Determination of the plasma pharmacokinetic and tissue distributions of swertiamarin in rats by liquid chromatography with tandem mass spectrometry

Arzneimittel-Forschung/Drug Research

Volumn 62, Issue 3, 2012, Pages 138-144

  Li, H L ^a   He, J C ^a   Bai, M ^a   Song, Q Y ^a   Feng, E F ^a   Rao, G X ^b   Xu, G L ^a,c  

^a KUNMING GENERAL HOSPITAL   (China)

^b YUNNAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c TIANJIN UNIVERSITY   (China)

Author keywords

CAS 17388 39 5; LC MS MS; plasma; rat; tissues

Indexed keywords

ACETIC ACID; GENTIOPICRIN; METHANOL; SWERTIAMARIN; WATER; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IRIDOID; PYRONE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG MONITORING; DRUG STABILITY; DRUG TISSUE LEVEL; ELECTROSPRAY; FEMALE; FLOW RATE; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; SPRAGUE DAWLEY RAT; STANDARD; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; VALIDATION PROCESS; ANIMAL; BIOAVAILABILITY; BLOOD; CALIBRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; QUALITY CONTROL; REPRODUCIBILITY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INDICATORS AND REAGENTS; INJECTIONS, INTRAVENOUS; IRIDOID GLUCOSIDES; PYRONES; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84860641431     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1298021     Document Type: Article

References (12)

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