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Volumn 7, Issue 1, 2012, Pages 30-35

Novel asthma therapies: A review

Author keywords

Anti Inflammatory Medications; Asthma; Immunotherapy; Inhaled Bronchodilators; Inhaled Corticosteroids; Monoclonal Antibody

Indexed keywords

ANTIASTHMATIC AGENT; BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BENRALIZUMAB; BUDESONIDE; BUDESONIDE PLUS FORMOTEROL; CARMOTEROL; CICLESONIDE; ENOKIZUMAB; ETANERCEPT; FLUTICASONE; FLUTICASONE PROPIONATE PLUS FORMOTEROL FUMARATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; FLUTIFORM; FORMOTEROL; FORMOTEROL FUMARATE PLUS MOMETASONE FUMARATE; FORMOTEROL FUMARATE PLUS MOMETASONE FUROATE; INDACATEROL; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; MONOCLONAL ANTIBODY; OGLEMILAST; PLACEBO; RESLIZUMAB; ROFLUMILAST; TOFIMILAST; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG;

EID: 84860516160     PISSN: 15748855     EISSN: 10657630     Source Type: Journal    
DOI: 10.2174/157488512800389182     Document Type: Review
Times cited : (2)

References (52)
  • 2
    • 77957154681 scopus 로고    scopus 로고
    • National Institute of Health, August 27
    • National Asthma Guidelines Updated. National Institute of Health. http://www.nih.gov/news/pr/aug2007/nhbli-29.htm. August 27, 2007.
    • (2007) National Asthma Guidelines Updated
  • 5
    • 84860542389 scopus 로고    scopus 로고
    • Bronchial Asthma Up-To-Date: Repair and Remodeling of Bronchial Mucosa
    • Shunsuke S. Bronchial Asthma Up-To-Date: Repair and Remodeling of Bronchial Mucosa. Jap J Natl Med Services 1999; 53: 239-245.
    • (1999) Jap J Natl Med Services , vol.53 , pp. 239-245
    • Shunsuke, S.1
  • 7
    • 0037103337 scopus 로고    scopus 로고
    • Key Role for Mast Cells in Nonatopic Asthma
    • Kraneveld AD, Hanneke PM, Mirjam K, et al. Key Role for Mast Cells in Nonatopic Asthma. J Immunol 2002; 169: 2044-2053.
    • (2002) J Immunol , vol.169 , pp. 2044-2053
    • Kraneveld, A.D.1    Hanneke, P.M.2    Mirjam, K.3
  • 9
    • 0026529253 scopus 로고
    • Beta-2 adrenergic receptors in asthma: A current perspective
    • Bai, TR. Beta-2 adrenergic receptors in asthma: A current perspective. Lung 1992; 170: 125-141.
    • (1992) Lung , vol.170 , pp. 125-141
    • Bai, T.R.1
  • 10
    • 37349020090 scopus 로고    scopus 로고
    • Tolerability of indacaterol, a novel once-daily beta2-agonist, in patients with asthma: A randomized, placebo-controlled, 28-day safety study
    • Yang WH, Martinot JB, Pohunek P, et al. Tolerability of indacaterol, a novel once-daily beta2-agonist, in patients with asthma: a randomized, placebo-controlled, 28-day safety study. Ann Allergy Asthma Immunol 2007; 99: 555-561.
    • (2007) Ann Allergy Asthma Immunol , vol.99 , pp. 555-561
    • Yang, W.H.1    Martinot, J.B.2    Pohunek, P.3
  • 11
    • 36649002044 scopus 로고    scopus 로고
    • Indacaterol provides sustained 24 h bronchodilation on once-daily dosing in asthma: A 7-day dose-ranging study
    • LaForce C, Alexander M, Deckelmann R, et al. Indacaterol provides sustained 24 h bronchodilation on once-daily dosing in asthma: a 7-day dose-ranging study. Allergy 2008; 63: 103-111.
