Factor X binding to endothelial cell protein C receptor: Comparison with factor VIIa and activated protein C

Blood

Volumn 118, Issue 9, 2011, Pages 2635-2636

  Sen, Prosenjit ^a   Nayak, Ramesh ^a   Clark, Curtis A ^a   Gopalakrishnan, Ramakrishnan ^a   Esmon, Charles T ^b   Pendurthi, Usha R ^a   Rao, L Vijaya Mohan ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A; ENDOTHELIAL PROTEIN C RECEPTOR;

CONTROLLED STUDY; HUMAN; HUMAN CELL; LETTER; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 80052465786     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-354571     Document Type: Letter

References (7)

1. Ghosh S., Pendurthi U.R., Steinoe A., Esmon C.T., Rao L.V. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem. 2007;282(16):11849-11857. (Pubitemid 47100682)
2. Preston R.J., Ajzner E., Razzari C. et al. Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem. 2006;281(39):28850- 28857. (Pubitemid 44507028)
3. Lopez-Sagaseta J., Montes R., Puy C. et al. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost. 2007;5(9):1817-1824. (Pubitemid 47288936)
4. Disse J., Petersen H.H., Larsen K.S. et al. The endothelial protein c receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem. 2011;286(7):5756-5767.
5. Schuepbach R.A., Riewald M. Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost. 2010;8(2):379-388.
6. Li W., Zheng X., Gu J. et al. Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost. 2005;3(7):1351-1359. (Pubitemid 41725187)
7. Bae J.S., Yang L., Rezaie A.R. Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem. 2010;285(45):34803-34812.