A new "Era" for the α7-nAChR

Current Drug Targets

Volumn 13, Issue 5, 2012, Pages 721-725

  Russo, Patrizia ^a   Cardinale, Alessio ^b   Shuller, Hildegard ^c  

^a Non Communicable Diseases   (Italy)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Biological activity; Future perspectives; New drugs; Toxins; 7 nAChR

Indexed keywords

4 AMINOBUTYRIC ACID; BUNGAROTOXIN RECEPTOR; COBROTOXIN; NICOTINE; PROTEIN BCL 2; SNAKE VENOM; TOXIN;

ALZHEIMER DISEASE; ANXIETY; ARTICLE; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; DEPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; MALIGNANT TRANSFORMATION; NEOPLASM; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PAIN; PARKINSON DISEASE; RECEPTOR BINDING; SOCIAL STRESS;

EID: 84860452173     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012800398946     Document Type: Article

References (47)

1. Russo P, Nastrucci C, Alzetta G, Szalai C. Tobacco habit: historical, cultural, neurobiological and genetical features of people's relationship with an addictive drug. Perspect Biol Med 2011; 54: 557-77.
2. Eccles JC, Katz B, Kuffler SW. Nature of the end-plate potential in curarized muscle. J Neurophysiol 1941; 127: 362-87.
3. Yakel JL. Gating of nicotinic ACh receptors: latest insights into ligand binding and function. J Physiol 2010; 588(Pt 4): 597-602.
4. Whittaker VP. Identification of acetylcholine and related esters of biological origin. In: Eichler O, Farah A, Koelle GB, Eds. Handbuch der experimentellen Pharmakologie Bd, vol. 15. Berlin: Springer 1963; p. 1-39.
5. Wessler I, Kirkpatrick CJ, Racké K. The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol 1999; 26: 198-205.
6. Servent D, Thanh HL, Antil S, et al. Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors. J Physiol Paris 1998; 92: 107-11.
7. Campos F, Alfonso M, Durán R. In vivo modulation of alpha7 nicotinic receptors on striatal glutamate release induced by anatoxin-A. Neurochem Int 2010; 56: 850-5.
8. Miwa JM, Stevens TR, King SL, et al. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron 2006; 51: 587-600.
9. Grando SA. Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors. J Pharmacol Sci 2008; 106: 174-9.
10. Eastham HM, Lind RJ, Eastlake JL, et al. Characterization of a nicotinic acetylcholine receptor from the insect Manduca sexta. Eur J Neurosci 1998; 10: 879-89.
11. Asher O, Lupu-Meiri M, Jensen BS, Paperna T, Fuchs S, Oron Y. Functional characterization of mongoose nicotinic acetylcholine receptor alpha-subunit: resistance to alpha-bungarotoxin and high sensitivity to acetylcholine. FEBS Lett 1998; 431: 411-4.
12. Araud T, Graw S, Berger R, et al. The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochem Pharmacol 2011; 82(8): 904-914.
13. Orr-Urtreger A, Broide RS, Kasten MR, et al. Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem 2000; 74: 2154-2166.
14. Broide RS, Orr-Urtreger A, Patrick JW. Normal apoptosis levels in mice expressing one alpha7 nicotinic receptor null and one L250T mutant allele. Neuroreport 2001; 12: 1643-8.
15. Young JW, Meves JM, Tarantino IS, Caldwell S, Geyer MA. Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice. Genes Brain Behav 2011; 10: 720-33.
16. Nguyen VT, Arredondo J, Chernyavsky AI, et al. Abnormalities of keratinocyte functions in the epidermis of knockout mice lacking the neuronal nicotinic acetylcholine receptor subunits α3, α7 or β4 (abstr #95.). J Invest Derm 2001; 117: 405.
17. Arredondo J, Nguyen VT, Chernyavsky AI, et al. Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life Sci 2003; 72: 2063-7.
18. Russo P, Taly A. α7-Nicotinic Acetylcholine Receptors: an old actor for new different roles. Curr Drug Targets 2012; 13(5): 574-578.
19. Palma E, Conti L, Roseti C, Limatola C. Novel approaches to study the involvement of α7-nAChR in human diseases. Curr Drug Targets 2012; 13(5): 579-86.
20. Aluigi MG, Diaspro A, Ramoino P, Russo P, Falugi C. The sea urchin, Paracentrotus lividus, as a model to investigate the onset of molecules immunologically related to the α-7 subunit of nicotinic receptors during embryonic and larval development. Curr Drug Targets 2012; 13(5): 587-93.
