Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems

Thrombosis and Haemostasis

Volumn 107, Issue 5, 2012, Pages 951-961

  Sen, Prosenjit ^a   Clark, Curtis A ^a   Gopalakrishnan, Ramakrishnan ^a   Hedner, Ulla ^b   Esmon, Charles T ^c   Pendurthi, Usha R ^a   Vijaya Mohan Rao, L ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Endothelial cell protein C receptor; Factor VIIa; Protein C

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 7A; CALCIUM ION; DROTRECOGIN; ENDOTHELIAL PROTEIN C RECEPTOR; MAGNESIUM ION; PROTEIN C; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; BLOOD COAGULATION FACTOR INHIBITORS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FACTOR VIIA; GLYCOPROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; MAGNESIUM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN C; PROTEIN C INHIBITOR; RADIOLIGAND ASSAY; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SURFACE PLASMON RESONANCE;

EID: 84860449128     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-09-0672     Document Type: Article

References (29)

1. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109: 3161-3172.
2. Ghosh S, Pendurthi UR, Steinoe A, et al. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 2007; 282: 11849-11857.
3. Preston RJ, Ajzner E, Razzari C, et al. Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem 2006; 281: 28850-28857.
4. Lopez-Sagaseta J, Montes R, Puy C, et al. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost 2007; 5: 1817-1824.
5. Nayak RC, Sen P, Ghosh S, et al. Endothelial cell protein C receptor cellular localization and trafficking. Blood 2009; 114: 1974-1986.
6. Sen P, Gopalakrishan R, Kothari H, et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 2011; 117: 3199-3208.
7. Schuepbach RA, Riewald M. Coagulation factor Xa cleaves protease-activated re-ceptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost 2010; 8: 379-388.
8. Disse J, Petersen HH, Larsen KS, et al. The endothelial protein c receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem 2011; 286: 5756-5767.
9. Puy C, Hermida J, Montes R. Factor X and factor VII binding to endothelial protein C receptor differs between species. J Thromb Haemost 2011; 9: 1255-1257.
10. Sen P, Nayak R, Clark CA, Gopalakrishan R, Esmon CT, Pendurthi UR, et al. Factor X binding to endothelial cell protein C receptor: A comparison with factor VIIa and activated protein C. Blood 2011; 118: 2635-2636.
11. Byrne R, Amphlett GW, Castellino FJ. Metal ion specificity of the conversion of bovine factors IX, IX alpha, and IXa alpha to bovine factor IXa beta. J Biol Chem 1980; 255: 1430-1435.
12. Sen P, Sahoo S, Pendurthi UR, et al. Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem 2010; 285: 20410-20420.
13. Church WR, Boulanger LL, Messier TL, et al. Evidence for a common metal ion-dependent transition in the 4-carboxyglutamic acid domains of several vitamin K-dependent proteins. J Biol Chem 1989; 264: 17882-17887.
14. Butenas S, Lawson JH, Kalafatis M, et al. Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa. Biochem 1994; 33: 3449-3456.
15. Bajaj S P, Schmidt AE, Agah S, et al. High resolution structures of p-aminobenza-midine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. J Biol Chem 2006; 281: 24873-24888.
16. Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J 1990; 266: 625-636.
17. Friedman PA, Przysiecki CT. Vitamin K-dependent carboxylation. Int J Biochem 1987; 19: 1-7.
18. Freedman SJ, Blostein MD, Baleja JD, et al. Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX. J Biol Chem 1996; 271: 16227-16236.
19. Villoutreix BO, Blom AM, Dahlback B. Structural prediction and analysis of en-dothelial cell protein C/activated protein C receptor. Protein Eng 1999; 12: 833-840.
20. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, et al. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93: 10212-10216.
21. Li W, Zhen g X, Gu J, et al. Overexpressin g endothelial cell protei n C rece ptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost 2005; 3: 1351-1359.
22. Rao LVM, Williams T, Rapaport SI. Studies of the activation of factor VII bound to tissue factor. Blood 1996; 87: 3738-3748.
23. Li W, Zheng X, Gu JM, et al. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 2005; 106: 2716-2722.
24. Gopalakrishnan R, Hedner U, Ghosh S, et al. Bio-distribution of pharmacologically administered rFVIIa. J Thromb Haemost 2010; 8: 301-310.
25. Rao LVM, Bajaj S P, Rapaport SI. Activation of human factor VII during clotting in vitro. Blood 1985; 65: 218-226.
26. Puy C, Lopez-Sagaseta J, Hermida J, et al. The endothelial cells downregulate the generation of factor VIIa through EPCR binding. Br J Haematol 2010; 149: 111-117.
27. Petersen LC, Norby PL, Branner S, et al. Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study. Thromb Res 2005; 116: 75-85.
28. Pawlinski R, Tencati M, Holscher T, et al. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost 2007; 5: 1693-1700.
29. Regan LM, Mollica JS, Rezaie AR, et al. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem 1997; 272: 26279-26284.