    • (2008) Allergy , vol.63 , pp. 103-111
    • Laforce, C.1    Alexander, M.2    Deckelmann, R.3
  • 12
    • 34248228623 scopus 로고    scopus 로고
    • Indacaterol, a novel inhaled beta2-agonist, provides sustained 24-h bronchodilation in asthma
    • Beeh KM, Derom E, Kanniess F, et al. Indacaterol, a novel inhaled beta2-agonist, provides sustained 24-h bronchodilation in asthma. Eur Respir J 2007: 29: 871-878.
    • (2007) Eur Respir J , vol.29 , pp. 871-878
    • Beeh, K.M.1    Derom, E.2    Kanniess, F.3
  • 13
    • 77957115277 scopus 로고    scopus 로고
    • 24-h bronchodilator efficacy of single doses of indacaterol in Japanese patients with asthma: A comparison with placebo and salmeterol
    • Sugihara N, Kanada S, Haida M, et al. 24-h bronchodilator efficacy of single doses of indacaterol in Japanese patients with asthma: a comparison with placebo and salmeterol. Respir Med 2010; 104: 1629-1637.
    • (2010) Respir Med , vol.104 , pp. 1629-1637
    • Sugihara, N.1    Kanada, S.2    Haida, M.3
  • 14
    • 57749189082 scopus 로고    scopus 로고
    • Efficacy and safety of indacaterol, a new 24-hour beta2-agonist, in patients with asthma: A dose-ranging study
    • Kanniess F, Boulet LP, Pierzhala W, et al. Efficacy and safety of indacaterol, a new 24-hour beta2-agonist, in patients with asthma: a dose-ranging study. J Asthma 2008; 45: 887-92.
    • (2008) J Asthma , vol.45 , pp. 887-892
    • Kanniess, F.1    Boulet, L.P.2    Pierzhala, W.3
  • 15
    • 47349093973 scopus 로고    scopus 로고
    • Bronchodilator efficacy of indacaterol, a novel once-daily beta2-agonist in patients with persistent asthma
    • Pearlman DS, Greos L, LaForce C, et al. Bronchodilator efficacy of indacaterol, a novel once-daily beta2-agonist in patients with persistent asthma. Ann Allergy Asthma Immunol 2008; 101: 90-95.
    • (2008) Ann Allergy Asthma Immunol , vol.101 , pp. 90-95
    • Pearlman, D.S.1    Greos, L.2    Laforce, C.3
  • 16
    • 46149095401 scopus 로고    scopus 로고
    • Efficacy of the novel very long-acting beta-2 agonist carmoterol following 7 days once daily dosing: Comparison with twice daily formoterol in patients with persistent asthma
    • Poster 3858
    • Kottakis I, Nandeuil A, Raptis H, et al. Efficacy of the novel very long-acting beta-2 agonist carmoterol following 7 days once daily dosing: comparison with twice daily formoterol in patients with persistent asthma. Eur Respir J Suppl 2006. Poster 3858.
    • (2006) Eur Respir J Suppl
    • Kottakis, I.1    Nandeuil, A.2    Raptis, H.3
  • 17
    • 33745475106 scopus 로고    scopus 로고
    • Ciclesonide for the treatment of asthma
    • Dahl R. Ciclesonide for the treatment of asthma. Ther Clin Risk Manag 2006; 2: 25-38.
    • (2006) Ther Clin Risk Manag , vol.2 , pp. 25-38
    • Dahl, R.1
  • 18
    • 34250753801 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily inhaled ciclesonide in adults with mild to moderate asthma: A double-blind, placebo-controlled study
    • Adachi M, Ishihara K, Inoue H, et al. Efficacy and safety of once-daily inhaled ciclesonide in adults with mild to moderate asthma: a double-blind, placebo-controlled study. Respirology 2007; 12: 566-572.
    • (2007) Respirology , vol.12 , pp. 566-572
    • Adachi, M.1    Ishihara, K.2    Inoue, H.3
  • 19
    • 20444468843 scopus 로고    scopus 로고
    • Ciclesonide, A novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma
    • Szefler S, Shashank R, James W, et al. Ciclesonide, A novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma. Chest 2005; 128: 1104-1114.
