PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20

Cellular Immunology

Volumn 275, Issue 1-2, 2012, Pages 12-18

  Nicholson, Ian C ^a,b,c   Mavrangelos, Christos ^a,b   Bird, Daniel R G ^a,b   Bresatz Atkins, Suzanne ^a,b   Eastaff Leung, Nicola G ^a,b,c   Grose, Randall H ^a,b   Gundsambuu, Batjargal ^a,b   Hill, Danika ^a,b   Millard, Debbrah J ^a,b   Sadlon, Timothy J ^a,c   To, Sarah ^a,b   Zola, Heddy ^a,b,c   Barry, Simon C ^a,b,c   Krumbiegel, Doreen ^a,b,c  

^a CHILD HEALTH RESEARCH INSTITUTE   (Australia)

^b Co operative Research Centre for Biomarker Translation ^*  (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Lymphocyte migration; Memory Treg; Peptidase inhibitor 16; Regulatory T cells

Indexed keywords

CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; ENZYME INHIBITOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCLONAL ANTIBODY; PROTEIN PI16; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ARTICLE; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE MIGRATION; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ANTIGENS, CD45; CARRIER PROTEINS; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CCL17; CHEMOKINE CCL20; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; GLYCOPROTEINS; HUMANS; IMMUNOLOGIC MEMORY; PHENOTYPE; T-LYMPHOCYTES, REGULATORY;

EID: 84860551956     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2012.04.002     Document Type: Article

References (30)

1. Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 2010, 11:7-13.
2. Hoffmann P., Ermann J., Edinger M. CD4+CD25+ regulatory T cells in hematopoietic stem cell transplantation. Curr. Top. Microbiol. Immunol. 2005, 293:265-285.
3. Putnam A.L., Brusko T.M., Lee M.R., Liu W., Szot G.L., Ghosh T., Atkinson M.A., Bluestone J.A. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 2009, 58:652-662.
4. Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., Kelly T.E., Saulsbury F.T., Chance P.F., Ochs H.D. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27:20-21.
5. Fontenot J.D., Gavin M.A., Rudensky A.Y. FoxP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336.
6. Roncador G., Brown P.J., Maestre L., Hue S., Martinez-Torrecuadrada J.L., Ling K.L., Pratap S., Toms C., Fox B.C., Cerundolo V., Powrie F., Banham A.H. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 2005, 35:1681-1691.
7. Presicce P., Moreno-Fernandez M.E., Lages C.S., Orsborn K.I., Chougnet C.A. Association of two clones allows for optimal detection of human FOXP3. Cytometry A 2010, 77:571-579.
8. Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25 high regulatory cells in human peripheral blood. J. Immunol. 2001, 167:1245-1253.
9. Hoffmann P., Eder R., Boeld T.J., Doser K., Piseshka B., Andreesen R., Edinger M. Only the CD45RA+ subpopulation of CD4+CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006, 108:4260-4267.
10. Cantrell D.A., Smith K.A. Transient expression of interleukin 2 receptors. Consequences for T cell growth. J. Exp. Med. 1983, 158:1895-1911.
11. Poulton T.A., Gallagher A., Potts R.C., Beck J.S. Changes in activation markers and cell membrane receptors on human peripheral blood T lymphocytes during cell cycle progression after PHA stimulation. Immunology 1988, 64:419-425.
12. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., Fazekas de St Groth B., Clayberger C., Soper D.M., Ziegler S.F., Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 2006, 203:1701-1711.
13. Seddiki N., Santner-Nanan B., Martinson J., Zaunders J., Sasson S., Landay A., Solomon M., Selby W., Alexander S.I., Nanan R., Kelleher A., Fazekas de St Groth B. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 2006, 203:1693-1700.
14. Alves N.L., van Leeuwen E.M., Derks I.A., van Lier R.A. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J. Immunol. 2008, 180:5201-5210.
15. Sallusto F., Lanzavecchia A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur. J. Immunol. 2009, 39:2076-2082.
16. Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Parizot C., Taflin C., Heike T., Valeyre D., Mathian A., Nakahata T., Yamaguchi T., Nomura T., Ono M., Amoura Z., Gorochov G., Sakaguchi S. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009, 30:899-911.
17. Sadlon T.J., Wilkinson B.G., Pederson S., Brown C.Y., Bresatz S., Gargett T., Melville E.L., Peng K., D'Andrea R.J., Glonek G.G., Goodall G.J., Zola H., Shannon M.F., Barry S.C. Genome wide identification of human FOXP3 target genes in natural regulatory T cells. J. Immunol. 2010, 185:1071-1081.
18. Reeves J.R., Xuan J.W., Arfanis K., Morin C., Garde S.V., Ruiz M.T., Wisniewski J., Panchal C., Tanner J.E. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. Biochem. J. 2005, 385:105-114.
19. Reeves J.R., Dulude H., Panchal C., Daigneault L., Ramnani D.M. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. Clin. Cancer Res. 2006, 12:6018-6022.
20. Brooks D.A., Beckman I., Bradley J., McNamara P.J., Thomas M.E., Zola H. Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. I. A hybridoma secreting antibody against a marker specific for human B lymphocytes. Clin. Exp. Immunol. 1980, 39:477-485.
21. Zola H., Neoh S.H., Mantzioris B.X., Webster J., Loughnan M.S. Detection by immunofluorescence of surface molecules present in low copy numbers. High sensitivity staining and calibration of flow cytometer. J. Immunol. Methods. 1990, 135:247-255.
22. Venken K., Thewissen M., Hellings N., Somers V., Hensen K., Rummens J.L., Stinissen P. A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J. Immunol. Methods 2007, 322:1-11.
23. Eastaff-Leung N., Mabarrack N., Barbour A., Cummins A., Barry S. FoxP3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J. Clin. Immunol. 2010, 30:80-89.
24. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., Nochy D., Debre P., Piette J.C., Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J. Immunol. 2005, 175:8392-8400.
25. Wolf A.M., Wolf D., Steurer M., Gastl G., Gunsilius E., Grubeck-Loebenstein B. Increase of regulatory T cells in the peripheral blood of cancer patients. Clin. Cancer Res. 2003, 9:606-612.
26. Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005, 54:92-99.
27. Bromley S.K., Mempel T.R., Luster A.D. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat. Immunol. 2008, 9:970-980.
28. Lim H.W., Lee J., Hillsamer P., Kim C.H. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J. Immunol. 2008, 180:122-129.
29. Singh S.P., Zhang H.H., Foley J.F., Hedrick M.N., Farber J.M. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 2008, 180:214-221.
30. Yamamoto J., Adachi Y., Onoue Y., Adachi Y.S., Okabe Y., Itazawa T., Toyoda M., Seki T., Morohashi M., Matsushima K., Miyawaki T. Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells. J. Leukoc. Biol. 2000, 68:568-574.