Rapid-access, high-throughput synchrotron crystallography for drug discovery

Trends in Pharmacological Sciences

Volumn 33, Issue 5, 2012, Pages 261-267

  Wasserman, Stephen R ^a   Koss, John W ^a   Sojitra, Sonal T ^a   Morisco, Laura L ^a   Burley, Stephen K ^b  

^a ARGONNE NATIONAL LABORATORY   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE; MEMBRANE PROTEIN;

AUTOMATION; COMPUTER PROGRAM; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; PRIORITY JOURNAL; RADIATION BEAM; REVIEW; ROBOTICS; SYNCHROTRON RADIATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; PROTEINS; SYNCHROTRONS;

EID: 84860527565     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.03.009     Document Type: Review

References (40)

1. B. Munos Lessons from 60 years of pharmaceutical innovation Nat. Rev. Drug Discov. 8 2009 959 968
2. I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 715 (Pubitemid 39173511)
3. T.L. Blundell High-throughput crystallography for lead discovery in drug design Nat. Rev. Drug Discov. 1 2002 45 54 (Pubitemid 37361403)
4. M. Congreve Structural biology and drug discovery Drug Discov. Today 10 2005 895 907
5. G. Scapin Structural biology and drug discovery Curr. Pharm. Des. 12 2006 2087 2097 (Pubitemid 43891405)
6. S.R. Wasserman High-throughput crystallographic data collection at synchrotrons M.R. Sanderson, J.V. Skelly, Macromolecular Crystallography: Conventional and High-Throughput Methods 2007 Oxford University Press 173 189
7. H. Winick Synchrotron radiation Sci. Am. 257 1987 88 99
8. P. Willmott An Introduction to Synchrotron Radiation 2011 John Wiley & Sons
9. A. Joachimiak High-throughput crystallography for structural genomics Curr. Opin. Struct. Biol. 19 2009 573 584
10. W.A. Hendrickson Determination of macromolecular structures from anomalous diffraction of synchrotron radiation Science 254 1991 51 58 (Pubitemid 21917315)
11. W.A. Hendrickson Synchrotron crystallography Trends Biochem. Sci. 25 2000 637 643
12. W. Huber, and F. Mueller Biomolecular interaction analysis in drug discovery using surface plasmon resonance technology Curr. Pharm. Des. 12 2006 3999 4021 (Pubitemid 44669759)
13. J. Ohana CATS: a cryogenic automated transfer system installed on the beamline FIP at ESRF J. Appl. Crystallogr. 37 2004 72 77
14. F. Cipriani Automation of sample mounting for macromolecular crystallograhy Acta Crystallogr. D62 2006 1251 1259 (Pubitemid 44526217)
15. J.W. Pflugrath The finer things in X-ray diffraction data collection Acta Crystallogr. D55 1999 1718 1725 (Pubitemid 29504426)
16. A.G.W. Leslie, and H.R. Powell Processing diffraction data with Mosflm R.J. Read, J.L. Sussman, Evolving Methods for Macromolecular Crystallography 2007 Springer 41 51
17. K.S. Paithankar, and E.F. Garman Know your dose: RADDOSE Acta Crystallogr. D66 2010 381 388
18. W. Kabsch XDS. Acta Crystallogr. D66 2010 125 132
19. Otwinowski, Z. and Minor, W. (1997) Processing of X-ray diffraction data collected in oscillation mode. In Methods in Enzymology. vol. 276. Macromolecular Crystallography, Part A (Carter, C.W., Jr and Sweet, R.M., eds), pp. 307-326, Academic Press (Pubitemid 27085611)
20. A.J. Sharff High throughput crystallography on an in-house source, using Actor Rigaku J. 19-20 2003 5 10
21. T.L. Blundell, and S. Patel High-throughput X-ray crystallography for drug discovery Curr. Opin. Pharmacol. 4 2004 490 496 (Pubitemid 40533010)
22. J. Blaney Fragment-based lead discovery and optimization using x-ray crystallography, computational chemistry and high-throughput organic synthesis W. Jahnke, D.A. Erlanson, Fragment-based Approaches in Drug Discovery 2006 Wiley-VCH Verlag 215 248
23. J.E. Brownell Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ Mol. Cell 37 2010 102 111
24. M.-S. Kim Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling Proc. Natl. Acad. Sci. U.S.A. 108 2011 13112 13117
25. F. Jiang Structural basis of RNA recognition and activation by innate immune receptor RIG-I Nature 479 2011 423 427
26. D.J. Marcotte Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases Protein Sci. 19 2010 429 439
27. J.A. Salon The significance of G protein-coupled receptor crystallography for drug discovery Pharmacol. Rev. 63 2011 901 937
28. C. Nave, and M.A. Hill Will reduced radiation damage occur with very small crystals? J. Synchrotron Radiat. 12 2005 299 303 (Pubitemid 41557607)
29. R.F. Fischetti Mini-beam collimator enables microcrystallography experiments on standard beamlines J. Synchrotron Radiat. 16 2009 217 225
30. S. Cusack Small is beautiful: protein micro-crystallography Nat. Struct. Biol. 5 1998 634 637 (Pubitemid 28363642)
31. R. Moukhametzianov Protein crystallography with a micrometre-sized synchrotron radiation beam Acta Crystallogr. D64 2008 158 166 (Pubitemid 351161591)
32. K. Hirata New microbeam beamline at SPring-8, targeting at protein micro-crystallography AIP Conf. Proc. 1234 2010 901 904
33. M. Caffrey Crystallizing membrane proteins for structure determination: use of lipidic mesophases Annu. Rev. Biophys. 38 2009 29 51
34. V. Cherezov Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 μm size X-ray synchrotron beam J. R. Soc. Interface 6 2009 S587 S597
35. D.J. Kissick Second-order nonlinear optical imaging of chiral crystals Annu. Rev. Anal. Chem. 4 2011 419 437
36. C. Broennimann The PILATUS 1 M detector J. Synchrotron Radiat. 13 2006 120 130
37. G. Hulsen Protein crystallography with a novel large-area pixel detector J. Appl. Crystallogr. 39 2006 550 557 (Pubitemid 44125586)
38. J. Marchal Synchrotron applications of pixel and strip detectors at Diamond Light Source Nucl. Instrum. Methods Phys. Res. A 604 2009 123 126
39. M.G. Rossman, and J.W. Erickson Oscillation photography of radiation-sensitive crystals using a synchrotron source J. Appl. Crystallogr. 16 1983 629 636
40. P.C. May Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor J. Neurosci. 16 2011 16507 16516