACTION POTENTIALS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENTORHINAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; NEURAL PATHWAYS; PATCH-CLAMP TECHNIQUES; PHENOLS; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84860666821     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2012.03420.x     Document Type: Article

References (13)

1. Avoli M, D'Antuono M, Louvel J, Köhling R, Biagini G, Pumain R, D'Arcangelo G, Tancredi V,. (2002) Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Prog Neurobiol 68: 167-207.
2. Borbély S, Dobõ E, Czégé D, Molnár E, Bakos M, Szucs B, Vincze A, Világi I, Mihály A,. (2009) Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Neuroscience 159: 358-368.
3. Borck C, Jefferys JGR,. (1999) Seizure-like events in disinhibited ventral slices of adult rat hippocampus. J Neurophysiol 82: 2130-2142.
4. Bragin A, Csicsvári J, Penttonen M, Buzsáki G,. (1997) Epileptic afterdischarge in the hippocampal-entorhinal system: current source density and unit studies. Neuroscience 76: 1187-1203.
5. Chamberlain SE, Yang J, Jones RS,. (2008) The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex. Neural Plast 2008: 872456.
6. Chen Q, He S, Hu XL, Yu J, Zhou Y, Zheng J, Zhang S, Zhang C, Duan WH, Xiong ZQ,. (2007) Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. J Neurosci 27: 542-552.
7. Fischer G, Mutel V, Trube G, Malherbe P, Kew JN, Mohacsi E, Heitz MP, Kemp JA,. (1997) Ro 25-6981, a highly potent and selective blocker of N-methyl-d-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283: 1285-1292.
8. Frasca A, Aalbers M, Frigerio F, Fiordaliso F, Salio M, Gobbi M, Cagnotto A, Gardoni F, Battaglia GS, Hoogland G, Di Luca M, Vezzani A,. (2011) Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity. Neurobiol Dis 43: 507-515.
9. Gibbs S, Chattopadhyaya B, Desgent S, Awad PN, Clerk-Lamalice O, Levesque M, Vianna RM, Rébillard RM, Delsemme AA, Hébert D, Tremblay L, Lepage M, Descarries L, Di Cristo G, Carmant L,. (2011) Long-term consequences of a prolonged febrile seizure in a dual pathology model. Neurobiol Dis 43: 312-321.
10. Gonzalez-Sulser A, Wang J, Motamedi GK, Avoli M, Vicini S, Dzakpasu R,. (2011) The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Neuropharmacology 60: 1142-1153.
11. Isomura Y, Fujiwara-Tsukamoto Y, Takada M,. (2008) A network mechanism underlying hippocampal seizure-like synchronous oscillations. Neurosci Res 61: 227-233.
12. Jones RS, Heinemann U,. (1988) Synaptic and intrinsic responses of medical entorhinal cortical cells in normal and magnesium-free medium in vitro. J Neurophysiol 59: 1476-1496.
13. Neyton J, Paletti P,. (2006) Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci 26: 1331-1333.