Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile

FEMS Immunology and Medical Microbiology

Volumn 65, Issue 1, 2012, Pages 96-104

  Vohra, Prerna ^a   Poxton, Ian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CDI; Proinflammatory; TNF

Indexed keywords

BACTERIAL PROTEIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; CYTOKINE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 42; HEAT SHOCK PROTEIN 60; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; FLAGELLUM; HOSPITAL INFECTION; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; TOXIN ANALYSIS;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; CLOSTRIDIUM DIFFICILE; CULTURE MEDIA; CYTOKINES; HUMANS; MACROPHAGES;

EID: 84860535892     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2012.00952.x     Document Type: Article

References (45)

1. Ausiello CM, Cerquetti M, Fedele G, Spensieri F, Palazzo R, Nasso M, Frezza S & Mastrantonio P (2006) Surface layer proteins from Clostridium difficile induce inflammatory and regulatory cytokines in human monocytes and dendritic cells. Microbes Infect 8: 2640-2646.
2. Auwerx J (1991) The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 47: 22-31.
3. Bartlett JG, Moon N, Chang TW, Taylor N & Onderdonk AB (1978) Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastroenterology 75: 778-782.
4. Bianco M, Fedele G, Quattrini A, Spigaglia P, Barbanti F, Mastrantonio P & Ausiello CM (2011) Immunomodulatory activities of surface layer proteins (SLPs) obtained from epidemic and hypervirulent Clostridium difficile strains. J Med Microbiol 60: 1162-1167.
5. Brown R, Collee JG & Poxton IR (1996) Bacteroides, Fusobacterium and other Gram-negative rods: anaerobic cocci; identification of anaerobes. Chapter 30 in Mackie & McCartneys's Practical Medical Microbiology (Collee JG, Fraser AG, Marmion BP & Simmons A eds), pp. 501-519. Churchill Livingstone, Edinburgh.
6. Calabi E, Calabi F, Phillips AD & Fairweather NF (2002) Binding of Clostridium difficile surface layer proteins to gastrointestinal tissues. Infect Immun 70: 5770-5778.
7. Canny G, Drudy D, Macmathuna P, O'farrelly C & Baird AW (2006) Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical. Life Sci 78: 920-925.
8. Castagliuolo I & LaMont JT (1999) Pathophysiology, diagnosis and treatment of Clostridium difficile infection. Keio J Med 48: 169-174.
9. Delmée M, Avesani V, Delferriere N & Burtonboy G (1990) Characterization of flagella of Clostridium difficile and their role in serogrouping reactions. J Clin Microbiol 28: 2210-2214.
10. Flegel WA, Müller F, Däubener W, Fischer HG, Hadding U & Northoff H (1991) Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun 59: 3659-3666.
11. Freeman J, Bauer MP, Baines SD, Corver J, Fawley WN, Goorhuis B, Kuijper EJ & Wilcox MH (2010) The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 23: 529-549.
12. George RH, Symonds JM, Dimock F, Brown JD, Arabi Y, Shinagawa N, Keighley MR, Alexander-Williams J & Burdon DW (1978) Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J 1: 695.
13. Hennequin C, Collignon A & Karjalainen T (2001a) Analysis of expression of GroEL (Hsp60) of Clostridium difficile in response to stress. Microb Pathog 31: 255-260.
14. Hennequin C, Porcheray F, Waligora-Dupriet A, Collignon A, Barc M, Bourlioux P & Karjalainen T (2001b) GroEL (Hsp60) of Clostridium difficile is involved in cell adherence. Microbiology 147: 87-96.
15. Johal SS, Solomon K, Dodson S, Borriello SP & Mahida YR (2004) Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines. J Infect Dis 189: 2110-2119.
16. Kelly CP & Kyne L (2011) The host immune response to Clostridium difficile. J Med Microbiol 60: 1070-1079.
17. Knoop FC, Owens M & Crocker IC (1993) Clostridium difficile: clinical disease and diagnosis. Clin Microbiol Rev 6: 251-265.
18. Kyne L, Warny M, Qamar A & Kelly CP (2000) Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 342: 390-397.
19. Limbago BM, Long CM, Thompson AD et al. (2009) Clostridium difficile strains from community-associated infections. J Clin Microbiol 47: 3004-3007.
20. Linevsky JK, Pothoulakis C, Keates S, Warny M, Keates AC, LaMont JT & Kelly CP (1997) IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol 273: G1333-G1340.
21. McCoubrey J & Poxton IR (2001) Variation in the surface layer proteins of Clostridium difficile. FEMS Immunol Med Microbiol 31: 131-135.
