Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin α vβ 6

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5480-5489

  Li, Shunzi ^a   Gray, Bethany Powell ^a   McGuire, Michael J ^a   Brown, Kathlynn C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Drug delivery; Lung cancer; Paclitaxel; Peptide

Indexed keywords

2' MALEIMIDO PACLITAXEL; ALPHAVBETA5 INTEGRIN; H2009 1 PEPTIDE; PACLITAXEL; PACLITAXEL DERIVATIVE; PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL VIABILITY; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MONOTHERAPY; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TREATMENT RESPONSE; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLOW CYTOMETRY; HUMANS; INTEGRINS; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR CONFORMATION; PACLITAXEL; PEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860407814     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.046     Document Type: Article

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