Allogenic limbo-keratoplasty with conjunctivoplasty, mitomycin C, and amniotic membrane for bilateral limbal stem cell deficiency

Ophthalmology

Volumn 119, Issue 5, 2012, Pages 930-937

  Eberwein, Philipp ^a   Böhringer, Daniel ^a   Schwartzkopff, Johannes ^a   Birnbaum, Florian ^b   Reinhard, Thomas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b KLINIKUM BREMEN MITTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; MITOMYCIN C; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADULT; ALLOGENIC LIMBO KERATOPLASTY; AMNION; ANIRIDIA; ARTICLE; BLEPHARITIS; BURN; CHEMICAL BURN; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC OCULAR SURFACE INFLAMMATION; CICATRIZING PEMPHIGOID; CLINICAL ARTICLE; CONJUNCTIVOPLASTY; CORNEA DISEASE; CORNEA EPITHELIUM; EYE DISEASE; EYE SURGERY; FEMALE; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KERATOPLASTY; LIMBAL STEM CELL DEFICIENCY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TOXIC EPIDERMAL NECROLYSIS; VISUAL ACUITY;

ADULT; ALKYLATING AGENTS; AMNION; CONJUNCTIVA; CORNEAL DISEASES; CYCLOSPORINE; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KERATOPLASTY, PENETRATING; LIMBUS CORNEAE; MALE; MIDDLE AGED; MITOMYCIN; MYCOPHENOLIC ACID; RETROSPECTIVE STUDIES; STEM CELLS; TRANSPLANTATION, HOMOLOGOUS; VISUAL ACUITY;

EID: 84860492242     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2011.10.039     Document Type: Article

References (37)

