Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells

Molecular and Cellular Endocrinology

Volumn 344, Issue 1-2, 2011, Pages 41-50

  Tsukamoto, Naoko ^a   Otsuka, Fumio ^a   Miyoshi, Tomoko ^a   Inagaki, Kenichi ^a   Nakamura, Eri ^a   Terasaka, Tomohiro ^a   Takeda, Masaya ^a   Ogura, Toshio ^a   Iwasaki, Yasumasa ^b   Makino, Hirofumi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Adrenocorticotropin; Bone morphogenetic protein; Corticotrope; Corticotropin releasing hormone; Growth hormone releasing peptide; Mitogen activated protein kinase

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CORTICOTROPIN; CYCLIC AMP; GROWTH HORMONE; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ACTH SECRETING CELL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN RELEASE; HUMAN; HUMAN CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL LINE; CORTICOTROPHS; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; FEEDBACK, PHYSIOLOGICAL; GENES, REPORTER; HUMANS; LUCIFERASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGOPEPTIDES; PHOSPHORYLATION; PITUITARY GLAND; PRO-OPIOMELANOCORTIN; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84860397544     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.06.016     Document Type: Article

References (43)

1. Aoki Y., Iwasaki Y., Katahira M., Oiso Y., Saito H. Regulation of the rat proopiomelanocortin gene expression in AtT-20 cells I: effects of the common secretagogues. Endocrinology 1997, 138:1923-1929.
2. Arvat E., di Vito L., Maccagno B., Broglio F., Boghen M.F., Deghenghi R., Camanni F., Ghigo E. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Peptides 1997, 18:885-891.
3. Arzt E., Holsboer F. CRF signaling: molecular specificity for drug targeting in the CNS. Trends Pharmacol. Sci. 2006, 27:531-538.
4. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Fujimiya M., Katsuura G., Makino S., Fujino M.A., Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 2001, 74:143-147.
5. Bowers C.Y. GH releasing peptides-structure and kinetics. J. Pediatr. Endocrinol. 1993, 6:21-31.
6. Brar B.K., Chen A., Perrin M.H., Vale W. Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Endocrinology 2004, 145:1718-1729.
7. Cuny G.D., Yu P.B., Laha J.K., Xing X., Liu J.F., Lai C.S., Deng D.Y., Sachidanandan C., Bloch K.D., Peterson R.T. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg. Med. Chem. Lett. 2008, 18:4388-4392.
8. Frieboes R.M., Murck H., Maier P., Schier T., Holsboer F., Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology 1995, 61:584-589.
9. Gazzerro E., Canalis E. Bone morphogenetic proteins and their antagonists. Rev. Endocr. Metab. Disord. 2006, 7:51-65.
10. Ghigo E., Arvat E., Broglio F., Giordano R., Gianotti L., Muccioli G., Papotti M., Graziani A., Bisi G., Deghenghi R., Camanni F. Endocrine and non-endocrine activities of growth hormone secretagogues in humans. Horm. Res. 1999, 51(Suppl. 3):9-15.
11. Giacomini D., Paez-Pereda M., Stalla J., Stalla G.K., Arzt E. Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter. Mol. Endocrinol. 2009, 23:1102-1114.
12. Giacomini D., Paez-Pereda M., Theodoropoulou M., Gerez J., Nagashima A.C., Chervin A., Berner S., Labeur M., Refojo D., Renner U., Stalla G.K., Arzt E. Bone morphogenetic protein-4 control of pituitary pathophysiology. Front Horm. Res. 2006, 35:22-31.
13. Giacomini D., Paez-Pereda M., Theodoropoulou M., Labeur M., Refojo D., Gerez J., Chervin A., Berner S., Losa M., Buchfelder M., Renner U., Stalla G.K., Arzt E. Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action. Endocrinology 2006, 147:247-256.
14. Hirotani C., Oki Y., Ukai K., Okuno T., Kurasaki S., Ohyama T., Doi N., Sasaki K., Ase K. ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF. Naunyn Schmiedebergs Arch. Pharmacol. 2005, 371:54-60.
15. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K.K., McKee K.K., Pong S.S., Chaung L.Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M., Sirinathsinghji D.J., Dean D.C., Melillo D.G., Patchett A.A., Nargund R., Griffin P.R., DeMartino J.A., Gupta S.K., Schaeffer J.M., Smith R.G., Van der Ploeg L.H. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996, 273:974-977.
16. Huang H.-J., Wu J.C., Su P., Zhirnov O., Miller W.L. A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone. Endocrinology 2001, 142:2275-2283.
17. Kageyama K., Kushibiki M., Hanada K., Sakihara S., Yasujima M., Suda T. Growth hormone-releasing peptide-2 stimulates secretion and synthesis of adrenocorticotropic hormone in mouse pituitary. Regul. Pept. 2009, 158:116-120.
18. Kamoi K., Minagawa S., Kimura K., Ishizawa M., Ohara N., Uemura Y., Tsuchiya J. GH-releasing peptide-2 does not stimulate arginine vasopressin secretion in healthy men. Endocr. J. 2010, 57:175-180.
