Development of nanostructured lipid carriers (NLC) for controlled delivery of meloxicam

International Journal of Biomedical Nanoscience and Nanotechnology

Volumn 1, Issue 2-4, 2010, Pages 247-266

  Khurana, S ^a   Bedi, P M S ^a   Jain, N K ^b  

^a GURU NANAK DEV UNIVERSITY   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

liquid lipid; meloxicam; microemulsion template strategy; nanostructured lipid carriers; NLC; solid lipid

Indexed keywords

EID: 84860512855     PISSN: 17560799     EISSN: 17560802     Source Type: Journal    
DOI: 10.1504/IJBNN.2010.034654     Document Type: Article

References (59)

1. Bunjes, H., Westesen, K. and Koch, M.H.J. (1996) ‘Crystallization tendency and polymorphic transitions in triglyceride nanoparticles’, Int. J. Pharm., Vol. 129, Nos. 1–2, pp.159–173.
2. Castelli, F., Puglia, C., Sarpietro, M.G., Rizza, L. and Bonina, F. (2005) ‘Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry’, Int. J Pharm., Vol. 304, Nos. 1–2, pp.231–238.
3. Cavalli, R., Marengo, E., Rodriguez, L. and Gasco, M.R. (1996) ‘Effects of some experimental factors on the production process of solid lipid nanoparticles’, Eur. J. Pharm. Biopharm., Vol. 42, No. 2, pp.110–115.
4. Cui, Z. and Mumper, R.J. (2002a) ‘Genetic immunization using nanoparticles engineered from microemulsion precursors’, Pharm. Res., Vol. 19, No. 7, pp.939–946.
5. Cui, Z. and Mumper, R.J. (2002b) ‘Topical immunization using nanoengineered genetic vaccines’, Journal of Controlled Release, Vol. 81, Nos. 1–2, pp.173–184.
6. Cui, Z. and Mumper, R.J. (2002c) ‘Coating of cationized protein on engineered nanoparticles results in enhanced immune responses’, Int. J. Pharm., Vol. 238, Nos. 1–2, pp.229–239.
7. Cui, Z., Lockman, P.R., Atwood, C.S., Hsu, C.H., Gupte, A., Allen, D.D. and Mumper, R.J. (2005) ‘Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer’s and other CNS diseases’, Eur. J. Pharm. Sci., Vol. 59, No. 2, pp.263–272.
8. De Vringer, T. and De Ronde, H.A.G. (1995) ‘Preparation and structure of a water-in-oil cream containing lipid nanoparticles’, J. Pharm. Sci., Vol. 84, No. 4, pp.466–472.
9. Dingler, A. and Gohla, S. (2002) ‘Production of solid lipid nanoparticles (SLN): scaling up feasibilities’, J. Microencapsul., Vol. 19, No. 1, pp.11–16.
10. Eccleston, G.M. (1992) ‘Microemulsions’, in Swarbrick, S. and Boylan, J.C. (Eds.): Encyclopedia of Pharmaceutical Technology, Vol. 9, pp.375–421, Marcel Dekker, New York.
11. Fang, J.Y., Fang, C.L., Liu, C.H. and Su, Y.H. (2008) ‘Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)’, Eur. J. Pharm. Biopharm, Vol. 70, No. 2, pp.633–640.
12. Freitas, C. and Muller, R.H. (1999) ‘Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase’, Eur. J. Pharm. Biopharm, Vol. 47, No. 2, pp.125–132.
13. Garcia-Fuentes, M., Alonso, M.J. and Torres, D. (2005) ‘Design and characterization of a new drug nanocarrier made from solid-liquid lipid mixtures’, J. Colloid Interface Sci., Vol. 285, No. 2, pp.590–598.
14. Gasco, M.R. (1997) ‘Solid lipid nanospheres from warm microemulsions’, Pharm. Tech. Eur., Vol. 9, No. 11, pp.52–59.
15. Gutierrez, J.M., Gonzalez, C., Maestro, A., Sole, I., Pey, C.M. and Nolla, J. (2008) ‘Nano-emulsions: new applications and optimization of their preparation’, Current Opinion in Colloid & Interface Science, Vol. 13, No. 4, pp.245–251.
16. Han, F., Li, S., Yin, R., Liu, H. and Xu, L. (2008) ‘Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: nanostructured lipid Carriers’, Colloids and Surfaces A: Physicochemical and Engineering Aspects., Vol. 315, Nos. 1–3, pp.210–216.
17. Higuchi, W.I. (1962) ‘Analysis of data on the medication release from ointments’, J. Pharm. Sci., Vol. 51, pp.802–804.
18. Hu, F.Q., Jiang, S.P., Du, Y.Z., Yuan, H., Ye, Y.Q. and Zeng, S. (2005) ‘Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system’, Colloids Surf. B. Biointerfaces, Vol. 45, Nos. 3–4, pp.167–173.
