Microwave-assisted Synthesis and Bioevaluation of Some Semicarbazones

Chemical Biology and Drug Design

Volumn 79, Issue 6, 2012, Pages 950-959

  Jafri, Laila ^a   Ansari, Farzana L ^a   Jamil, Maryam ^a   Kalsoom, Saima ^a   Qureishi, Sana ^a   Mirza, Bushra ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

Author keywords

Antibacterial; Antifungal; Antioxidant; Antitumor; DNA protection; Semicarbazones

Indexed keywords

1 (1 (2,4 DIHYDROXYPHENYL) ETHYLIDENE) 4 PHENYLSEMICARBAZONE; 1 (1 (3 AMINOPHENYL) ETHYLIDENE) 4 PHENYLSEMICARBAZONE; 1 (1 (ANTHRACEN 2 YL)ETHYLIDENE) 4 PHENYLSEMICARBAZONE; 1 (1 (FERROCEN 2 Y)ETHYLIDENE) 4 PHENYLSEMICARBAZONE; 1 (1H IMIDAZOL 2(3H) YLIDENE) 4 PHENYLSEMICARBAZONE; 1 (2 METHYL 2,3 DIHYDROBENZO[B][1,4]THIAZEPIN 4(5H) YLIDENE) 4 PHENYLSEMICARBAZONE; 1 (2 OXO 5 PHENYLIMIDAZOLIDIN 4 YLIDENE) 4 PHENYL SEMICARBAZONE; 1 (2 OXO 5,5 DIPHENYLIMIDAZOLIDIN 4 YLIDENE) 4 PHENYL SEMICARBAZONE; 1 (2 OXOINDOLIN 3 YLIDENE) 4 PHENYLSEMICARBAZONE; 1 (4 METHYL 4,5 DIHYDRO 1 HBENZO[B][1,4]DIAZEPIN 2(3H) YLIDENE) 4 PHENYLSEMICARBAZONE; 1 (4 METHYL 8 NITRO 4,5 DIHYDRO 1H BENZO[B][1,4]DIAZEPIN 2(3H) YLIDENE) 4 PHENYLSEMICARBAZONE; 1 (4 NITRO 1 H BENZO[D] IMIDAZOL 2(3H) YLIDENE) 4 PHENYLSEMICARBAZONE; 1,1 DIPHENYL 2 PICRYLHYDRAZYL; 4 (2,4 DINITROPHENYL) 1 (2 OXOINDOLIN 3 YLIDENE) SEMICARBAZONE; 4 (2,4 DINITROPHENYL) 1 (4 METHYL 4,5 DIHYDRO 1H BENZO[B][1,4]DIAZEPIN 2(3H) YLIDENE) 4 PHENYLSEMICARBAZONE; 4 PHENYL 1 (1 (THIOPHEN 2 YL)ETHYLIDENE)SEMICARBAZONE; 4 PHENYL 1 (5 VINYL 1H PYRROL 2 (3H) YLIDENE)SEMICARBAZONE; ACETOPHENONE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; NITROBENZENE DERIVATIVE; SCAVENGER; SEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DRUG DEVELOPMENT; DRUG SYNTHESIS; IC 50; MICROWAVE IRRADIATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BACTERIA; CELL LINE, TUMOR; DNA DAMAGE; FUNGI; MICROBIAL SENSITIVITY TESTS; MICROWAVES; SEMICARBAZIDES;

SOLANUM TUBEROSUM;

EID: 84860431578     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01360.x     Document Type: Article

References (27)

