Bronchial and alveolar components of exhaled nitric oxide and their relationship

European Respiratory Journal

Volumn 39, Issue 5, 2012, Pages 1258-1261

  Verbanck, Sylvia ^a   Malinovschi, Andrei ^a,c   George, Steven ^d   Gelb, Arthur F ^e,f   Vincken, Walter ^a   Van Muylem, Alain ^b  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c UPPSALA UNIVERSITY   (Sweden)

^d University of California at Irvine   (United States)

^e Lakewood Regional Medical Center   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; STEROID;

AIRWAY CONSTRICTION; ASTHMA; BRONCHUS; CONCENTRATION (PARAMETERS); EXHALATION; GAS TRANSPORT; HUMAN; LETTER; LUNG ALVEOLUS; LUNG DIFFUSION; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

BIOLOGICAL MARKERS; BREATH TESTS; BRONCHI; HUMANS; INFLAMMATION; NITRIC OXIDE; PULMONARY ALVEOLI;

EID: 84860455428     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00105611     Document Type: Letter

References (35)

1. Tsoukias NM, Tannous Z, Wilson AF, et al. Single-exhalation profiles of NO and CO2 in humans: effect of dynamically changing flow rate. J Appl Physiol 1998; 85: 642-652. (Pubitemid 28365834)
2. Pietropaoli AP, Perillo IB, Torres A, et al. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J Appl Physiol, 87: 1532-1542.
3. Condorelli P, Shin HW, Aledia AS, et al. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. J Appl Physiol 2007; 102: 417-425. (Pubitemid 46089793)
4. Kerckx Y, Michils A, Van Muylem A. Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients. J Appl Physiol 2008; 104: 918-924. (Pubitemid 351507926)
5. Verbanck S, Kerckx Y, Schuermans D, et al. Effect of airways constriction on exhaled nitric oxide. J Appl Physiol 2008; 104: 925-930. (Pubitemid 351507927)
6. Berry M, Hargadon B, Morgan A, et al. Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J 2005; 25: 986-991. (Pubitemid 40823772)
7. Fritscher LG, Rodrigues MT, Zamel N, et al. The effect of montelukast on exhaled nitric oxide of alveolar and bronchial origin in inhaled corticosteroid-treated asthma. Respir Med 2009; 103: 296-300.
8. Kanazawa H, Kyoh S, Asai K, et al. Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma. J Asthma 2010; 47: 400-406.
9. Nicolini G, Chetta A, Simonazzi A, et al. Both bronchial and alveolar exhaled nitric oxide are reduced with extrafine beclomethasone dipropionate in asthma. Allergy Asthma Proc 2010; 31: 85-90.
10. Williamson PA, Menzies D, Nair A, et al. A proof-of-concept study to evaluate the antiinflammatory effects of a novel soluble cyclodextrin formulation of nebulized budesonide in patients with mild to moderate asthma. Ann Allergy Asthma Immunol 2009; 102: 161-167.
11. Brindicci C, Ito K, Barnes PJ, et al. Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers. Chest 2007; 132: 581-588. (Pubitemid 47282392)
12. Cohen J, Douma WR, ten Hacken NH, et al. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008; 31: 1213-1220.
13. Gelb AF, Taylor CF, Shinar CM, et al. Effect of fluticasone 250 mg/salmeterol 50 mg and montelukast on exhaled nitric oxide in asthmatic patients. Can Respir J 2008; 15: 193-198.
14. Gelb AF, Taylor CF, Simmons M, et al. Role of add-on zileuton on total exhaled, large airway, and small airway/alveolar nitric oxide in moderate-severe persistent adult asthmatics on fluticasone 250 mg/salmeterol 50 mg. Pulm Pharmacol Ther 2009; 22: 516-521.
15. Gelb AF, George SC, Silkoff PE, et al. Central and peripheral airway/alveolar sites of exhaled nitric oxide in acute asthma. Thorax 2010; 65: 619-625.
16. Lehtimä ki L, Kankaanranta H, Saarelainen S, et al. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med 2001; 163: 1557-1561.
17. Lehtimä ki L, Kankaanranta H, Saarelainen S, et al. Inhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma. Eur Respir J 2001; 18: 635-639.
18. Spears M, Weir CJ, Smith AD, et al. Bronchial nitric oxide flux (J9aw) is sensitive to oral corticosteroids in smokers with asthma. Respir Med 2011; 105: 1823-1830.
19. Van Muylem A, Kerckx Y, Michils A. Acinar effect of inhaled steroids evidenced by exhaled nitric oxide. J Allergy Clin Immunol 2010; 126: 730-735.
20. Williamson PA, Clearie K, Vaidyanathan S, et al. Effects of methacholine challenge on alveolar nitric oxide. Thorax 2009; 64: 549-550.
21. Brindicci C, Ito K, Barnes PJ, et al. Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest 2007; 131: 1353-1362. (Pubitemid 46762339)
22. Delclaux C, Mahut B, Zerah-Lancner F, et al. Increased nitric oxide output from alveolar origin during liver cirrhosis versus bronchial source during asthma. Am J Respir Crit Care Med 2002; 165: 332-337. (Pubitemid 34118504)
23. Gelb AF, Taylor CF, Nussbaum E, et al. Alveolar and airway sites of nitric oxide inflammation in treated asthma. Am J Respir Crit Care Med 2004; 170: 737-741. (Pubitemid 39298987)
24. Gelb AF, Taylor CF, Shinar CM, et al. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest 2006; 129: 1492-1499. (Pubitemid 43894977)
25. Kerckx Y, Michils A, Van Muylem A. Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients. J Appl Physiol 2008; 104: 918-924. (Pubitemid 351507926)
26. Kobayashi D, Tochino Y, Kanazawa H, et al. Comparison of alveolar nitric oxide concentrations using two different methods for assessing small airways obstruction in asthma. Respirology 2011; 16: 862-868.
27. Lehtimä ki L, Turjanmaa V, Kankaanranta H, et al. Increased bronchial nitric oxide production in patients with asthma measured with a novel method of different exhalation flow rates. Ann Med 2000; 32: 417-423.
28. Lehtimä ki L, Kankaanranta H, Saarelainen S, et al. Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms. Eur Respir J 2002; 20: 841-845.
29. Lehtimä ki L, Kankaanranta H, Saarelainen S, et al. Peripheral inflammation in patients with asthmatic symptoms but normal lung function. J Asthma 2005; 42: 605-609.
30. Mahut B, Trinquart L, Le Bourgeois M, et al. Multicentre trial evaluating alveolar NO fraction as a marker of asthma control and severity. Allergy 2010; 65: 636-644.
31. Matsumoto H, Niimi A, Jinnai M, et al. Association of alveolar nitric oxide levels with pulmonary function and its reversibility in stable asthma. Respiration 2011; 81: 311-317.
32. Nihlberg K, Andersson-Sjöland A, Tufvesson E, et al. Altered matrix production in the distal airways of individuals with asthma. Thorax 2010; 65: 670-676.
33. Van Veen IH, Sterk PJ, Schot R, et al. Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma. Eur Respir J 2006; 27: 951-956. (Pubitemid 44911108)
34. Verbanck S, Schuermans D, Vincken W. Inflammation and airway function in the lung periphery of patients with stable asthma. J Allergy Clin Immunol 2010; 125: 611-616.
35. Williamson PA, Clearie K, Menzies D, et al. Assessment of smallairways disease using alveolar nitric oxide and impulse oscillometry in asthma and COPD. Lung 2011; 189: 121-129.