Evaluation of anti-diabetic activity and toxic potential of lycium shawii in animal models

Journal of Medicinal Plants Research

Volumn 5, Issue 15, 2011, Pages 3387-3395

  Sher, Hassan ^a   Alyemeni, Mohammed N ^b  

^a University of Swat   (Pakistan)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Blood glucose lowering potential; Lycium shawii; Streptozotocin diabetes; Toxicity biochemical and hematological effects

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; LYCIUM SHAWII EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HISTOPATHOLOGY; HYPOGLYCEMIA; LYCIUM; LYCIUM SHAWII; MALE; MOUSE; NONHUMAN; RAT; SEMEN ANALYSIS; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; TOXICITY TESTING;

ANIMALIA; LYCIUM SHAWII; MUS; RATTUS;

EID: 84860411437     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Alyemeni MN, Basahy AY, Sher H (2011). Physico-chemical analysis and mineral composition of some sesame seeds (Sesamum indicum L.) grown in the Gizan area of Saudi Arabia. J. Med. Plants Res., 5(2): 270-274.
2. Akthar MS, Iqbal J (1991). Evaluation of the hypoglycemic effect of Achyranthus aspera in normal and diabetic rabbits. J. Ethanopharmacol., 31: 49-57.
3. Al ARM, Barrett DA, Shah AH (2005). Effects of chronic treatment with ethanolic extract of Teucrium polium in mice''. J. Herb Spices Med. Plants, 11: 27-36.
4. Al MNM, Abbas FA, Ahmad MS, Mossa JS, El FFS (2000). Labdane diterpenes from Otostegia fruticosa. Phytochem., 54(8): 771-775.
5. Aslan M, Orhan DD, Sezik E, Yesilada E (2007). In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum, capitulums in streptozotocin-induced diabetic rats. J. Ethnopharmacol., 109: 54-59.
6. Ayatollahi SA, Kobarfard F, Asgarpanah J, Rahmati RM, Fanai G, Choudhary IM (2009). Diterpenoids of Otostegia persica (Burm.) Boiss. Daru, 17(4): 290-293.
7. Demetzos C, Dimas K, Hatziantoniou S, Anastasaki T, Angelopoulou D (2001). Cytotoxic and anti-inflammatory activity of labdane and cisclerodane type diterpenes. Planta Med., 67(7): 614-618.
8. Ebrahimpoor MR, Khaksar Z, Noorafshan A (2009). Antidiabetic effect of Otostegia persica oral extract on streptozotocin-diabetic rats. Res. J. Biol. Sci., 4(12): 1227-1229.
9. Gbolade AA (2009). Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria. J. Ethnopharmacol., 121: 135-139.
10. Gholamhoseinian A, Fallah H, Sharifi FF, Mirtajaddini M (2008). The inhibitory effect of some Iranian plant extracts on the alpha glucosidase. Iranian J. Basic Med. Sci., 11(1): 1-9.
11. Han C, Hui Q, Wang Y (2008). Hypoglycemic activity of saponins fraction extracted from Mamordica charantia in PEG/salt aqueous two-phase systems. Nat. Prod. Res., 229(13): 1112-1119.
12. Iraj H, Vida R, Sara R, Afsaneh A (2009). Chronic complications of diabetes mellitus in newly diagnosed patients. Int. J. Diabetes Mellit., 4: 34-37.
13. Jassbi AR (2006). Chemistry and biological activity of secondary metabolites in Euphorbia from Iran. Phytochem., 67(18): 1977-1984.
14. Jia W, Gao W, Tang L (2003). Antidiabetic herbal drugs officially approved in China: a review. Pytother. Res., 17: 1127-1134.
15. Karu N, Reifen R, Kerem Z (2007). Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J. Agric. Food Chem., 55(8): 2824-2828.