19. Jenning, V. and Gohla, S. (2000) ‘Comparison of wax and glyceride solid lipid nanoparticles (SLN)’, Int. J. Pharm., Vol. 196, No. 2, pp.219–222.
20. Jenning, V. and Gohla, S.H. (2001) ‘Encapsulation of retinoids in solid lipid nanoparticles’, J. Microencapsul., Vol. 18, No. 2, pp.149–158.
21. Jenning, V., Schafer-Korting, M. and Gohla, S. (2000a) ‘Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties’, J. Control. Release, Vol. 66, Nos. 2–3, pp.115–126.
22. Jenning, V., Thunemann, A.F. and Gohla, S.H. (2000b) ‘Characterization of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids’, Int. J. Pharm., Vol. 199, No. 2, pp.167–177.
23. Joshi, M. and Patravale, V. (2006) ‘Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib’, Drug Development and Industrial Pharmacy, Vol. 32, No. 8, pp.911–918.
24. Joshi, M. and Patravale, V. (2008) ‘Nanostructured lipid carrier (NLC) based gel of celecoxib’, Int. J. Pharm., Vol. 346, Nos. 1–2, pp.124–132.
25. Lawrence, M.J. and Rees, G.D. (2000) ‘Microemulsion-based media as novel drug delivery systems’, Adv. DrugDeliv. Rev., Vol. 45, No. 1, pp.89–121.
26. Li, X., Nie, S., Kong, J., Li, N., Cheng-Yi, J.U. and Pan, W. (2008) ‘A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers’, Int. J. Pharm., Vol. 363, Nos. 1–2, pp.177–182.
27. Lim, S.J. and Kim, C.K. (2002) ‘Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid’, Int. J. Pharm., Vol. 243, Nos. 1–2, pp.135–146.
28. Liu, W., Yang, X.L., Zhu, Y.L., Chen, H.B. and Xu, H.B. (2005) ‘Nanostructured lipid carriers as vehicles for transdermal iontophoretic drug delivery, Engineering in Medicine and Biology Society’, IEEE-EMBS 27th Annual International Conference, pp.1236–1239.
29. Luger, P., Daneck, K., Engel, W., Trummlitz, G. and Wagner, K. (1996) ‘Structure and physicochemical properties of meloxicam, a new NSAID’, Eur. J. Pharm. Sci., Vol. 4, No. 3, pp.175–187.
30. Mehnert, W. and Mader, K. (2001) ‘Solid lipid nanoparticles: production, characterization and applications’, Adv. Drug Deliv. Rev., Vol. 47, No. 2, pp.165–196.
31. Muller, R.H., Lucks, J.S., Schwarz, C., Zur Muhlen, A., Weyhers, H., Freitas, C. and Ruhl, D. (1995) ‘Solid lipid nanoparticles (SLN) – an alternative colloidal carrier system for controlled drug delivery’, Eur. J. Pharm. Biopham., Vol. 41, No. 1, pp.62–69.
32. Muller, R.H., Mader, K. and Gohla, S. (2000a) ‘Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art’, Eur. J. Pharm. Biopharm., Vol. 50, No. 1, pp.161–177.
33. Muller, R.H., Mader, K., Lippacher, A. and Jenning, V. (2000b) ‘Solid-liquid (semi-solid) lipid particles and method of producing highly concentrated lipid particle dispersion’, German Patent Application, Vol. 199, No. 45, pp.20–32.
34. Muller, R.H., Radtke, M. and Wissing, S.A. (2002a) ‘Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations’, Adv. Drug Deliv. Rev., Vol. 54, No. 1, pp.S131–155.
35. Muller, R.H., Radtke, M. and Wissing, S.A. (2002b) ‘Nanostructured lipid matrices for improved microencapsulation of drugs’, Int. J. Pharm., Vol. 242, Nos. 1–2, pp.121–128.
36. Muller-Goymann, C.C. (2004) ‘Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration’, Eur. J. Pharm. Sci., Vol. 58, No. 2, pp.343–356.
37. Noble, S. and Balfour, J.A. (1996) ‘Meloxicam’, Drugs, Vol. 51, No. 3, pp.424–430.
38. Oyewumi, M.O. and Mumper, R.J. (2002) ‘Gadolinium-loaded nanoparticles engineered from microemulsion templates’, Drug Dev. Ind. Pharm., Vol. 28, No. 3, pp.317–328.
39. Oyewumi, M.O. and Mumper, R.J. (2003) ‘Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles’, Int. J. Pharm., Vol. 251, Nos. 1–2, pp.85–97.
40. Pardeike, J., Hommoss, A. and Muller, R.H. (2009) ‘Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products’, Int. J. Pharm., Vol. 366, Nos. 1–2, pp.170–184.
