Single-drug multiligand conjugates: Synthesis and preliminary cytotoxicity evaluation of a paclitaxel-dipeptide "scorpion" molecule

Bioconjugate Chemistry

Volumn 17, Issue 3, 2006, Pages 565-570

  Safavy, Ahmad ^a,d   Raisch, Kevin P ^a   Matusiak, Damien ^b   Bhatnagar, Saloni ^a   Helson, Lawrence ^c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c TAPESTRY Pharmaceuticals   (United States)

^d The University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAYESIAN NETWORKS; CELL CULTURE; CELL MEMBRANES; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DIAGNOSIS; LIGANDS; SOLUBILITY; SYNTHESIS (CHEMICAL); TARGETED DRUG DELIVERY;

CELL SURFACE RECEPTORS; CYTOTOXIC ACTIVITIES; DI-PEPTIDES; DRUG-PEPTIDES; LOW WATER; PACLITAXEL; PROPERTY; RANDOM SCREENING; SYNTHESISED; WATER SOLUBILITIES;

PEPTIDES;

ALANINE; AMPHIBIAN PROTEIN; BOMBESIN DERIVATIVE; CELL SURFACE RECEPTOR; DIPEPTIDE; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; GLYCINE; HISTIDINE; LEUCINE; LIGAND; MACROGOL DERIVATIVE; METHIONINE; PACLITAXEL DERIVATIVE; POLYMER; TRYPTOPHAN; TYROSINE; VALINE;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; LIPOPHILICITY; MODEL; SOLUBILITY; STEREOSPECIFICITY;

AMPHIBIA; SCORPIONES;

EID: 33646909900     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc050224c     Document Type: Article

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