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Volumn 25, Issue 7, 2011, Pages 990-999

Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats

Author keywords

Smooth muscle actin; Hepatic fibrosis; Hepatic stellate cell; Inflammation; Nuclear factor B; Transforming growth factor 1; Triptolide; Tumor necrosis factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; COLLAGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860396737     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3381     Document Type: Article
Times cited : (20)

References (61)
  • 1
    • 0030796417 scopus 로고    scopus 로고
    • Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
    • Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, Schuppan D. 1997. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology 26:643-649. (Pubitemid 27392355)
    • (1997) Hepatology , vol.26 , Issue.3 , pp. 643-649
    • Boigk, G.1    Stroedter, L.2    Herbst, H.3    Waldschmidt, J.4    Riecken, E.O.5    Schuppan, D.6
  • 3
    • 0028871382 scopus 로고
    • Tumor necrosis factor-alpha and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride
    • Chamulitrat W, Blazka ME, Jordan SJ, Luster MI, Mason RP. 1995. Tumor necrosis factor-alpha and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride. Life Sci 57:2273-2280.
    • (1995) Life Sci , vol.57 , pp. 2273-2280
    • Chamulitrat, W.1    Blazka, M.E.2    Jordan, S.J.3    Luster, M.I.4    Mason, R.P.5
  • 4
    • 0035978511 scopus 로고    scopus 로고
    • Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines
    • DOI 10.1016/S0378-4274(01)00353-8, PII S0378427401003538
    • Chan EW, Cheng SC, Sin FW, Xie Y. 2001. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol Lett 122:81-87. (Pubitemid 32524060)
    • (2001) Toxicology Letters , vol.122 , Issue.1 , pp. 81-87
    • Wai-Ching Chan, E.1    Chak-Sum Cheng, S.2    Wan-Yee Sin, F.3    Xie, Y.4
  • 5
    • 0034909663 scopus 로고    scopus 로고
    • Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium Wilfordii Hook F
    • Chen BJ. 2001. Triptolide, a novel immunosuppressive and antiinflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 42:253-265. (Pubitemid 32725582)
    • (2001) Leukemia and Lymphoma , vol.42 , Issue.3 , pp. 253-265
    • Chen, B.J.1
  • 6
    • 0034722721 scopus 로고    scopus 로고
    • Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion
    • Chen BJ, Liu C, Cui X, Fidler JM, Chao NJ. 2000. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation 70:1442-1447.
    • (2000) Transplantation , vol.70 , pp. 1442-1447
    • Chen, B.J.1    Liu, C.2    Cui, X.3    Fidler, J.M.4    Chao, N.J.5
  • 7
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • DOI 10.1006/abio.1987.9999
    • Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159. (Pubitemid 17064313)
    • (1987) Analytical Biochemistry , vol.162 , Issue.1 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 33646579586 scopus 로고    scopus 로고
    • Antifibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats
    • Chong LW, Hsu YC, Chiu YT, Yang KC, Huang YT. 2006. Antifibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. J Biomed Sci 13:403-418.
    • (2006) J Biomed Sci , vol.13 , pp. 403-418
    • Chong, L.W.1    Hsu, Y.C.2    Chiu, Y.T.3    Yang, K.C.4    Huang, Y.T.5
  • 9
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis
    • DOI 10.1002/hep.21802
    • Elsharkawy AM, Mann DA. 2007. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46:590-597. (Pubitemid 47344795)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 10
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • Friedman SL. 2008a. Mechanisms of hepatic fibrogenesis. Gastroenterology 134:1655-1669. (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 11
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman SL. 2008b. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88:125-172.
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 12
    • 38549153486 scopus 로고    scopus 로고
    • 4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation
    • DOI 10.1124/mol.107.039818
    • 4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 73:399-409. (Pubitemid 351159210)
    • (2008) Molecular Pharmacology , vol.73 , Issue.2 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 13
    • 0036257518 scopus 로고    scopus 로고
    • Oxidative stress, plant-derived antioxidants and liver fibrosis
    • DOI 10.1055/s-2002-26761
    • Gebhardt R. 2002. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 68:289-296. (Pubitemid 34494036)
    • (2002) Planta Medica , vol.68 , Issue.4 , pp. 289-296
    • Gebhardt, R.1
  • 15
    • 0026653040 scopus 로고
    • Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f
    • Gu WZ, Brandwein SR, Banerjee S. 1992. Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f. J Rheumatol 19:682-688.
