Apoptosis induced by pneumolysin in human endothelial cells involves mitogen-activated protein kinase phosphorylation

International Journal of Molecular Medicine

Volumn 29, Issue 6, 2012, Pages 1025-1030

  Zhou, Aie ^a   Wang, Hong ^a   Lan, Kai ^b   Zhang, Xuemei ^a   Xu, Wenchun ^a   Yin, Yibing ^a   Li, Dairong ^a   Yuan, Jun ^a   He, Yujuan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Guangdong Province Hospital of TCM   (China)

Author keywords

Apoptosis; Caspase; Extracellular signaling regulation kinase 1 2; Human umbilical vein endothelial cells; p38 mitogen activated protein kinase; Pneumolysin

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PNEUMOLYSIN; VIRULENCE FACTOR;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HOST CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

APOPTOSIS; BACTERIAL PROTEINS; CASPASES; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; STREPTOLYSINS;

EID: 84860520426     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.946     Document Type: Article

References (19)

1. Bogaert D, De Groot R and Hermans PW: Streptococcus pneumoniae colonization: the key to pneumococcal disease. Lancet Infect Dis 4: 144-154, 2004. (Pubitemid 38293138)
2. Mitchell TJ and Andrew PW: Biological properties of pneumolysin. Microb Drug Resist 3: 19-26, 1997. (Pubitemid 27172175)
3. Paton JC, Berry AM, Lock RA, et al: Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infect Immun 54: 50-55, 1986. (Pubitemid 16021212)
4. Kanclerski K and Möllby R: Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin). J Clin Microbiol 25: 222-225, 1987. (Pubitemid 17232407)
5. Kyriakis JM and Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001. (Pubitemid 32267078)
6. Shi Y: Machanisms of caspase activation and inhibition during apoptosis. Mol Cell 9: 459-470, 2002.
7. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J: Human ICE/CED-3 protease nomenclature. Cell 87: 171, 1996.
8. N'Guessan PD, Schmeck B, Ayim A, et al: Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb Haemost 94: 295-303, 2005. (Pubitemid 41122483)
9. Colino J and Snapper CM: Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J Immunol 171: 2354-2365, 2003. (Pubitemid 37025542)
10. Braun JS, Hoffmann O, Schickhaus M, et al: Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun 75: 4245-4254, 2007. (Pubitemid 47378080)
11. Beurg M, Hafidi A, Skinner L, et al: The mechanism of pneumolysin-induced cochlear hair. J Physiol 568: 211-227, 2005.
12. Schmeck B, Gross R, N'Guessan PD, Hocke AC, Hammerschmidt S, Mitchell TJ, Rosseau S, Suttorp N and Hippenstiel S: Streptococcus pneumoniae induced caspase 6 dependent apoptosis in lung epithelium. Infect Immun 72: 4940-4947, 2004. (Pubitemid 39223376)
13. Kirkham LA, Kerr AR, Douce GR, Paterson GK, Dilts DA, Liu DF and Mitchell TJ: Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines. Infect Immun 74: 586-593, 2006. (Pubitemid 43023114)
14. Engelich G, White M and Hartshorn KL: Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst. J Leukoc Biol 69: 50-56, 2001. (Pubitemid 32095116)
15. Csortos C, Kolosova I and Verin AD: Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family. Am J Physiol Lung Cell Mol Physiol 293: L843-L854, 2007. (Pubitemid 47572232)
16. Osborn L: Leukocyte adhesion to endothelium in inflammation. Cell 62: 3-6, 1990.
17. Hahne M, Jager U, Isenmann S, Hallmann R and Vestweber D: Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J Cell Biol 121: 655-664, 1993. (Pubitemid 23131276)
18. Zysk G, Schneider-Wald BK, Hwang JH et al: Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infect Immun 69: 845-852, 2001. (Pubitemid 32109548)
19. Niyonsaba F, Ushio H, Nagaoka I, Okumura K and Ogawa H: The human beta-defesins (-1, -2, -3, -4) and cathlicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes. J Immunol 175: 1776-1784, 2005. (Pubitemid 41023082)