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Volumn 59, Issue 2, 2012, Pages 329-344

Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes

Author keywords

Cytokine storm; Hemophagocytic lymphohistiocytosis; Macrophage activation syndrome; Sepsis

Indexed keywords

ALLERGEN; CORTICOSTEROID; CYCLOSPORIN; ETOPOSIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

EID: 84860522672     PISSN: 00313955     EISSN: 15578240     Source Type: Journal    
DOI: 10.1016/j.pcl.2012.03.002     Document Type: Review
Times cited : (127)

References (55)
  • 1
    • 0026874127 scopus 로고
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20(6):864-874.
    • (1992) Crit Care Med , vol.20 , Issue.6 , pp. 864-874
  • 2
    • 21644438082 scopus 로고    scopus 로고
    • International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics
    • Goldstein B., Giroir B., Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005, 6(1):2-8.
    • (2005) Pediatr Crit Care Med , vol.6 , Issue.1 , pp. 2-8
    • Goldstein, B.1    Giroir, B.2    Randolph, A.3
  • 3
    • 33845619137 scopus 로고    scopus 로고
    • HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
    • Henter J.I., Horne A., Arico M., et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007, 48(2):124-131.
    • (2007) Pediatr Blood Cancer , vol.48 , Issue.2 , pp. 124-131
    • Henter, J.I.1    Horne, A.2    Arico, M.3
  • 4
    • 34248666067 scopus 로고    scopus 로고
    • Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    • Behrens E.M., Beukelman T., Paessler M., et al. Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis. J Rheumatol 2007, 34(5):1133-1138.
    • (2007) J Rheumatol , vol.34 , Issue.5 , pp. 1133-1138
    • Behrens, E.M.1    Beukelman, T.2    Paessler, M.3
  • 5
    • 33646776086 scopus 로고    scopus 로고
    • Peripheral hemophagocytosis: an early indicator of advanced systemic inflammatory response syndrome/hemophagocytic syndrome
    • Kuwata K., Yamada S., Kinuwaki E., et al. Peripheral hemophagocytosis: an early indicator of advanced systemic inflammatory response syndrome/hemophagocytic syndrome. Shock 2006, 25(4):344-350.
    • (2006) Shock , vol.25 , Issue.4 , pp. 344-350
    • Kuwata, K.1    Yamada, S.2    Kinuwaki, E.3
  • 6
    • 85028115490 scopus 로고    scopus 로고
    • Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT
    • Imahashi N., Inamoto Y., Ito M., et al. Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT. Bone Marrow Transplant 2011, 47(3):387-394.
    • (2011) Bone Marrow Transplant , vol.47 , Issue.3 , pp. 387-394
    • Imahashi, N.1    Inamoto, Y.2    Ito, M.3
  • 7
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006, 6(11):823-835.
    • (2006) Nat Rev Immunol , vol.6 , Issue.11 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 8
    • 84860503664 scopus 로고    scopus 로고
    • Immunodeficiency Search. 2011. Available at: . Accessed November 1
    • Jyonouchi S. Immunodeficiency Search. 2011. Available at: . Accessed November 1, 2011. http://www.immunodeficiencysearch.com.
    • (2011)
    • Jyonouchi, S.1
  • 9
    • 77951676108 scopus 로고    scopus 로고
    • Inherited defects in lymphocyte cytotoxic activity
    • Pachlopnik Schmid J., Cote M., Menager M.M., et al. Inherited defects in lymphocyte cytotoxic activity. Immunol Rev 2010, 235(1):10-23.
    • (2010) Immunol Rev , vol.235 , Issue.1 , pp. 10-23
    • Pachlopnik Schmid, J.1    Cote, M.2    Menager, M.M.3
  • 10
    • 3242752040 scopus 로고    scopus 로고
    • An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder
    • Jordan M.B., Hildeman D., Kappler J., et al. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 2004, 104(3):735-743.