    • (1992) J Rheumatol , vol.19 , pp. 682-688
    • Gu, W.Z.1    Brandwein, S.R.2    Banerjee, S.3
  • 16
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • DOI 10.1016/0022-1759(89)90397-9
    • Hansen MB, Nielsen SE, Berg K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210. (Pubitemid 19132276)
    • (1989) Journal of Immunological Methods , vol.119 , Issue.2 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 17
    • 0031596594 scopus 로고    scopus 로고
    • Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor
    • DOI 10.1002/hep.510270514
    • Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA. 1998. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology 27:1285-1295. (Pubitemid 28227855)
    • (1998) Hepatology , vol.27 , Issue.5 , pp. 1285-1295
    • Hellerbrand, C.1    Jobin, C.2    Iimuro, Y.3    Licato, L.4    Balfour Sartor, R.5    Brenner, D.A.6
  • 18
    • 33847367730 scopus 로고    scopus 로고
    • Liver fibrosis: Cellular mechanisms of progression and resolution
    • DOI 10.1042/CS20060242
    • Henderson NC, Iredale JP. 2007. Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci (Lond) 112:265-280. (Pubitemid 46392114)
    • (2007) Clinical Science , vol.112 , Issue.5-6 , pp. 265-280
    • Henderson, N.C.1    Iredale, J.P.2
  • 19
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor kappaB signaling
    • Hoffmann A, Baltimore D. 2006. Circuitry of nuclear factor kappaB signaling. Immunol Rev 210:171-186.
    • (2006) Immunol Rev , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 20
  • 22
    • 17744379154 scopus 로고    scopus 로고
    • Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine- intoxicated rats
    • Hsu YC, Lin YL, Chiu YT, Shiao MS, Lee CY, Huang YT. 2005. Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats. J Biomed Sci 12:185-195.
    • (2005) J Biomed Sci , vol.12 , pp. 185-195
    • Hsu, Y.C.1    Lin, Y.L.2    Chiu, Y.T.3    Shiao, M.S.4    Lee, C.Y.5    Huang, Y.T.6
  • 23
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. 1997. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-1537. (Pubitemid 27520019)
    • (1997) Hepatology , vol.26 , Issue.6 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.3    Kono, H.4    Thurman, R.G.5
  • 24
    • 0023425909 scopus 로고
    • A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat
    • Jezequel AM, Mancini R, Rinaldesi ML, Macarri G, Venturini C, Orlandi F. 1987. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepatol 5:174-181.
    • (1987) J Hepatol , vol.5 , pp. 174-181
    • Jezequel, A.M.1    Mancini, R.2    Rinaldesi, M.L.3    Macarri, G.4    Venturini, C.5    Orlandi, F.6
  • 25
    • 0034843656 scopus 로고    scopus 로고
    • Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen α1(I) and TIMP-1
    • DOI 10.1016/S0168-8278(01)00148-9, PII S0168827801001489
    • Jia JD, Bauer M, Cho JJ et al. 2001. Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1 (I) and TIMP-1. J Hepatol 35:392-398. (Pubitemid 32844194)
    • (2001) Journal of Hepatology , vol.35 , Issue.3 , pp. 392-398
    • Jia, J.-D.1    Bauer, M.2    Cho, J.J.3    Ruehl, M.4    Milani, S.5    Boigk, G.6    Riecken, E.O.7    Schuppan, D.8
  • 26
    • 0028358443 scopus 로고
    • Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome
    • DOI 10.1007/BF00866356
    • Jiang X. 1994. Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome. Pediatr Nephrol 8:343-344. (Pubitemid 24162277)
    • (1994) Pediatric Nephrology , vol.8 , Issue.3 , pp. 343-344
    • Jiang, X.1
  • 27
    • 85047700175 scopus 로고    scopus 로고
    • Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells
    • DOI 10.1038/sj/onc/1204981
    • Jiang XH, Wong BC, Lin MC et al. 2001. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factorkappaB activation in gastric cancer cells. Oncogene 20:8009-8018. (Pubitemid 34001562)
    • (2001) Oncogene , vol.20 , Issue.55 , pp. 8009-8018
    • Jiang, X.-H.1    Wong, B.C.-Y.2    Lin, M.C.-M.3    Zhu, G.-H.4    Kung, H.-F.5    Jiang, S.-H.6    Yang, D.7    Lam, S.-K.8
  • 29
    • 0036023433 scopus 로고    scopus 로고
    • Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells
    • Kiviharju TM, Lecane PS, Sellers RG, Peehl DM. 2002. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 8:2666-2674. (Pubitemid 34856355)
    • (2002) Clinical Cancer Research , vol.8 , Issue.8 , pp. 2666-2674
    • Kiviharju, T.M.1    Lecane, P.S.2    Sellers, R.G.3    Peehl, D.M.4
  • 31
    • 0033623899 scopus 로고    scopus 로고
    • Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cells
