Functional analysis of HIV type 1 nef gene variants from adolescent and adult survivors of perinatal infection

AIDS Research and Human Retroviruses

Volumn 28, Issue 5, 2012, Pages 486-492

  Zuo, Jun ^a   Suen, Jeffrey ^a   Wong, Alanna ^a   Lewis, Martha ^a   Ayub, Ali ^a   Belzer, Marvin ^b   Church, Joseph ^b   Yang, Otto O ^a   Krogstad, Paul ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN;

ADOLESCENT; ADULT; ADULTHOOD; ALLELE; AMINO ACID SEQUENCE; ARTICLE; BLOOD TRANSFUSION; CD4+ T LYMPHOCYTE; CELL SURFACE; CLINICAL ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE FUNCTION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INFANCY; LOSS OF FUNCTION MUTATION; MALE; NEF GENE; PERINATAL INFECTION; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; VERTICAL TRANSMISSION; VIRUS GENE; VIRUS TRANSMISSION; WILD TYPE;

ADOLESCENT; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DOWN-REGULATION; FEMALE; GENETIC VARIATION; HIV LONG-TERM SURVIVORS; HIV SEROPOSITIVITY; HIV-1; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LOS ANGELES; MALE; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PHYLOGENY; YOUNG ADULT;

EID: 84860480231     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2011.0172     Document Type: Article

References (23)

1. Bamji M, Thea DM, Weedon J, et al.: Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City. The New York City Perinatal HIV Transmission Collaborative Study Group. Pediatr Infect Dis J 1996;15:891-898. (Pubitemid 26339600)
2. Barnhart HX, Caldwell MB, Thomas P, et al.: Natural history of human immunodeficiency virus disease in perinatally infected children: An analysis from the Pediatric Spectrum of Disease Project. Pediatrics 1996;97:710-716. (Pubitemid 26138104)
3. Galli L, de Martino M, Tovo PA, Gabiano C, and Zappa M: Predictive value of the HIV paediatric classification system for the long-term course of perinatally infected children. Int J Epidemiol 2000;29:573-578. (Pubitemid 30447265)
4. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, and Dabis F: Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: A pooled analysis. Lancet 2004;364:1236-1243. (Pubitemid 39311344)
5. Brady MT, Oleske JM, Williams PL, et al.: Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era. J Acquir Immune Defic Syndr 2010;53:86-94.
6. Gortmaker SL, Hughes M, Cervia J, et al.: Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. N Engl J Med 2001;345:1522-1528. (Pubitemid 33144917)
7. Geyer M, Fackler OT, and Peterlin BM: Structure-function relationships in HIV-1 Nef. EMBO Rep 2001;2:580-585. (Pubitemid 32707703)
8. Laguette N, Bregnard C, Benichou S, and Basmaciogullari S: Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins. Mol Aspects Med 2010;31:418-433.
9. Arhel NJ and Kirchhoff F: Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Curr Top Microbiol Immunol 2009;339:147-175.
10. Greenberg M, DeTulleo L, Rapoport I, Skowronski J, and Kirchhausen T: A dileucine motif in HIV-1 Nef is essentialfor sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 1998;8:1239-1242. (Pubitemid 29006666)
11. Mangasarian A, Piguet V, Wang JK, Chen YL, and Trono D: Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking. J Virol 1999;73:1964-1973. (Pubitemid 29098098)
12. Kestler HW, 3rd, Ringler DJ, Mori K, et al.: Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991;65:651-662.
13. Swigut T, Alexander L, Morgan J, et al.: Impact of Nefmediated downregulation ofmajor histocompatibility complex class I on immune response to simian immunodeficiency virus. J Virol 2004;78:13335-13344. (Pubitemid 39507838)
14. Geffin R, Wolf D, Muller R, et al.: Functional and structural defects in HIV type 1 nef genes derived from pediatric longtermsurvivors. AIDS ResHumRetroviruses 2000;16:1855-1868.
15. Rousseau C, Abrams E, Lee M, Urbano R, and King MC: Long terminal repeat and nef gene variants of human immunodeficiency virus type 1 in perinatally infected longterm survivors and rapid progressors. AIDS Res Hum Retroviruses 1997;13:1611-1623. (Pubitemid 28009367)
16. Walker PR, Ketunuti M, Choge IA, et al.: Polymorphisms in Nef associated with different clinical outcomes in HIV type 1 subtype C-infected children. AIDS Res Hum Retroviruses 2007;23:204-215. (Pubitemid 46418334)
17. Tzitzivacos DB, Tiemessen CT, Stevens WS, and Papathanasopoulos MA: Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children. AIDS Res Hum Retroviruses 2009;25:1141-1148.
18. Pham T, Belzer M, Church JA, et al.: Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circles. Clin Diagn Lab Immunol 2003;10:323-328. (Pubitemid 36314460)
19. Lee JC, Boechat MI, Belzer M, et al.: Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy. AIDS 2006;20:667-674. (Pubitemid 43884293)
20. Yang OO, Church J, Kitchen CM, et al.: Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins. J Virol 2005;79:15368-15375. (Pubitemid 43032319)
21. Ali A, Realegeno S, Yang OO, and Lewis MJ: Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection. J Virol Methods 2009,161:297-304.
22. Buseyne F, Janvier G, Teglas JP, et al.: Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age. J Infect Dis 1998;178:1019-1023. (Pubitemid 28452193)
23. Lewis MJ, Balamurugan A, Ohno A, Kilpatrick S, Ng HL, and Yang OO: Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo. J Immunol 2008;180:4075-4081.