    • (2004) Blood , vol.104 , Issue.3 , pp. 735-743
    • Jordan, M.B.1    Hildeman, D.2    Kappler, J.3
  • 11
    • 79960714121 scopus 로고    scopus 로고
    • Perforin is a critical physiologic regulator of T-cell activation
    • Lykens J.E., Terrell C.E., Zoller E.E., et al. Perforin is a critical physiologic regulator of T-cell activation. Blood 2011, 118(3):618-626.
    • (2011) Blood , vol.118 , Issue.3 , pp. 618-626
    • Lykens, J.E.1    Terrell, C.E.2    Zoller, E.E.3
  • 12
    • 34247353624 scopus 로고    scopus 로고
    • Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
    • Crozat K., Hoebe K., Ugolini S., et al. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 2007, 204(4):853-863.
    • (2007) J Exp Med , vol.204 , Issue.4 , pp. 853-863
    • Crozat, K.1    Hoebe, K.2    Ugolini, S.3
  • 13
    • 79959242566 scopus 로고    scopus 로고
    • Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    • Krebs P., Crozat K., Popkin D., et al. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood 2011, 117(24):6582-6588.
    • (2011) Blood , vol.117 , Issue.24 , pp. 6582-6588
    • Krebs, P.1    Crozat, K.2    Popkin, D.3
  • 14
    • 79954599747 scopus 로고    scopus 로고
    • Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
    • Sumegi J., Barnes M.G., Nestheide S.V., et al. Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis. Blood 2011, 117(15):e151-e160.
    • (2011) Blood , vol.117 , Issue.15
    • Sumegi, J.1    Barnes, M.G.2    Nestheide, S.V.3
  • 15
    • 79551644967 scopus 로고    scopus 로고
    • Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
    • Pachlopnik Schmid J., Canioni D., Moshous D., et al. Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency). Blood 2011, 117(5):1522-1529.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1522-1529
    • Pachlopnik Schmid, J.1    Canioni, D.2    Moshous, D.3
  • 16
    • 0036900751 scopus 로고    scopus 로고
    • Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    • Imashuku S. Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Crit Rev Oncol Hematol 2002, 44(3):259-272.
    • (2002) Crit Rev Oncol Hematol , vol.44 , Issue.3 , pp. 259-272
    • Imashuku, S.1
  • 17
    • 68849131525 scopus 로고    scopus 로고
    • Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation
    • Castillo L., Carcillo J. Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med 2009, 10(3):387-392.
    • (2009) Pediatr Crit Care Med , vol.10 , Issue.3 , pp. 387-392
    • Castillo, L.1    Carcillo, J.2
  • 18
    • 33646841830 scopus 로고    scopus 로고
    • Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood
    • Avcin T., Tse S.M., Schneider R., et al. Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood. J Pediatr 2006, 148(5):683-686.
    • (2006) J Pediatr , vol.148 , Issue.5 , pp. 683-686
    • Avcin, T.1    Tse, S.M.2    Schneider, R.3
  • 19
    • 0035511981 scopus 로고    scopus 로고
    • Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders
    • Sawhney S., Woo P., Murray K.J. Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders. Arch Dis Child 2001, 85(5):421-426.
    • (2001) Arch Dis Child , vol.85 , Issue.5 , pp. 421-426
    • Sawhney, S.1    Woo, P.2    Murray, K.J.3
  • 20
    • 79953219478 scopus 로고    scopus 로고
    • Genetic and molecular basis of inflammasome-mediated disease
    • Hoffman H.M., Brydges S.D. Genetic and molecular basis of inflammasome-mediated disease. J Biol Chem 2011, 286(13):10889-10896.
    • (2011) J Biol Chem , vol.286 , Issue.13 , pp. 10889-10896
    • Hoffman, H.M.1    Brydges, S.D.2
  • 21
    • 0037338925 scopus 로고    scopus 로고
    • Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • Grom A.A., Villanueva J., Lee S., et al. Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr 2003, 142(3):292-296.
    • (2003) J Pediatr , vol.142 , Issue.3 , pp. 292-296
    • Grom, A.A.1    Villanueva, J.2    Lee, S.3
  • 22
    • 21744452702 scopus 로고    scopus 로고
    • Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • Villanueva J., Lee S., Giannini E.H., et al. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther 2005, 7(1):R30-R37.