    • (2005) Chest , vol.128 , pp. 1104-1114
    • Szefler, S.1    Shashank, R.2    James, W.3
  • 20
    • 34447573041 scopus 로고    scopus 로고
    • Ciclesonide is more effective than budesonide in the treatment of persistent asthma
    • Ukena D, Biberger C, Steinijans V, et al. Ciclesonide is more effective than budesonide in the treatment of persistent asthma. Pulm Pharmacol & Ther 2007; 20: 562-570.
    • (2007) Pulm Pharmacol & Ther , vol.20 , pp. 562-570
    • Ukena, D.1    Biberger, C.2    Steinijans, V.3
  • 21
    • 34250670081 scopus 로고    scopus 로고
    • A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma
    • Boulet LP, Bateman ED, Voves R, et al. A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respir Med 2007; 101: 1677-1686.
    • (2007) Respir Med , vol.101 , pp. 1677-1686
    • Boulet, L.P.1    Bateman, E.D.2    Voves, R.3
  • 22
    • 33747156391 scopus 로고    scopus 로고
    • Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma
    • Buhl R, Vinkler I, Magyar P, et al. Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma. Pulm Pharmacol & Ther J 2006; 19: 404-412.
    • (2006) Pulm Pharmacol & Ther J , vol.19 , pp. 404-412
    • Buhl, R.1    Vinkler, I.2    Magyar, P.3
  • 23
    • 45149093130 scopus 로고    scopus 로고
    • Ciclesonide versus other inhaled steroids for chronic asthma in children and adults
    • Manning P, Gibson PG, Lasserson TJ. Ciclesonide versus other inhaled steroids for chronic asthma in children and adults. Cochrane Database Syst Rev 2008; 2.
    • (2008) Cochrane Database Syst Rev , pp. 2
    • Manning, P.1    Gibson, P.G.2    Lasserson, T.J.3
  • 24
    • 23244466134 scopus 로고    scopus 로고
    • Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma
    • Gauvreau GM, Boulet LP, Postma DS, et al. Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma. J Allergy Clinl Immunol 2005; 116: 285-291.
    • (2005) J Allergy Clinl Immunol , vol.116 , pp. 285-291
    • Gauvreau, G.M.1    Boulet, L.P.2    Postma, D.S.3
  • 25
    • 38349163137 scopus 로고    scopus 로고
    • Effect of Ciclesonide Treatment on Allergen-Induced Changes in T Cell Regulation in Asthma
    • Heijink I, Kauffman H, Vellenga E, et al. Effect of Ciclesonide Treatment on Allergen-Induced Changes in T Cell Regulation in Asthma. Intl Arch Allergy Immunol 2008; 145: 111-121.
    • (2008) Intl Arch Allergy Immunol , vol.145 , pp. 111-121
    • Heijink, I.1    Kauffman, H.2    Vellenga, E.3
  • 26
    • 77953635199 scopus 로고    scopus 로고
    • Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children
    • Ducharme FM, NiChroinin M, Greenstone I, et al. Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database Syst Rev 2010; 5:CD005535.
    • (2010) Cochrane Database Syst Rev , vol.5
    • Ducharme, F.M.1    Nichroinin, M.2    Greenstone, I.3
  • 27
    • 78650510479 scopus 로고    scopus 로고
    • The addition of long-acting beta-agonists to inhaled corticosteroids in asthma
    • Sears MR. The addition of long-acting beta-agonists to inhaled corticosteroids in asthma. Curr Opin Pulm Med 2011; 17: 23-28.
    • (2011) Curr Opin Pulm Med , vol.17 , pp. 23-28
    • Sears, M.R.1
  • 28
    • 79953026455 scopus 로고    scopus 로고
    • Efficacy and safety of fluticssone and formoterol in a single pressurized metered dose inhaler
    • Bodzenta-Lukaszk A, Pulka G, Dymek A, et al. Efficacy and safety of fluticssone and formoterol in a single pressurized metered dose inhaler. Respir Med 2011; 105: 674-682.