21. Brust P, Peters D, Deuther-Conrad W. Development of radioligands for the imaging of α7 nicotinic acetylcholine receptors with positron emission tomography. Curr Drug Targets 2012; 13(5): 594-601.
22. Falugi C, Lammerding-Koppel M, Aluigi MG. Sea urchin development: an alternative model for mechanistic understanding of neurodevelopment and neurotoxicity. Birth Defects Res C Embryo Today 2008; 84: 188-203.
23. Levin ED. α 7 Nicotinic Receptors and Cognition. Curr Drug Targets 2012; 13(5): 602-606.
24. Hunter RG. Stress and the α7 Nicotinic Acetylcholine Receptor. Curr Drug Targets 2012; 13(5): 607-12.
25. Hernandez CM, Dineley KT. α7 nicotinic acetylcholine receptors in Alzheimer's disease: neuroprotective, neurotrophic or both? Curr Drug Targets 2012; 13(5): 613-22.
26. Kawamata J, Syuuichirou Suzuki S, Shimohama S. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Curr Drug Targets 2012; 13(5): 623-30.
27. Kelso ML, Oestreich JH.Traumatic brain injury: central and peripheral role of α7 nicotinic acetylcholine receptors. Curr Drug Targets 2012; 13(5): 631-6.
28. Neri M, Bonassi S, Russo P. Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia. Curr Drug Targets 2012; 13(5): 637-43.
29. Filippini P, Cesario A, Fini M, Locatelli F, Rutella S. The yin and yang of non-neuronal α7-nicotinic receptors in inflammation and autoimmunity. Curr Drug Targets 2012; 13(5): 644-55.
30. Lin W, Hirata N, Sekino Y, Kanda Y. Role of α7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells. Curr Drug Targets 2012; 13(5): 656-65.
31. Nastrucci C, Russo P. α7 nAChR in airway respiratory epithelial cells. Curr Drug Targets 2012; 13(5): 666-70.
32. Pillai S, Chellappan S. α7 nicotinic acetylcholine receptor subunit in Angiogenesis and Epithelial To Mesenchymal Transition. Curr Drug Targets 2012; 13(5): 671-9.
33. Schuller HM. Regulatory role of the α7nAChR in cancer. Curr Drug Targets 2012; 13(5): 680-7.
34. Cesario A, Russo P, Nastrucci C, Granone P. Is α7-nAChR a possible target for lung cancer and malignant pleural mesothelioma treatment? Curr Drug Targets 2012; 13(5): 688-94.
35. Taly A, Charon S. α7 Nicotinic acetylcholine receptors: a therapeutic target in the structure era. Curr Drug Targets 2012; 13(5): 695-706.
36. Thomsen MS, Mikkelsen JD. The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets? Curr Drug Targets 2012; 13(5): 707-720.
37. Graef S, Schönknecht P, Sabri O, Hegerl U. Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings. Psychopharmacology 2011; 215: 205-29.
38. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology 2010; 35: 217-38.
39. Russo P, Cesario A, Rutella S, et al. Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment. Curr Med Chem 2011; 18: 91-112.
40. Pacini A, Di Cesare Mannelli L, et al. Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain 2010; 150: 542-549.
41. Robinson L, Platt B, Riedel G. Involvement of the cholinergic system in conditioning and perceptual memory. Behav Brain Res 2011; 221: 443-65.
42. Higley MJ, Strittmatter SM. Neuroscience. Lynx for braking plasticity. Science 2010; 30: 1189-90.
43. Kumar P, Meizel S. Nicotinic acetylcholine receptor subunits and associated proteins in human sperm. J Biol Chem 2005; 280: 25928-25935.
44. Al-Wadei HA, Plummer HK 3rd, Ullah MF, Unger B, Brody J, Schuller HM. Social stress promotes and {gamma}-aminobutyric acid inhibits tumor growth in mouse models of non small cell lung cancer. Cancer Prev Res (Phila) 2011; [Epub ahead of print].
45. Schuller HM, Al-Wadei HA, Majidi M. Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. Carcinogenesis 2008; 29: 1979-85.
46. Catassi A, Servent D, Paleari L, Cesario A, Russo P. Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis. Mutat Res (Rev) 2008; 659: 221-231.
47. Cardinale A, Nastrucci C, Cesario A, Russo P. Nicotine: specific role in angiogenesis, proliferation and apoptosis. Crit Rev Toxicol 2011; 41: 965-86.