1. S.C. Tseng Concept and application of limbal stem cells Eye (Lond) 3 1989 141 157 (Pubitemid 20018556)
2. S.C. Tseng Significant impact of limbal epithelial stem cells Indian J Ophthalmol 48 2000 79 81
3. A.M. Yeung, U. Schlotzer-Schrehardt, B. Kulkarni Limbal epithelial crypt: a model for corneal epithelial maintenance and novel limbal regional variations Arch Ophthalmol 126 2008 665 669 (Pubitemid 351679562)
4. G. Cotsarelis, S.Z. Cheng, G. Dong Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells Cell 57 1989 201 209 (Pubitemid 19112360)
5. K.R. Kenyon, S.C. Tseng Limbal autograft transplantation for ocular surface disorders Ophthalmology 96 1989 709 723 (Pubitemid 19119478)
6. G. Pellegrini, C.E. Traverso, A.T. Franzi Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium Lancet 349 1997 990 993 (Pubitemid 27149803)
7. P. Rama, S. Matuska, G. Paganoni Limbal stem-cell therapy and long-term corneal regeneration N Engl J Med 363 2010 147 155
8. R. Sundmacher, T. Reinhard Central corneolimbal transplantation under systemic ciclosporin A cover for severe limbal stem cell insufficiency Graefes Arch Clin Exp Ophthalmol 234 Suppl 1996 S122 S125
9. T. Reinhard, H. Spelsberg, L. Henke Long-term results of allogeneic penetrating limbo-keratoplasty in total limbal stem cell deficiency Ophthalmology 111 2004 775 782 (Pubitemid 38429676)
10. R. Sundmacher, T. Reinhard Homologous lamellar central limbokeratoplasty in severe limbal stem cell deficiency [in German] Klin Monbl Augenheilkd 213 1998 254 255 (Pubitemid 28516899)
11. R. Sundmacher, T. Reinhard, C. Althaus Homologous central limbo-keratoplasty in limbus stem cell damage: retrospective study of 3 years' experience [in German] Ophthalmologe 94 1997 897 901 (Pubitemid 28068020)
12. R. Sundmacher, H. Spelsberg, T. Reinhard Homologous penetrating central limbokeratoplasty in granular and lattice corneal dystrophy Cornea 18 1999 664 670 (Pubitemid 29522038)
13. H. Spelsberg, T. Reinhard, L. Henke Penetrating limbo-keratoplasty for granular and lattice corneal dystrophy: survival of donor limbal stem cells and intermediate-term clinical results Ophthalmology 111 2004 1528 1533 (Pubitemid 39030807)
14. T. Reinhard, R. Sundmacher, H. Spelsberg, C. Althaus Homologous penetrating central limbo-keratoplasty (HPCLK) in bilateral limbal stem cell insufficiency Acta Ophthalmol Scand 77 1999 663 667 (Pubitemid 30006807)
15. L. Liang, W. Li, S. Ling Amniotic membrane extraction solution for ocular chemical burns Clin Experiment Ophthalmol 37 2009 855 863
16. J.J. Gicquel, H.S. Dua, A. Brodie Epidermal growth factor variations in amniotic membrane used for ex vivo tissue constructs Tissue Eng Part A 15 2009 1919 1927
17. U. Keklikci, Y. Celik, S.S. Cakmak Conjunctival-limbal autograft, amniotic membrane transplantation, and intraoperative mitomycin C for primary pterygium Ann Ophthalmol (Skokie) 39 2007 296 301 (Pubitemid 350242583)
18. A. Hopkinson, R.S. McIntosh, P.J. Tighe Amniotic membrane for ocular surface reconstruction: donor variations and the effect of handling on TGF-beta content Invest Ophthalmol Vis Sci 47 2006 4316 4322 (Pubitemid 46579354)
19. A. Hopkinson, R.S. McIntosh, V. Shanmuganathan Proteomic analysis of amniotic membrane prepared for human transplantation: characterization of proteins and clinical implications J Proteome Res 5 2006 2226 2235 (Pubitemid 44330815)
20. M. Bach, M. Wilke, B. Wilhelm Basic quantitative assessment of visual performance in patients with very low vision Invest Ophthalmol Vis Sci 51 2010 1255 1260
21. A. Miri, B. Al-Deiri, H.S. Dua Long-term outcomes of autolimbal and allolimbal transplants Ophthalmology 117 2010 1207 1213
22. L. Liang, H. Sheha, S.C. Tseng Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and correction of ocular surface deficits Arch Ophthalmol 127 2009 1428 1434
23. T. Reinhard, R. Sundmacher, P. Heering Systemic ciclosporin A in high-risk keratoplasties Graefes Arch Clin Exp Ophthalmol 234 Suppl 1996 S115 S121
24. T. Reinhard, T. Kontopoulos, P. Wernet Long-term results of homologous penetrating limbokeratoplasty in total limbal stem cell insufficiency after chemical/thermal burns [in German] Ophthalmologe 101 2004 682 687 (Pubitemid 38969345)
25. T. Reinhard, H. Spelsberg, R. Sundmacher Possibilities and prospects of therapy and prevention of corneal dystrophies [in German] Ophthalmologe 99 2002 427 431
26. S.C. Tseng, M.A. Di Pascuale, D.T. Liu Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases Ophthalmology 112 2005 896 903 (Pubitemid 40631512)
27. S.C. Tseng, P. Prabhasawat, K. Barton Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency Arch Ophthalmol 116 1998 431 441 (Pubitemid 28169742)
28. B.W. Dudney, M.A. Malecha Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia Am J Ophthalmol 137 2004 950 951 (Pubitemid 38582058)
29. P.J. Dougherty, D.R. Hardten, R.L. Lindstrom Corneoscleral melt after pterygium surgery using a single intraoperative application of mitomycin-C Cornea 15 1996 537 540 (Pubitemid 26271794)
30. H.S. Dua, A. Azuara-Blanco Amniotic membrane transplantation Br J Ophthalmol 83 1999 748 752 (Pubitemid 29261669)
31. H.S. Dua, J.A. Gomes, A.J. King, V.S. Maharajan The amniotic membrane in ophthalmology Surv Ophthalmol 49 2004 51 77 (Pubitemid 38056624)
32. M.S. Santos, J.A. Gomes, A.L. Hofling-Lima Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency Am J Ophthalmol 140 2005 223 230
33. S.M. Daya, R.W. Bell, N.E. Habib Clinical and pathologic findings in human keratolimbal allograft rejection Cornea 19 2000 443 450 (Pubitemid 30460876)
34. K. Tsubota, Y. Satake, M. Kaido Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation N Engl J Med 340 1999 1697 1703 (Pubitemid 29252597)
35. A. Solomon, P. Ellies, D.F. Anderson Long-term outcome of keratolimbal allograft with or without penetrating keratoplasty for total limbal stem cell deficiency Ophthalmology 109 2002 1159 1166 (Pubitemid 34546927)
36. L. Ilari, S.M. Daya Long-term outcomes of keratolimbal allograft for the treatment of severe ocular surface disorders Ophthalmology 109 2002 1278 1284 (Pubitemid 34700918)
37. T.R. Henderson, D.J. Coster, K.A. Williams The long term outcome of limbal allografts: the search for surviving cells Br J Ophthalmol 85 2001 604 609 (Pubitemid 32397839)