Synthesis, Biological Evaluation, and Structure-activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity

Chemical Biology and Drug Design

Volumn 79, Issue 6, 2012, Pages 943-949

  Menezes, Carla M S ^a   Rivera, Gildardo ^a,b   Alves, Marina A ^a   Do Amaral, Daniel N ^a   Thibaut, Jean Pierre B ^a   Noël, François ^a   Barreiro, Eliezer J ^a   Lima, Lídia M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

1,4 benzodiazepine; Clonazepam; Meclonazepam; Pharmacophoric unit; Schistosomiasis; Structure activity relationship

Indexed keywords

AMIDE; BENZODIAZEPINE DERIVATIVE; CLONAZEPAM; MECLONAZEPAM; NITROGEN;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; DRUG SOLUBILITY; DRUG SYNTHESIS; LIPOPHILICITY; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCHISTOSOMICIDAL ACTIVITY; STRUCTURE ACTIVITY RELATION; WORM;

ANIMALS; BENZODIAZEPINES; BENZODIAZEPINONES; CLONAZEPAM; HUMANS; MODELS, MOLECULAR; SCHISTOSOMA; SCHISTOSOMIASIS; SCHISTOSOMICIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860481848     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01354.x     Document Type: Article

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