    • (2011) Respir Med , vol.105 , pp. 674-682
    • Bodzenta-Lukaszk, A.1    Pulka, G.2    Dymek, A.3
  • 29
    • 79956205897 scopus 로고    scopus 로고
    • Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: An open-label, randomized study
    • Bodzenta-Lukaszk A, Dymek A, McAulay K, et al. Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study. BMC Pulm Med 2011; 11: 28.
    • (2011) BMC Pulm Med , vol.11 , pp. 28
    • Bodzenta-Lukaszk, A.1    Dymek, A.2    McAulay, K.3
  • 30
    • 77953090892 scopus 로고    scopus 로고
    • Effects of extra-fine beclomethasone/formoterol on both large and small airways in asthma
    • Scichilone N, Battaglia S, Sorino C, et al. Effects of extra-fine beclomethasone/formoterol on both large and small airways in asthma. Allergy 2010; 65: 897-902.
    • (2010) Allergy , vol.65 , pp. 897-902
    • Scichilone, N.1    Battaglia, S.2    Sorino, C.3
  • 31
    • 34548484562 scopus 로고    scopus 로고
    • Beclomethasone/formoterol vs. fluticasone/salmeterol inhaled combination in moderate to severe asthma
    • Papi A, Paggiaro P, Nicolini G, et al. Beclomethasone/formoterol vs. fluticasone/salmeterol inhaled combination in moderate to severe asthma. Allergy 2007; 62: 1182-1188.
    • (2007) Allergy , vol.62 , pp. 1182-1188
    • Papi, A.1    Paggiaro, P.2    Nicolini, G.3
  • 32
    • 34147160761 scopus 로고    scopus 로고
    • Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma
    • Papi A, Paggiaro PL, Nicolilni G, et al. Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma. Eur Respir J 2007; 29: 682-689.
    • (2007) Eur Respir J , vol.29 , pp. 682-689
    • Papi, A.1    Paggiaro, P.L.2    Nicolilni, G.3
  • 33
    • 79960906296 scopus 로고    scopus 로고
    • Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: Dual-selective phosphodiesterase inhibitors and novel combination therapies
    • Giembycz MA, Newton R. Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase inhibitors and novel combination therapies. Handbook Exp Pharmacol 2011; 204: 415-446.
    • (2011) Handbook Exp Pharmacol , vol.204 , pp. 415-446
    • Giembycz, M.A.1    Newton, R.2
  • 34
    • 34447623738 scopus 로고    scopus 로고
    • Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge
    • Louw C, Williams Z, Venter L, et al. Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge. Respiration 2007; 74: 411-417.
    • (2007) Respiration , vol.74 , pp. 411-417
    • Louw, C.1    Williams, Z.2    Venter, L.3
  • 35
    • 23244467556 scopus 로고    scopus 로고
    • Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions
    • Van Schalkwyk E, Strydom K, Williams Z, et al. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol 2005; 116: 292-298.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 292-298
    • van Schalkwyk, E.1    Strydom, K.2    Williams, Z.3
  • 37
    • 33644904643 scopus 로고    scopus 로고
    • Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma
    • Bousquet J, Aubier M, Sastre J, et al. Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma. Allergy 2006; 61: 72-78.
    • (2006) Allergy , vol.61 , pp. 72-78
    • Bousquet, J.1    Aubier, M.2    Sastre, J.3
  • 38
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176: 1062-1071.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 39
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. New Eng J Med 2009; 360: 973-984.
    • (2009) New Eng J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 40
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. New Eng J Med 2009; 360: 985-993.
    • (2009) New Eng J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 41
    • 0038643527 scopus 로고    scopus 로고
    • Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips JC, O'Connor BJ, Langley SJ, et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med 2003; 167: 1655-1659.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1655-1659
    • Kips, J.C.1    O'Connor, B.J.2    Langley, S.J.3
  • 43
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmocokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma
    • e2
    • Busse WW, Katial R, Gossage D, et al. Safety profile, pharmocokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. JACI 2010; 125: 1237-1244.e2
    • (2010) JACI , vol.125 , pp. 1237-1244
    • Busse, W.W.1    Katial, R.2    Gossage, D.3
  • 44
    • 40049104660 scopus 로고    scopus 로고
    • A single dose of Medi-528, a monoclonal antibody against interleukin-9, is well tolerated in mild and moderate asthmatics in the phase II trial
    • O'Byrne P, Boulet LP, Gauvreau G, et al. A single dose of Medi-528, a monoclonal antibody against interleukin-9, is well tolerated in mild and moderate asthmatics in the phase II trial. CHEST: Chest Meeting Abstracts 2007; 132: 478.
