A hybrid approach to reach stringent low genotoxic impurity contents in active pharmaceutical ingredients: Combining molecularly imprinted polymers and organic solvent nanofiltration for removal of 1,3-diisopropylurea

Separation and Purification Technology

Volumn 86, Issue , 2012, Pages 79-87

  Székely, György ^a,b   Bandarra, Joao ^a   Heggie, William ^a   Sellergren, Börje ^b   Ferreira, Frederico Castelo ^c  

^a Hovione FarmaCiencia SA   (Portugal)

^b TU DORTMUND UNIVERSITY   (Germany)

^c INSTITUTO SUPERIOR TÉCNICO   (Portugal)

Author keywords

API purification; Genotoxic impurities; Molecularly imprinted polymers; Organic solvent nanofiltration

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; DIAFILTRATION; DILUTION RATIO; ELUTION SYSTEMS; GENOTOXIC IMPURITIES; HYBRID APPROACH; METHYL ISOBUTYL KETONE; MOLECULAR SIZE; MOLECULARLY IMPRINTED POLYMER; ORGANIC SOLVENT NANOFILTRATION; SINGLE STAGE;

DICHLOROMETHANE; IMPURITIES; KETONES; METHANOL; NANOFILTRATION; ORGANIC POLYMERS; ORGANIC SOLVENTS; POLISHING; PURIFICATION; SOLVENTS; SORPTION;

REMOVAL;

APIS;

EID: 84856345433     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2011.10.023     Document Type: Article

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