19. Kimura T., Shimatsu A., Arimura H., Mori H., Tokitou A., Fukudome M., Nakazaki M., Tei C. Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2. Endocr. J. 2010, 57:639-644.
20. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
21. Korbonits M., Kaltsas G., Perry L.A., Putignano P., Grossman A.B., Besser G.M., Trainer P.J. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. J. Clin. Endocrinol. Metab. 1999, 84:2489-2495.
22. Korbonits M., Little J.A., Forsling M.L., Tringali G., Costa A., Navarra P., Trainer P.J., Grossman A.B. The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants. J. Neuroendocrinol. 1999, 11:521-528.
23. Kovalovsky D., Refojo D., Liberman A.C., Hochbaum D., Pereda M.P., Coso O.A., Stalla G.K., Holsboer F., Arzt E. Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol. Endocrinol. 2002, 16:1638-1651.
24. Luini A., Lewis D., Guild S., Corda D., Axelrod J. Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells. Proc. Natl. Acad. Sci. USA 1985, 82:8034-8038.
25. Machado M.C., Valeria de Sa S., Correa-Giannella M.L., Giorgi R.R., Pereira M.A., Cescato V.A., Giannella-Neto D., Salgado L.R. Association between tumoral GH-releasing peptide receptor type 1a mRNA expression and in vivo response to GH-releasing peptide-6 in ACTH-dependent Cushing's syndrome patients. Eur. J. Endocrinol. 2008, 158:605-613.
26. Matsumoto Y., Otsuka F., Takano M., Mukai T., Yamanaka R., Takeda M., Miyoshi T., Inagaki K., Sada K.E., Makino H. Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-alpha in C2C12 cells. Mol. Cell Endocrinol. 2010, 325:118-127.
27. Miyoshi T., Otsuka F., Otani H., Inagaki K., Goto J., Yamashita M., Ogura T., Iwasaki Y., Makino H. Involvement of bone morphogenetic protein-4 in GH regulation by octreotide and bromocriptine in rat pituitary GH3 cells. J. Endocrinol. 2008, 197:159-169.
28. Moore R.K., Otsuka F., Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J. Biol. Chem. 2003, 278:304-310.
29. Otsuka F. Multiple endocrine regulation by bone morphogenetic protein system. Endocr. J. 2010, 57:3-14.
30. Otsuka F., Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology 2002, 143:4938-4941.
31. Paez-Pereda M., Giacomini D., Refojo D., Nagashima A.C., Hopfner U., Grubler Y., Chervin A., Goldberg V., Goya R., Hentges S.T., Low M.J., Holsboer F., Stalla G.K., Arzt E. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Proc. Natl. Acad. Sci. USA 2003, 100:1034-1039.
32. Perrin M.H., Vale W.W. Corticotropin releasing factor receptors and their ligand family. Ann. N Y Acad. Sci. 1999, 885:312-328.
33. Raun K., Hansen B.S., Johansen N.L., Thogersen H., Madsen K., Ankersen M., Andersen P.H. Ipamorelin, the first selective growth hormone secretagogue. Eur. J. Endocrinol. 1998, 139:552-561.
34. Rossant C.J., Pinnock R.D., Hughes J., Hall M.D., McNulty S. Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase. Endocrinology 1999, 140:1525-1536.
35. Schecterson L.C., McKnight G.S. Role of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in hormone-stimulated beta-endorphin secretion in AtT20 cells. Mol. Endocrinol. 1991, 5:170-178.
36. Scully K.M., Rosenfeld M.G. Pituitary development: regulatory codes in mammalian organogenesis. Science 2002, 295:2231-2235.
37. Shimasaki S., Moore R.K., Otsuka F., Erickson G.F. The bone morphogenetic protein system in mammalian reproduction. Endocr. Rev. 2004, 25:72-101.
38. Smith R.G., Van der Ploeg L.H., Howard A.D., Feighner S.D., Cheng K., Hickey G.J., Wyvratt M.J., Fisher M.H., Nargund R.P., Patchett A.A. Peptidomimetic regulation of growth hormone secretion. Endocr. Rev. 1997, 18:621-645.
39. Takeda M., Otsuka F., Suzuki J., Kishida M., Ogura T., Tamiya T., Makino H. Involvement of activin/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas. Biochem. Biophys. Res. Commun. 2003, 306:812-818.
40. Thomas G.B., Fairhall K.M., Robinson I.C. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 1997, 138:1585-1591.
41. Tsukamoto N., Otsuka F., Miyoshi T., Inagaki K., Nakamura E., Suzuki J., Ogura T., Iwasaki Y., Makino H. Activities of bone morphogenetic proteins in prolactin regulation by somatostatin analogs in rat pituitary GH3 cells. Mol. Cell Endocrinol. 2011, 332:163-169.
42. Tsukamoto N., Otsuka F., Miyoshi T., Yamanaka R., Inagaki K., Yamashita M., Otani H., Takeda M., Suzuki J., Ogura T., Iwasaki Y., Makino H. Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: involvement of up-regulation of BMP receptor signaling by somatostatin analogs. Endocrinology 2010, 151:1129-1141.
43. Yu P.B., Hong C.C., Sachidanandan C., Babitt J.L., Deng D.Y., Hoyng S.A., Lin H.Y., Bloch K.D., Peterson R.T. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2008, 4:33-41.