"Immune activation, aging and gender" and progression of liver disease

Acta Biomedica

Volumn 82, Issue 2, 2011, Pages 115-123

  Nasta, Paola ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Aging; HIV HCV co infection; Progression of liver disease

Indexed keywords

ATAZANAVIR PLUS RITONAVIR; CHEMOKINE RECEPTOR CCR5; EMTRICITABINE; ESTROGEN; MARAVIROC; PEGINTERFERON; RIBAVIRIN; TENOFOVIR;

AGING; DISEASE COURSE; DISEASE SEVERITY; FATTY LIVER; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LIVER CANCER; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; MENOPAUSE; METABOLIC DISORDER; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SEX DIFFERENCE; VIRUS LOAD; VIRUS REPLICATION; ADULT; AMENORRHEA; COMORBIDITY; DRUG ANTAGONISM; FEMALE; IMMUNOLOGY; MALE; MIXED INFECTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AMENORRHEA; COINFECTION; COMORBIDITY; DISEASE PROGRESSION; ESTROGENS; FEMALE; HEPATITIS C, CHRONIC; HIV INFECTIONS; HUMANS; LIVER DISEASES; MALE; RECEPTORS, CCR5; SEX FACTORS;

EID: 84860580525     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Massard J, Ratziu V, Thabut D, et al. Natural history and predictors of disease severity in chronic hepatitis C. J Hepatol 2006; 44 (Suppl 1): S19-24.
2. Strader DB, Wright T, Thomas DL, et al. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004; 39: 1147-71.
3. Asselah T, Boyer L, Gulmont MC, et al. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Gut 2003; 52: 1638-43.
4. Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002; 36: S35-46.
5. Ramesh S, Sanyal AJ. Evaluation and management of nonalcoholic steatohepatitis. J Hepatol 2005; 42: S2-12.
6. Ferrari C, Urbani S, Penna A, et al. Immunopathogenesis of hepatitis C virus infection. Hepatology 1999; 29: 719-27.
7. Adinolfi LE, Gambardella M, Andreana A. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-64.
8. Sato S, Genda T, Hirano K, et al. Differences in the factors associated with serum viral load between genotypes 1 and 2 in patients with chronic hepatitis C. Hepatol Int 2011 Epub Ahed of prints.
9. Ramcharran D, Wahed AS, Conjeevaram HS, et al. Serum lipids and their associations with viral levels and liver disease severity in a treatment-naïve chronic hepatitis C type 1-infected cohort. J Viral Hepat 2011; 18 (4): e144-52.
10. Moucar R, Asselah T, Cazals-Hatem D, et al. Insulin resistance in chronich hepatitis C: association with genotype 1-4,serum HCV-RNA level, and liver fibrosis. Gastroneterology 2008; 134: 416-23.
11. Nasta P, Gatti F, Borghi F. Insulin resistance is associated with hepatitis C viremia and redeces the success of peginterferoen alfa 2a plus ribavirin in HIV/HCV coinfected patients. 50th ICAAC, 12-15 September 2010; Boston MA.
12. Bridge SH, Sheridan DA, Felmlee DJ, et al. Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection. Gut 201; 60: 680-7.
13. Cassman D, Roskams T.Beauty is in the eye of the beholder: emergine concepts and pitfails in hepatic stellate cell research. J Hepatol 2002; 37: 397-416.
14. Pinzani M, Marra F. Cytokine receptors and signalling in hepatic stellate cells Semin Liver Dis 2001; 21: 397-416.
15. Marra F. Chemokines in liver inflammation and fibrosis. Fron Biosci 2002; 7: d1899-1914.
16. Smit-McBride Z, Mattapallil JJ, McChesney M, et al. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J Virol 1998; 72: 6646-56.
17. Veazey RS, DeMaria M, Chalifoux LV, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998; 280: 427-31.
18. Sun ZF, Denton PW, Estes JD, et al. Intrarectal transmission, systemic infection, and CD4(+) T celldepletion in humanized mice infected with HIV-1. J Exp Med 2007; 204: 705-14.
19. Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4(+) T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004; 200: 761-70.