1. Beraldo H., Gambino D. (2004) Wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes. Mini Rev Med Chem;4:159-165.
2. Hlavá J., Buchtík R., Slouka J., Haradil P., Wiedermannová I. (2004) Synthesis of oxo analogs of lamotrigine and related compounds. Chem Abstr;140:96.
3. Pirrung M.C., Pansare S.V. (2001) Tritylisothiocyanate support for solid-phase synthesis. J Comb Chem;3:90-96.
4. Laly S., Parameswaran G. (1993) Synthesis and characterization of some thiosemicarbazone complexes of Ag (I), Pt (II) and Pd (II). Asian J Chem;5:712-718.
5. Afrasiabi Z., Shin E., Lin Wma Y., Campana C., Padhye S. (2005) Nickel (II) complexes of naphthaquinonethiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy and biological activity. J Inorg Biochem;99:1526-1531.
6. Aggarwal N., Mishra P. (2004) Synthesis and evaluation of 4-substituted semicarbazone of levulinic acid for anticonvulsant activity. J Zhejiang Univ Sci;6:617-621.
7. Sathisha M.P., Revankar V.K., Pai K.S.R. (2008) Synthesis, structure, electrochemistry, and spectral characterization of bis-Isatinthiocarbohydrazone metal complexes and their antitumor activity against ehrlich ascites carcinoma in swiss albino mice. Met-Based Drugs;1:1-11.
8. Verma K., Pandeya S.N., Singh U.K., Gupta S., Prashant P., Anurag, Gautam B. (2009) Synthesis and pharmacological activity of some substituted menthonesemicarbazone and thiosemicarbazone derivatives. I J Pharma Sci Nanotech;1:357-362.
9. Cerchiaro G., Ferreira A.M. (2006) Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents. J Braz Chem Soc;17:1473-1485.
10. Deindorfer P., Geiger T., Schollmeyer D., Ye J.H., Zentel R. (2006) Semicarbazides as gel forming agents for common solvents and liquid crystals. J Mater Chem;16:351-388.
11. Yogeeswari P., Sriram D., Veene V., Kavya R., Rakhra K., Ragavendran V.J., Mehta S., Thirumurugan R., Stables J.P. (2005) Synthesis of aryl semicarbazones as potential anticonvulsant agents. Biomed Pharmacother;59:51-55.
12. Scholl S., Koch A., Henning D., Kleinpeter E. (1999) The influence of structure and lipophilicity of hydantoin derivatives on anticonvulsant activity. Struct Chem;10:355-366.
13. Malik F., Hasan M., Khan K.M., Perveen S., Snatzke G., Duddeck H., Voelter W. (1995) Syntheses and CD studies of optically active substituted 1, 3, 4, 5-tetrahydro-2H-1, 5-benzodiazepin-2-ones. Liebigs Ann;10:1861-1869.
14. Ansari F.L., Nazir S., Noureen S., Mirza B. (2005) Combinatorial synthesis and antibacterial studies on an indexed chalcone library. Chem Biodiv;2:1656-1664.
15. Ahmad M.S., Hussain M., Ali S., Qayyum M., Mirza B. (2008) Di- and triorganotin (IV) esters of 3, 4-methylenedioxyphenylpropenoic acid: synthesis, spectroscopic characterization and biological screening of antimicrobial, cytotoxic and antitumor activities. Chem Biol Drug Des;71:568-576.
16. Ullah A., Ansari F.L., Haq I., Nazir S., Mirza B. (2007) Combinatorial synthesis and antitumor studies on aryl and heteroaryl chalcone library using positional scanning method. Chem Biodiv;4:203-214.
17. Nawaz H., Akhter Z., Yameen S., Siddiqi H.M., Mirza B., Rifat A. (2009) Synthesis and biological evaluations of some Schiff-base esters of ferrocenyl and simple aniline. J Organomet Chem;694:2198-2203.
18. Kirilmis C., Koca M., Çukurovali A., Ahmedzade M., Kazaz C. (2005) Synthesis, reactivity and biological activity of novel bisbenzofuran-2-yl-methanone derivatives. Molecules;10:1399-1408.
19. Hussain M., Hanif M., Ali S., Shahzadi S., Ahmad M.S., Mirza B., Evans H.S. (2009) Synthesis and coordination chemistry of organotin (IV) complexes of 2, 3-methylenedioxyphenylpropenoic acid. J Coord Chem;62:2229-2238.
20. Savini L., Chiasserini L., Travagli V., Pellerano C., Novellino E., Cosentino S., Pisano M.B. (2004) New α-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity. Eur J Med Chem;39:113-122.
21. Dong-Seong C., Sang-Jin K., Jung M.Y. (2001) Inhibitory activiyt of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c. Biosci Biotechnol Biochem;65:452-455.
22. Lee B.M., Park K.K. (2003) Beneficial and adverse effects of chemopreventive agents. Mutat Res;523-524:265-278.
23. Fukumoto L.R., Mazza G. (2000) Assessing antioxidant and prooxidant activities of phenolic compounds. J Agric Food Chem;48:3597-3604.
24. Sammaiah G., Sarangapani M. (2008) Synthesis and characterization of biologically significant 3-(2-Oxo-1, 2, dihydroindol-3-ylideneamino)-3Hbenzo[d][1, 2, 3]triazin-4-ones. Asian J Chem;20:282-286.
25. Wan L.S.C., Hwang C.L. (1968) Studies on the effect of gallate on the oxidation of aldehydes dispersed in cetomacrogol solutions. J Pharm Sci;58:262-264.
26. Ansari F.L., Sumaira U., Latif H., Talat M., Nawaz S.A., Lodhi M.A., Khan S.N., Shaheen F., Chaudhry M.I., Rahman A. (2005) Synthesis and biological activities of chaconne and benzothioapine derivatives: promising new free radical scavengers, and cholinesterases, urease, and alpha-glucosidase inhibitors. Chem Biodiv;4:487-496.
27. Krings U., Johansson L., Zorn H., Berger R.F. (2006) In vitro DNA-protective activity of roasted wheat germ and fractions thereof. Food Chem;97:712-718.