    • (2005) Arthritis Res Ther , vol.7 , Issue.1
    • Villanueva, J.1    Lee, S.2    Giannini, E.H.3
  • 23
    • 77950531755 scopus 로고    scopus 로고
    • Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
    • Vastert S.J., van Wijk R., D'Urbano L.E., et al. Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 2010, 49(3):441-449.
    • (2010) Rheumatology (Oxford) , vol.49 , Issue.3 , pp. 441-449
    • Vastert, S.J.1    van Wijk, R.2    D'Urbano, L.E.3
  • 24
    • 49749127387 scopus 로고    scopus 로고
    • Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    • Zhang K., Biroschak J., Glass D.N., et al. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Arthritis Rheum 2008, 58(9):2892-2896.
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2892-2896
    • Zhang, K.1    Biroschak, J.2    Glass, D.N.3
  • 25
    • 36049020585 scopus 로고    scopus 로고
    • Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    • Fall N., Barnes M., Thornton S., et al. Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum 2007, 56(11):3793-3804.
    • (2007) Arthritis Rheum , vol.56 , Issue.11 , pp. 3793-3804
    • Fall, N.1    Barnes, M.2    Thornton, S.3
  • 26
    • 79953301748 scopus 로고    scopus 로고
    • Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis
    • Yanagimachi M., Naruto T., Miyamae T., et al. Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis. J Rheumatol 2011, 38(4):769-774.
    • (2011) J Rheumatol , vol.38 , Issue.4 , pp. 769-774
    • Yanagimachi, M.1    Naruto, T.2    Miyamae, T.3
  • 27
    • 79957889288 scopus 로고    scopus 로고
    • Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
    • Behrens E.M., Canna S.W., Slade K., et al. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 2011, 121(6):2264-2277.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2264-2277
    • Behrens, E.M.1    Canna, S.W.2    Slade, K.3
  • 28
    • 40449107086 scopus 로고    scopus 로고
    • TLR9 contributes to antiviral immunity during gammaherpesvirus infection
    • Guggemoos S., Hangel D., Hamm S., et al. TLR9 contributes to antiviral immunity during gammaherpesvirus infection. J Immunol 2008, 180(1):438-443.
    • (2008) J Immunol , vol.180 , Issue.1 , pp. 438-443
    • Guggemoos, S.1    Hangel, D.2    Hamm, S.3
  • 29
    • 71649101226 scopus 로고    scopus 로고
    • Emerging roles of TLR7 and TLR9 in murine SLE
    • Santiago-Raber M.L., Baudino L., Izui S. Emerging roles of TLR7 and TLR9 in murine SLE. J Autoimmun 2009, 33(3-4):231-238.
    • (2009) J Autoimmun , vol.33 , Issue.3-4 , pp. 231-238
    • Santiago-Raber, M.L.1    Baudino, L.2    Izui, S.3
  • 30
    • 34547216848 scopus 로고    scopus 로고
    • Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
    • Fife M.S., Gutierrez A., Ogilvie E.M., et al. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res Ther 2006, 8(5):R148.
    • (2006) Arthritis Res Ther , vol.8 , Issue.5
    • Fife, M.S.1    Gutierrez, A.2    Ogilvie, E.M.3
  • 31
    • 79952652977 scopus 로고    scopus 로고
    • IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA)
    • Moller J.C., Paul D., Ganser G., et al. IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). Clin Exp Rheumatol 2010, 28(6):912-918.
    • (2010) Clin Exp Rheumatol , vol.28 , Issue.6 , pp. 912-918
    • Moller, J.C.1    Paul, D.2    Ganser, G.3
  • 32
    • 77951822160 scopus 로고    scopus 로고
    • Cytokine profiles of macrophage activation syndrome associated with rheumatic diseases
    • Maruyama J., Inokuma S. Cytokine profiles of macrophage activation syndrome associated with rheumatic diseases. J Rheumatol 2010, 37(5):967-973.