16. Kenjiro T, Yuji M, Kouta T, Tomoko M (2006). Inhibition of alpha glucosidase and alpha amylase by flavonoids. J. Nutr. Sci. Vitaminol., 52(2): 149-153.
17. Khiyami M, Noura AF, Basel B, Sher H (2011). Food borne pathogen contamination in minimally processed vegetable salads in Riyadh, Saudi Arabia. J. Med. Plants Res., 5(3): 444-451.
18. Malviya N, Jain S, Malviya S (2010). Antidiabetic potential of medicinal plants. Acta Pol. Pharm. Drug Res., 67(2): 113-118.
19. Misra M (2009). Opportunities for the exploration, investigation and utilization for biological activity of novel medicinal plants. J. Med. Plants Res., 3(11): 1-7.
20. Ntambi JM, Miyazaki M (2003). Recent insights into stearoyl-CoA desaturase-1. Curr. Opin. Lipidol., 14: 255-261.
21. Park MW, Ha J, Chung SH (2008). 20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK. Biol. Pharm. Bull., 31(4): 748-751.
22. Prasad SK, Kulshreshtha A, Qureshi TN (2009). Antidiabetic activity of some herbal plants in streptozotocin induced diabetic albino rats. Pak. J. Nutr., 8(5): 551-557.
23. Qi LW, Liu EH, Chu C, Peng YB, Cai HX, Li P (2010). Anti-diabetic agents from natural products - an update from 2004-2009. Curr. Top. Med. Chem., 10(4): 434-457.
24. Qureshi S, Al YMA, Mossa JS, Tariq M, Ageel AM, Shah AH (1990). Preliminary toxicity studies on ethanol extract of the aerial parts of Artemisia abyssinica and A. inculta. J. Ethnopharmacol., 28: 157-162.
25. Premurkumar G, Sankaranarayanan R, Jeeva S, Rajarathinam K (2011). Cytokinin induce shoot regeneration and flowering of Scoparia dulics L (Scrophularaceae)- an ethnomedicinal herb. APJTB. 2011. P. 169-172
26. Rauter AP, Martins A, Lopes R, Ferreira J, Serralheiro LM, Araujo ME, Borges C, Sila FV, Coulart M, Thomas OJ, Rodriques JA, Edwards E, Noronha JP, Pinto R, Mota FH (2009). Bioactivity studies and chemical profile of the antidiabetic plant Genista ternera. J. Ethnopharmcol., 122(2): 384-393.
27. Shah AH, Qureshi S, Ageel AM (1991). Toxicity studies on Foeniculum vulgare fruits and Ruta chelapensis aerial parts. J. Ethnopharmacol., 34: 167-172.
28. Shu XS, Lv JH, Tao J, Li GM, Li HD, Ma N (2009). Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats. J. Ethnopharmacol., 124(3): 539-543.
29. Singh S, Gupta SK, Sabir G, Gupta MK, Seth PK (2009). A data base for anti-diabetic plants with clinical/experimental trials. Bioinformation, 4(6): 973-268.
30. Tahraoui A, El HJ, Israili ZH, Lyoussi B (2007). Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J. Ethnopharmacol., 110: 105-117.
31. Tanira MOM, Ageel AM, Tariq M, Mohsin A, Shah AH (1988). Evaluation of some pharmacological, microbiological and physical properties of Zizyphus spina-christi. Int. J. Pharmacogn. (IJCDR), 26: 56-60.
32. Trovato A, Forestie RI, Lauk L, Barbera R, Monforte MT, Galati EM (1993). Hypoglycemic activity of different extracts of Olea europaea L. in the rats. Plant Med. Phytother., 26: 300-308.
33. WHO (2000). www.who.int/diabetes/facts/world-figures (World Health Organization, Switzerland).
34. Widharna RM, Soemardji AA, Wirasutisna KR, Kardono LBS (2010). Anti diabetes mellitus activity in vivo of ethanolic extract and ethyl acetate fraction of Euphorbia hirta L. Herb. Int. J. Pharmacol., 6: 231-240.