20. Guadalupe M, Reay E, Sankaran S, et al. Severe CD4(+) T-cell depletion in gut lymphoid tissue duringprimary human immunodeficiency virus type 1 infection and substantial delay in restoration followinghighly active antiretroviral therapy. J Virol 2003; 77: 11708-17.
21. Kewenig S, Schneider T, Hohloch K, et al. Rapid mucosal CD4(+) T-cell depletion and enteropathyin simian immunodeficiency virus-infected rhesus macaques. Gastroenterology 1999; 116: 1115-23.
22. Pinzani M, Falli P, Rocco C, et al. Fat storing cells as liver specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transiente. J Clin Invest 1992; 90: 642-46.
23. Sandler N, et al Plasma soluble sCD14 levels are associated with severity of liver diseases and predict clinical out-come in HBV and HCV infection. CROI 2011; #939
24. Balagopal A, Philp F, Astemborski J. Human Immunodeficiency Virus-related Microbial Translocation and Progression of Hepatitis C: HIV, HCV, Microbial Translocation and Liver Disease. Gastroenterology 2008; 135 (1): 226-33.
25. Marchetti G, Nasta P, et al. Role of Microbial Translocation in the Virological Response to Pegylated Interferon a and Ribavirin in HIV/HCV Coinfected Patients. Submitted
26. Poynard T, Ratziu V, Charlotte F, et al. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c. J Hepatol 2001; 34: 730-9.
27. Villa E, Karampatoua A, Cammà C, et al. Early Menopause Is Associated With Lack of Response to Antiviral Therapy in Women With Chronic Hepatitis C. Gastroenterology 2011; 140: 818-29.
28. Pfeilschifter J, Koditz R, Pfohl M, et al. Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002; 23: 90-119.
29. Pinkus R, Weiner LM, Daniel V. Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression. J Biol Chem 1996; 271: 13422-9.
30. Omoya T, Shimizu I, Zhou Y, et al. Effects of idoxifene and estradiol on NF-kappaB activation in cultured rat hepatocytes undergoing oxidative stress. Liver 2001; 21: 183-91.
31. Inoue H, Shimizu I, Lu G, et al. Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptorbeta in cultured rat hepatocytes. Dig Dis Sci 2003; 48: 570-80.
32. Kilbourne EJ, Scicchitano MS. The activation of plasminogen activator inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen receptor alpha. Thromb Haemost 1999; 81: 423-7.
33. Ying Yuan, Ichiro Shimizu, Mi Shen. et al. Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C. World J Gastroenterol 2008; 14: 2200-7.
34. Rogers A, Eastell R.The effect of 17beta-estradiol on production of cytokines in cultures of peripheral blood. Bone 2001; 29: 30-34
35. Brannstrom M, Friden BE, Jasper M, et al. in peripheral blood levels of immunoreactive tumor necrosis factor alpha (TNFalpha) throughout the menstrual cycle and secretion of TNFalpha from the human corpus luteum. Eur J Obstet Gynecol Reprod Biol 1999; 83: 213-7.
36. Luther S.A and J. G Cyster. Chemokines as regulators of T cells differentiations. Nat Immunol 2001; 2: 102-7.
37. Zlotnick A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity; 2000: 12: 121-7.
38. Bruno R, Galastri S, Sacchi P, et al. gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis. Gut 2010; 59(4): 513-20.
39. Kusano F, Tanaka F, Marumo F, et al. Expression of C-C chemokine is associated with portal and periportal inflammation in the liver of patients with chronich hepatitis C. Lab Invest 2000; 80: 415-22.
40. Lechner F, Guener S, Urbani J. CD8+T lymphocytes response are induced during acute hepatitis C virus infection but are not sustained. Eur J Immunol 2000; 30: 2479-87.
41. Ekiro S, Seki E, De Minicis S, et al. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest 2009; 119: 1858-70.
42. Nasta P, Gatti F, Borghu F, et al. Maraviroc (MVC) reduces liver stiffness (LS) in HIV-hepatitis C (HCV) coinfected patients. IAS 2011, Rome 18-20 July 2011, We-BA0105.