    • (2010) J Rheumatol , vol.37 , Issue.5 , pp. 967-973
    • Maruyama, J.1    Inokuma, S.2
  • 33
    • 77955751173 scopus 로고    scopus 로고
    • Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
    • Shimizu M., Yokoyama T., Yamada K., et al. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Rheumatology 2010, 49(9):1645-1653.
    • (2010) Rheumatology , vol.49 , Issue.9 , pp. 1645-1653
    • Shimizu, M.1    Yokoyama, T.2    Yamada, K.3
  • 34
    • 0031926347 scopus 로고    scopus 로고
    • Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis
    • Janka G., Imashuku S., Elinder G., et al. Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am 1998, 12(2):435-444.
    • (1998) Hematol Oncol Clin North Am , vol.12 , Issue.2 , pp. 435-444
    • Janka, G.1    Imashuku, S.2    Elinder, G.3
  • 35
    • 77949666728 scopus 로고    scopus 로고
    • Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis
    • Brown D.E., McCoy M.W., Pilonieta M.C., et al. Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis. PLoS One 2010, 5(2):e9441.
    • (2010) PLoS One , vol.5 , Issue.2
    • Brown, D.E.1    McCoy, M.W.2    Pilonieta, M.C.3
  • 36
    • 79958292813 scopus 로고    scopus 로고
    • Hemophagocytosis causes a consumptive anemia of inflammation
    • Zoller E.E., Lykens J.E., Terrell C.E., et al. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 2011, 208(6):1203-1214.
    • (2011) J Exp Med , vol.208 , Issue.6 , pp. 1203-1214
    • Zoller, E.E.1    Lykens, J.E.2    Terrell, C.E.3
  • 39
    • 0036702894 scopus 로고    scopus 로고
    • Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome
    • Veerakul G., Sanpakit K., Tanphaichitr V.S., et al. Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome. J Med Assoc Thai 2002, 85(Suppl 2):S530-S541.
    • (2002) J Med Assoc Thai , vol.85 , Issue.SUPPL. 2
    • Veerakul, G.1    Sanpakit, K.2    Tanphaichitr, V.S.3
  • 40
    • 77957736074 scopus 로고    scopus 로고
    • Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    • Milner J.D., Orekov T., Ward J.M., et al. Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood 2010, 116(14):2476-2483.
    • (2010) Blood , vol.116 , Issue.14 , pp. 2476-2483
    • Milner, J.D.1    Orekov, T.2    Ward, J.M.3
  • 41
    • 18144367693 scopus 로고    scopus 로고
    • Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
    • Ravelli A., Magni-Manzoni S., Pistorio A., et al. Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. J Pediatr 2005, 146(5):598-604.
    • (2005) J Pediatr , vol.146 , Issue.5 , pp. 598-604
    • Ravelli, A.1    Magni-Manzoni, S.2    Pistorio, A.3
  • 42
    • 79954503180 scopus 로고    scopus 로고
    • Serum neopterin levels as a diagnostic marker of hemophagocytic lymphohistiocytosis syndrome
    • Ibarra M.F., Klein-Gitelman M., Morgan E., et al. Serum neopterin levels as a diagnostic marker of hemophagocytic lymphohistiocytosis syndrome. Clin Vaccine Immunol 2011, 18(4):609-614.
    • (2011) Clin Vaccine Immunol , vol.18 , Issue.4 , pp. 609-614
    • Ibarra, M.F.1    Klein-Gitelman, M.2    Morgan, E.3
  • 43
    • 33947158702 scopus 로고    scopus 로고
    • The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    • Bleesing J., Prada A., Siegel D.M., et al. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum 2007, 56(3):965-971.
    • (2007) Arthritis Rheum , vol.56 , Issue.3 , pp. 965-971
    • Bleesing, J.1    Prada, A.2    Siegel, D.M.3
  • 44
    • 77956305107 scopus 로고    scopus 로고
    • A novel assay for investigation of suspected familial haemophagocytic lymphohistiocytosis
    • Wheeler R.D., Cale C.M., Cetica V., et al. A novel assay for investigation of suspected familial haemophagocytic lymphohistiocytosis. Br J Haematol 2010, 150(6):727-730.
