Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis

Journal of Pharmacy and Bioallied Sciences

Volumn 4, Issue SUPPL., 2012, Pages 10-11

  Pawar, Vijay ^a   Gohil, Virpal ^a   Tamboli, Riyaj ^a   Giridhar, Rajani ^a   Yadav, Mange Ram ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

arthritis; COX; NSAIDs

Indexed keywords

ESTER DERIVATIVE; IBUPROFEN; IBUPROFEN TROPINOL ESTER DERIVATIVE; NAPROXEN; NAPROXEN TROPINOL ESTER DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; QUATERNARY ESTER DERIVATIVE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTHRITIS; BINDING AFFINITY; CARTILAGE; CONFERENCE PAPER; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG PURITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMAGING; IN VITRO STUDY; INFLAMMATION; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 84860475786     PISSN: None     EISSN: 09757406     Source Type: Journal    
DOI: 10.4103/0975-7406.94119     Document Type: Conference Paper

References (3)

1. Giraud I, Rapp M, Maurizis J, Madelmont J. Application to a cartilage targeting strategy: Synthesis and in vivo biodistribution of 14c-labeled quaternary ammonium-glucosamine conjugates. Bioconjugate Chem 2000;11:212-8. (Pubitemid 30174488)
2. Nicolas C, Verny M, Giraud I, Oller M, Rapp M, Maurizis J, et al. New quaternary ammonium oxicam derivatives targeted toward cartilage: Synthesis. pharmacokinetic studies, and anti-inflammatory potency. J Med Chem 1999;42:5235.
3. Yadav MR, Pawar VA, Marvaniya SM, Halen PK, Giridhar R, Mishra AK. Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and c-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites. Bioorg Med Chem 2008;16:9443-9.