41. Puglia, C., Filosa, R., Peduto, A., de Caprariis, P., Rizza, L., Bonina, F. and Blasi, P. (2006) ‘Evaluation of alternative strategies to optimize ketorolac transdermal delivery’, AAPS Pharm. Sci. Tech, Vol. 7, No. 3, pp.E1–E9.
42. Ricci, M., Puglia, C., Bonina, F., Di Giovanni, C., Giovagnoli, S. and Rossi, C. (2005) ‘Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies’, J. Pharm. Sci., Vol. 94, No. 5, pp.1149–1159.
43. Schafer-Korting, M., Mehnert, W. and Korting, H.C. (2007) ‘Lipid nanoparticles for improved topical application of drugs for skin diseases’, Adv. Drug Deliv. Rev., Vol. 59, No. 6, pp.427–443.
44. Schwarz, C., Mehnert, W., Lucks, J.S. and Muller, R.H. (1994) ‘Solid lipid nanoparticles (SLN) for controlled drug delivery. I. production, characterization and sterilization’, J. Control. Release, Vol. 30, No. 1, pp.83–96.
45. Seedher, N. and Bhatia, S. (2003) ‘Solubility enhancement of Cox-2 inhibitor using various solvent systems’, AAPS Pharm. Sci. Technol., Vol. 4, No. 3, pp.1–9.
46. Shokri, J., Nokhodchi, A., Dashbolaghi, A., Hassan-Zadeh, D., Ghafourian, T. and Barzegar Jalali, M. (2001) ‘The effect of surfactants on the skin penetration of diazepam’, Int. J. Pharm., Vol. 228, Nos.1–2, pp.99–107.
47. Souto, E.B. and Muller, R.H. (2005) ‘SLN and NLC for topical delivery of ketoconazole’, J. Microencapsul., Vol. 22, No. 5, pp.501–510.
48. Souto, E.B. and Muller, R.H. (2006) ‘The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents’, Pharmazie, Vol. 61, No. 5, pp.431–437.
49. Souto, E.B., Anselmi, C., Centini, M. and Muller, R.H. (2005b) ‘Preparation and characterization of N-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN)’, Int. J. Pharm., Vol. 295, Nos. 1–2, pp.261–268.
50. Souto, E.B., Muller, R.H. and Gohla, S. (2005a) ‘A novel approach based on lipid nanoparticles (SLN) for topical delivery of alpha-lipoic acid’, J. Microencapsul., Vol. 22, No. 6, pp.581–592.
51. Teeranachaideekul, V., Boonme, P., Souto, E.B., Muller, R.H. and Junyaprasert, V.B. (2008) ‘Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC’, J. Control. Release, Vol. 128, No. 2, pp.134–141.
52. Teeranachaideekul, V., Souto, E.B., Junyaprasert, V.B., Rainer, H. and Muller, R.H. (2007) ‘Cetyl palmitate-based NLC for topical delivery of coenzyme Q 10-development, physicochemical characterization and in vitro release studies’, Eur. J. Pharm. Biopahrm., Vol. 67, No. 1, pp.141–148.
53. Uner, M., Wissing, S.A., Yener, G. and Muller, R.H. (2005) ‘Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate’, Pharmazie, Vol. 60, No. 8, pp.577–582.
54. Wang, J.J., Liu, K.S., Sung, K.C., Tsai, C.Y. and Fang, J.Y. (2009) ‘Lipid nanoparticles with different oil/fatty ester ratios as carriers of buprenorphine and its prodrugs for injection’, Eur. J. Pharm. Sci., Vol. 38, No. 2, pp.138–146.
55. Wissing, S.A. and Muller, R.H. (2001) ‘A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles’, Int. J. Cosmet. Sci., Vol. 23, No. 4, pp.233–243.
56. Wissing, S.A. and Muller, R.H. (2003) ‘The influence of solid lipid nanoparticles on skin hydration and viscoelasticity – in vivo study’, Eur. J. Pharm. Biopahrm., Vol. 56, No. 1, pp.67–72.
57. Yang, S.C., Lu, L.F., Cai, Y., Zhu, J.B., Liang, B.W. and Yang, C.Z. (1999) ‘Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain’, J. Control. Release, Vol. 59, No. 3, pp.299–307.
58. Zhang, X.G., Miao, J., Dai, Y.Q., Du, Y.Z., Yuan, H. and Hu, F.Q. (2008) ‘Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells’, Int. J. Pharm., Vol. 361, Nos. 1–2, pp.239–244.
59. Zimmermann, E., Souto, E.B. and Muller, R.H. (2005) ‘Physicochemical investigations on the structure of drug-free and drug-loaded solid lipid nanoparticles (SLN) by means of DSC and ’H NMR’, Pharmazie, Vol. 60, No. 7, pp.508–513.