A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2275-2283

  Huang, Huey Jing ^a   Wu, Joyce C ^a   Su, Pei ^a   Zhirnov, Oksana ^a   Miller, William L ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 6; FOLLITROPIN; MESSENGER RNA; MYELOPID; NEUTRALIZING ANTIBODY; OSTEOGENIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FOLLITROPIN RELEASE; HORMONE INHIBITION; HORMONE SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0035009383     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8159     Document Type: Article

References (31)

1. 1. Kumar TR, Wang Y, Lu N, Matzuk MM 1997 Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 15:201-204
2. 2. Wozney JM 1989 Bone morphogenetic proteins. Prog Growth Factor Res 1:267-280
3. 3. Kawabata M, Imamura T, Miyazono K 1998 Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 9:49-61
4. 4. Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF 1999 A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci USA 96:7282-7287
5. 5. Massague J 1998 TGF-β signal transduction. Annu Rev Biochem 67:753-791
6. 6. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R 1986 Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321:779-782
7. 7. Weiss J, Guendner MJ, Halvorson LM, Jameson JL 1995 Transcriptional activation of the follicle-stimulating hormone β-subunit gene by activin. Endocrinology 136:1885-1891
8. 8. Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL 1993 Identification of human activin and TGFβ type 1 receptors that form heteromeric kinase complexes with type II receptors. Cell 75:671-680
9. 9. Carcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massague J 1994 Type 1 receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol Cell Biol 14:3810-3821
10. 10. Mathews LS, Vale WW 1991 Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982
11. 11. Mathews LS, Vale WW, Kintner CR 1992 Cloning of a second type of activin receptor and functional characterization in Xenopus embryos. Science 255:1702-1705
12. 12. Carroll RS, Corrigan AZ, Gharib SD, Vale W, Chin WW 1989 Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels. Mol Endocrinol 3:1969-1976
13. 13. Roberts V, Meunier H, Vaughan J, Rivier J, Rivier C, Vale W, Sawchenko P 1989 Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology 124:552-554
14. 14. Corrigan AZ, Bilezikjian LM, Carroll RS, Bald LN, Schmelzer CH, Fendly BM, Mason AJ, Chin WW, Schwall RH, Vale W 1991 Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology 128:1682-1684
15. B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev 8:414-427
16. 16. Yamashita H, ten Dijke P, Huylebroeck D, Sampath TK, Andries M, Smith JC, Heldin CH, Miyazono K 1995 Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol 130:217-226
17. 17. DePaolo LV, Shimonaka M, Schwall RH, Ling N 1991 In vivo comparison of the follicle-stimulating hormone-suppressing activity of follistatin and inhibin in ovariectomized rats. Endocrinology 128:668-674
18. 18. Kogawa K, Nakamura T, Sugino K, Takio K, Titani K, Sugino H 1991 Activin-binding protein is present in pituitary. Endocrinology 128:1434-1440
19. 19. Iemura S, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, Sugino H, Ueno N 1998 Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci USA 95:9337-9342
20. 19a. Huang HJ, Sebastian J, Strahl BD, Wu JC, Miller WL 2001 The promoter for the ovine follicle-stimulating hormone-β gene (FSHβ) confers FSHβ-like expression on luciferase in transgenic mice: regulatory studies in vivo and in vitro. Endocrinology 142:2260-2266
21. 19b. Huang HJ, Sebastian J, Strahl BD, Wu JC, Miller WL 2001 Transcriptional regulation of the ovine follicle-stimulating hormone-β gene by activin and gonadotropin-releasing hormone (GnRH): involvement of two proximal activator protein-1 sites for GnRH-stimulation. Endocrinology 142:2267-2274
22. 20. Strahl BD, Huang HJ, Pedersen NR, Wu JC, Ghosh BR, Miller WL 1997 Two proximal activating protein-1-binding sites are sufficient to stimulate transcription of the ovine follicle-stimulating hormone-β gene. Endocrinology 138:2621-2631
23. 21. Schneyer AL, Rzueidlo DA, Sluss PM, Crowley Jr WF 1994 Characterization of unique binding kinetics of follistatin and activin or inhibin in serum. Endocrinology 135:667-674
24. 22. Blessing M, Schirmacher P, Kaiser S 1996 Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol 135:227-239
25. 23. Hashimoto O, Nakamura T, Shoji H, Shimasaki S, Hayashi Y, Sugino H 1997 A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J Biol Chem 272:13835-13842
26. 24. Graham KE, Nusser KD, Low MJ 1999 LβT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to active A. J Endocrinol 162:R1-R5
27. 25. Shikone T, Matzuk MM, Perlas E, Finegold MJ, Lewis KA, Vale W, Bradley A, Hsueh AJ 1994 Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-α and p53-deficient mice: the role of activin as an autocrine growth factor. Mol Endocrinol 8:983-995
28. 26. Whitfield GK, Miller WL 1984 Biosynthesis and secretion of follicle-stimulating hormone β-subunit from ovine pituitary cultures: effect of 17β-estradiol treatment. Endocrinology 115:154-159
29. 27. Aono A, Hazama M, Notoya K, Taketomi S, Yamasaki H, Tsukuda R, Sasaki S, Fujisawa Y 1995 Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer. Biochem Biophys Res Commun 210:670-677
30. 28. Israel DI, Nove J, Kerns KM, Kaufman RJ, Rosen V, Cox KA, Wozney JM 1996 Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors 13:291-300
31. 29. Vaughan JM, Rivier J, Corrigan AZ, McClintock R, Campen CA, Jolley D, Voglmayr JK, Bardin CW, Rivier C, Vale W 1989 Detection and purification of inhibin using antisera generated against synthetic peptide fragments. Methods Enzymol 168:588-617