    • (2007) CHEST: Chest Meeting Abstracts , vol.132 , pp. 478
    • O'Byrne, P.1    Boulet, L.P.2    Gauvreau, G.3
  • 45
    • 65549123549 scopus 로고    scopus 로고
    • Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers
    • White B, Leon F, White W, et al. Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers. Clin Ther 2009; 31: 728-740.
    • (2009) Clin Ther , vol.31 , pp. 728-740
    • White, B.1    Leon, F.2    White, W.3
  • 46
    • 79952049626 scopus 로고    scopus 로고
    • Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma
    • Parker JM, Oh CK, LaForce C, et al. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med 2011; 11: 14.
    • (2011) BMC Pulm Med , vol.11 , pp. 14
    • Parker, J.M.1    Oh, C.K.2    Laforce, C.3
  • 47
    • 34248369746 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitors for the treatment of asthma
    • Kim J, Remick DG. Tumor necrosis factor inhibitors for the treatment of asthma. Curr Allergy Asthma Reports 2007; 7: 151-156.
    • (2007) Curr Allergy Asthma Reports , vol.7 , pp. 151-156
    • Kim, J.1    Remick, D.G.2
  • 48
    • 47049130758 scopus 로고    scopus 로고
    • The role of a soluble TNF-a receptor fusion protein (Etanercept) in corticosteroid refractory asthma: A double blind, randomized placebo-controlled trial
    • Morjaria JB, Chauhan AJ, Babu KS, et al. The role of a soluble TNF-a receptor fusion protein (Etanercept) in corticosteroid refractory asthma: a double blind, randomized placebo-controlled trial. Thorax 2008; 63: 584-591.
    • (2008) Thorax , vol.63 , pp. 584-591
    • Morjaria, J.B.1    Chauhan, A.J.2    Babu, K.S.3
  • 49
    • 79957987328 scopus 로고    scopus 로고
    • Efficacy and safety of etanercept in moderate-to-severe asthma: A randomized, controlled trial
    • Holgate ST, Noonan M, Chanez P, et al. Efficacy and safety of etanercept in moderate-to-severe asthma: a randomized, controlled trial. Eur Respir J 2011; 37: 1352-1359.
    • (2011) Eur Respir J , vol.37 , pp. 1352-1359
    • Holgate, S.T.1    Noonan, M.2    Chanez, P.3
  • 50
    • 3943084864 scopus 로고    scopus 로고
    • Tuberculosis following the use of etanercept, a tumor necrosis factor inhibitor
    • Mohan AK, Cote TR, Block JA, et al. Tuberculosis following the use of etanercept, a tumor necrosis factor inhibitor. Clinl Infectious Disease 2004; 39: 295-299.
    • (2004) Clinl Infectious Disease , vol.39 , pp. 295-299
    • Mohan, A.K.1    Cote, T.R.2    Block, J.A.3
  • 51
    • 37349096305 scopus 로고    scopus 로고
    • Etanercept therapy in patients with a positive tuberculin skin test
    • Manadan, AM, Joyce K, Sequeira W, et al. Etanercept therapy in patients with a positive tuberculin skin test. Clin Exp Rheumatol 2007; 25: 743-745.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 743-745
    • Manadan, A.M.1    Joyce, K.2    Sequeira, W.3
  • 52
    • 0034642066 scopus 로고    scopus 로고
    • Long-term effects of budesonide or nedocromil in children with asthma
    • The Childhood Asthma Management Program Research Group
    • The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. New Eng J Med 2000; 343: 1054-1063.
    • (2000) New Eng J Med , vol.343 , pp. 1054-1063


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