Removal of potentially genotoxic acetamide and arylsulfonate impurities from crude drugs by molecular imprinting

Journal of Chromatography A

Volumn 1240, Issue , 2012, Pages 52-58

  Székely, György ^a,b   Fritz, Emelie ^a   Bandarra, Joao ^b   Heggie, William ^b   Sellergren, Börje ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b Hovione FarmaCiencia SA   (Portugal)

Author keywords

API purification; Genotoxic impurities; Molecular imprinting; Solid phase extraction

Indexed keywords

ACRYLAMIDES; ACTIVE PHARMACEUTICAL INGREDIENTS; ARYLSULFONATES; BENZAMIDES; CRUDE DRUGS; FORMAMIDES; GENOTOXIC; GENOTOXIC IMPURITIES; MEMORY EFFECTS; METHACRYLAMIDES; METHYL TOSYLATE; MOLECULAR IMPRINTING; MOLECULARLY IMPRINTED POLYMER; N-TERT-BUTYLACRYLAMIDE; QUANTITATIVE REMOVAL; REMOVAL EFFICIENCIES; SOLID-PHASE EXTRACTION;

AMIDES; AROMATIC COMPOUNDS; BIOSYNTHESIS; MOLECULAR MODELING; POLYMERIZATION; POLYMERS; SULFUR COMPOUNDS;

REMOVAL;

ACETAMIDE; ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; ARYLSULFONIC ACID DERIVATIVE; BENZAMIDE; FORMAMIDE; METHACRYLAMIDE; N TERT BUTYLACRYLAMIDE; POLYMER; ULOBETASOL PROPIONATE; UNCLASSIFIED DRUG;

ADSORPTION KINETICS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG IMPURITY; DRUG PURIFICATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR IMPRINTING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; VALIDATION PROCESS;

ACETAMIDES; ARYLSULFONATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHACRYLATES; MOLECULAR IMPRINTING; MUTAGENS; PHARMACEUTICAL PREPARATIONS; SOLID PHASE EXTRACTION;

APIS;

EID: 84860433459     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.092     Document Type: Article

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