Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3506-3515

  Ikeda, Reiko ^a   Kimura, Takanori ^a   Tsutsumi, Tatsuya ^a   Tamura, Syunsuke ^a   Sakai, Norio ^a   Konakahara, Takeo ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Carboline; Antitumor drug; Apoptosis; Cell cycle in the G2 M phase; Structure activity relationship

Indexed keywords

3 (3 PHENOXYBENZYL)AMINO BETA CARBOLINE; 3 BENZYLAMINO 6 CHLORO BETA CARBOLINE; 3 BENZYLAMINO 8 METHYLAMINO BETA CARBOLINE; 3 BENZYLAMINO BETA CARBOLINE; 8 METHYLAMINO 3 (3 PHENOXYBENZYL)AMINO BETA CARBOLINE; BENZYLAMINE DERIVATIVE; BETA CARBOLINE DERIVATIVE; N (3 BENZYLAMINO 9H BETA CARBOLIN 8 YL)BENZAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DNA DEGRADATION; DNA DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HELA CELL; SARCOMA 180; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARBOLINES; HELA CELLS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860468607     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.077     Document Type: Article

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