    • (2010) Br J Haematol , vol.150 , Issue.6 , pp. 727-730
    • Wheeler, R.D.1    Cale, C.M.2    Cetica, V.3
  • 45
    • 79953309677 scopus 로고    scopus 로고
    • An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis
    • Davi S., Consolaro A., Guseinova D., et al. An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis. J Rheumatol 2011, 38(4):764-768.
    • (2011) J Rheumatol , vol.38 , Issue.4 , pp. 764-768
    • Davi, S.1    Consolaro, A.2    Guseinova, D.3
  • 46
    • 38349088595 scopus 로고    scopus 로고
    • TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders
    • Sun S., Rao N.L., Venable J., et al. TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets 2007, 6(4):223-235.
    • (2007) Inflamm Allergy Drug Targets , vol.6 , Issue.4 , pp. 223-235
    • Sun, S.1    Rao, N.L.2    Venable, J.3
  • 47
    • 80051601409 scopus 로고    scopus 로고
    • Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward
    • Marsh R.A., Jordan M.B., Filipovich A.H. Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward. Br J Haematol 2011, 154(5):556-563.
    • (2011) Br J Haematol , vol.154 , Issue.5 , pp. 556-563
    • Marsh, R.A.1    Jordan, M.B.2    Filipovich, A.H.3
  • 48
    • 0036786375 scopus 로고    scopus 로고
    • Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation
    • Henter J.I., Samuelsson-Horne A., Arico M., et al. Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood 2002, 100(7):2367-2373.
    • (2002) Blood , vol.100 , Issue.7 , pp. 2367-2373
    • Henter, J.I.1    Samuelsson-Horne, A.2    Arico, M.3
  • 49
    • 34548406426 scopus 로고    scopus 로고
    • Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis
    • Balamuth N.J., Nichols K.E., Paessler M., et al. Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol 2007, 29(8):569-573.
    • (2007) J Pediatr Hematol Oncol , vol.29 , Issue.8 , pp. 569-573
    • Balamuth, N.J.1    Nichols, K.E.2    Paessler, M.3
  • 50
    • 60849097890 scopus 로고    scopus 로고
    • Experience with hemophagocytic lymphohistiocytosis/macrophage activation syndrome at a single institution
    • Gupta A.A., Tyrrell P., Valani R., et al. Experience with hemophagocytic lymphohistiocytosis/macrophage activation syndrome at a single institution. J Pediatr Hematol Oncol 2009, 31(2):81-84.
    • (2009) J Pediatr Hematol Oncol , vol.31 , Issue.2 , pp. 81-84
    • Gupta, A.A.1    Tyrrell, P.2    Valani, R.3
  • 51
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3(1):23-35.
    • (2003) Nat Rev Immunol , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 52
    • 18644385243 scopus 로고    scopus 로고
    • Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    • Pascual V., Allantaz F., Arce E., et al. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005, 201(9):1479-1486.
    • (2005) J Exp Med , vol.201 , Issue.9 , pp. 1479-1486
    • Pascual, V.1    Allantaz, F.2    Arce, E.3
  • 53
    • 79551654446 scopus 로고    scopus 로고
    • Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series
    • Nigrovic P.A., Mannion M., Prince F.H., et al. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum 2011, 63(2):545-555.
    • (2011) Arthritis Rheum , vol.63 , Issue.2 , pp. 545-555
    • Nigrovic, P.A.1    Mannion, M.2    Prince, F.H.3
  • 54
    • 33749994238 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis
    • Behrens E.M., Kreiger P.A., Cherian S., et al. Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis. J Rheumatol 2006, 33(10):2081-2084.
    • (2006) J Rheumatol , vol.33 , Issue.10 , pp. 2081-2084
    • Behrens, E.M.1    Kreiger, P.A.2    Cherian, S.3
  • 55
    • 78651365935 scopus 로고    scopus 로고
    • Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids
    • Bruck N., Suttorp M., Kabus M., et al. Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids. J Clin Rheumatol 2011, 17(1):23-27.
    • (2011) J Clin Rheumatol , vol.17 , Issue.1 , pp. 23-27
    • Bruck, N.1    Suttorp, M.2    Kabus, M.3


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