22. McFarland LV, Beneda HW, Clarridge JE & Raugi GJ (2007) Implications of the changing face of Clostridium difficile disease for health care practitioners. Am J Infect Control 35: 237-253.
23. Melo Filho AA, Souza MH, Lyerly DM, Cunha FQ, Lima AA & Ribeiro RA (1997) Role of tumor necrosis factor and nitric oxide in the cytotoxic effects of Clostridium difficile toxin A and toxin B on macrophages. Toxicon 35: 743-752.
24. Mukherjee K, Karlsson S, Burman LG & Akerlund T (2002) Proteins released during high toxin production in Clostridium difficile. Microbiology 148: 2245-2253.
25. Mulligan ME, Miller SD, McFarland LV, Fung HC & Kwok RY (1993) Elevated levels of serum immunoglobulins in asymptomatic carriers of Clostridium difficile. Clin Infect Dis 16(Suppl 4): 239-244.
26. O'Brien JB, McCabe MS, Athié-Morales V, McDonald GSA, Ní Eidhin DB & Kelleher DP (2005) Passive immunisation of hamsters against Clostridium difficile infection using antibodies to surface layer proteins. FEMS Microbiol Lett 246: 199-205.
27. Pantosti A, Cerquetti M, Viti F, Ortisi G & Mastrantonio P (1989) Immunoblot analysis of serum immunoglobulin G response to surface proteins of Clostridium difficile in patients with antibiotic-associated diarrhea. J Clin Microbiol 27: 2594-2597.
28. Péchiné S, Gleizes A, Janoir C, Gorges-Kergot R, Barc M-C, Delmée M & Collignon A (2005a) Immunological properties of surface proteins of Clostridium difficile. J Med Microbiol 54: 193-196.
29. Péchiné S, Janoir C & Collignon A (2005b) Variability of Clostridium difficile surface proteins and specific serum antibody response in patients with Clostridium difficile-associated disease. J Clin Microbiol 43: 5018-5025.
30. Péchiné S, Janoir C, Boureau H, Gleizes A, Tsapis N, Hoys S, Fattal E & Collignon A (2007) Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile. Vaccine 25: 3946-3954.
31. Péchiné S, Denève C, Le Monnier A, Hoys S, Janoir C & Collignon A (2011) Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen. FEMS Immunol Med Microbiol 63: 73-81.
32. Ramos HC, Rumbo M & Sirard J-C (2004) Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Trends Microbiol 12: 509-517.
33. Rupnik M, Wilcox MH & Gerding DN (2009) Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 7: 526-536.
34. Ryan A, Lynch M, Smith SM et al. (2011) A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 7: e1002076.
35. Sánchez-Hurtado K, Corretge M, Mutlu E, McIlhagger R, Starr JM & Poxton IR (2008) Systemic antibody response to Clostridium difficile in colonized patients with and without symptoms and matched controls. J Med Microbiol 57: 717-724.
36. Savidge TC, Pan W-H, Newman P, O'brien M, Anton PM & Pothoulakis C (2003) Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology 125: 413-420.
37. Schwende H, Fitzke E, Ambs P & Dieter P (1996) Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1, 25-dihydroxyvitamin D3. J Leukoc Biol 59: 555-561.
38. Spigaglia P, Galeotti C & Barbanti F (2011) The LMW surface-layer proteins of Clostridium difficile PCR ribotypes 027 and 001 share common immunogenic properties. J Med Microbiol 60: 1168-1173.
39. Tasteyre A, Barc MC, Collignon A, Boureau H & Karjalainen T (2001) Role of FliC and FliD flagellar proteins of Clostridium difficile in adherence and gut colonization. Infect Immun 69: 7937-7940.
40. Viswanathan V, Sharma R & Hecht G (2004) Microbes and their products-physiological effects upon mammalian mucosa. Adv Drug Deliv Rev 56: 727-762.
41. Vohra P & Poxton IR (2011) Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile. Microbiology 157: 1343-1353.
42. Waligora AJ, Hennequin C, Mullany P, Bourlioux P, Collignon A & Karjalainen T (2001) Characterization of a cell surface protein of Clostridium difficile with adhesive properties. Infect Immun 69: 2144-2153.
43. Wright A, Wait R, Begum S, Crossett B, Nagy J, Brown K & Fairweather N (2005) Proteomic analysis of cell surface proteins from Clostridium difficile. Proteomics 5: 2443-2452.
44. Wright A, Drudy D, Kyne L, Brown K & Fairweather NF (2008) Immunoreactive cell wall proteins of Clostridium difficile identified by human sera. J Med Microbiol 57: 750-756.
45. Zügel U & Kaufmann SH (1999) Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 12: 19-39.