Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells

Biophysical Journal

Volumn 102, Issue 9, 2012, Pages 2086-2094

  Venegas, Berenice ^a   Zhu, Weiwei ^a   Haloupek, Nicole B ^a   Lee, Janet ^a   Zellhart, Elizabeth ^a   Sugár, István P ^b   Kiani, Mohammad F ^c   Chong, Parkson Lee Gau ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Temple University   (United States)

Author keywords

1,2 dioleoyl sn glycero 3 phosphoethanolamine N (5 dimethylamino 1 naphthalenesulfonyl) (ammonium salt); 1 palmitoyl 2 oleoyl sn glycero 3 phosphocholine; C r; CR,max; Cs,min; CA4; CA4P; combretastatin A4; combretastatin A4 disodium phosphate; critical cholesterol mole fractions theoretically predicted for maximal superlattice formation; Dansyl PE; dehydroergosterol; DHE; LUVs; M CD; methyl cyclodextrin; MLVs; multilamellar vesicles; POPC; the cholesterol mole fractions where the cell survival is minimal (i.e., cytotoxicity is maximal); the cholesterol mole fractions where the initial rate of drug release is maximal; unilamellar vesicles

Indexed keywords

ANTINEOPLASTIC AGENT; COMBRETASTATIN A4 PHOSPHATE; LIPOSOME; STILBENE DERIVATIVE;

ARTICLE; BREAST TUMOR; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG FORMULATION; FEMALE; HUMAN; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG COMPOUNDING; FEMALE; HUMANS; LIPOSOMES; STILBENES;

INSECTIVORA;

EID: 84860491257     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.03.063     Document Type: Article

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