    • DOI 10.1016/S0168-8278(00)80159-2
    • Lang A, Schoonhoven R, Tuvia S, Brenner DA, Rippe RA. 2000. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol 33:49-58. (Pubitemid 30418934)
    • (2000) Journal of Hepatology , vol.33 , Issue.1 , pp. 49-58
    • Lang, A.1    Schoonhoven, R.2    Tuvia, S.3    Brenner, D.A.4    Rippe, R.A.5
  • 32
    • 0030052322 scopus 로고    scopus 로고
    • Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C
    • DOI 10.1053/jhep.1996.v23.pm0008591843
    • Larrea E, Garcia N, Qian C, Civeira MP, Prieto J. 1996. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 23:210-217. (Pubitemid 26045936)
    • (1996) Hepatology , vol.23 , Issue.2 , pp. 210-217
    • Larrea, E.1    Garcia, N.2    Qian, C.3    Civeira, M.P.4    Prieto, J.5
  • 33
    • 33646854369 scopus 로고    scopus 로고
    • Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-κB activation
    • DOI 10.1016/j.bbrc.2006.05.024, PII S0006291X06010618
    • Liu Q, Chen T, Chen G et al. 2006. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem Biophys Res Commun 345:1122-1130. (Pubitemid 43776516)
    • (2006) Biochemical and Biophysical Research Communications , vol.345 , Issue.3 , pp. 1122-1130
    • Liu, Q.1    Chen, T.2    Chen, G.3    Li, N.4    Wang, J.5    Ma, P.6    Cao, X.7
  • 34
    • 0022362862 scopus 로고
    • A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections
    • Lopez-De Leon A, Rojkind M. 1985. A simple micromethod for collagen and total protein determination in formalin-fixed paraffinembedded sections. J Histochem Cytochem 33:737-743. (Pubitemid 15237739)
    • (1985) Journal of Histochemistry and Cytochemistry , vol.33 , Issue.8 , pp. 737-743
    • Lopez-De Leon, A.1    Rojkind, M.2
  • 35
    • 65749103808 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatic stellate cells
    • Mann J, Mann DA. 2009. Transcriptional regulation of hepatic stellate cells. Adv Drug Deliv Rev 61:497-512.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 497-512
    • Mann, J.1    Mann, D.A.2
  • 36
    • 43749098070 scopus 로고    scopus 로고
    • NF-kappaB and cancer-identifying targets and mechanisms
    • Naugler WE, Karin M. 2008. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 18:19-26.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 19-26
    • Naugler, W.E.1    Karin, M.2
  • 37
    • 0034810089 scopus 로고    scopus 로고
    • Cytokine receptors and signaling in hepatic stellate cells
    • DOI 10.1055/s-2001-17554
    • Pinzani M, Marra F. 2001. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 21:397-416. (Pubitemid 32923768)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.3 , pp. 397-416
    • Pinzani, M.1    Marra, F.2
  • 38
    • 0020775518 scopus 로고
    • Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus
    • Qin WZ, Zhu GD, Yang SM, Han KY, Wang J. 1983. Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. J Tradit Chin Med 3:131-132.
    • (1983) J Tradit Chin Med , vol.3 , pp. 131-132
    • Qin, W.Z.1    Zhu, G.D.2    Yang, S.M.3    Han, K.Y.4    Wang, J.5
  • 40
    • 0032005753 scopus 로고    scopus 로고
    • Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme- altered lesions in rat liver cirrhosis induced by a choline-deficient L- amino acid-defined diet
    • DOI 10.1016/0168-8278(88)80017-5
    • Sakaida I, Matsumura Y, Akiyama S, Hayashi K, Ishige A, Okita K. 1998. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 28:298-306. (Pubitemid 28116438)
    • (1998) Journal of Hepatology , vol.28 , Issue.2 , pp. 298-306
    • Sakaida, I.1    Matsumura, Y.2    Akiyama, S.3    Hayashi, K.4    Ishige, A.5    Okita, K.6
  • 41
    • 0038578508 scopus 로고    scopus 로고
    • Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    • DOI 10.1016/S0168-8278(03)00094-1
    • Sakaida I, Tsuchiya M, Kawaguchi K, Kimura T, Terai S, Okita K. 2003. Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 38:762-769. (Pubitemid 36613342)
    • (2003) Journal of Hepatology , vol.38 , Issue.6 , pp. 762-769
    • Sakaida, I.1    Tsuchiya, M.2    Kawaguchi, K.3    Kimura, T.4    Terai, S.5    Okita, K.6
  • 42
    • 0026072529 scopus 로고
    • Classification of chronic viral hepatitis: A need for reassessment
    • Scheuer PJ. 1991. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13:372-374.
    • (1991) J Hepatol , vol.13 , pp. 372-374
    • Scheuer, P.J.1
  • 43
    • 0032875149 scopus 로고    scopus 로고
    • Herbal products for liver diseases: A therapeutic challenge for the new millennium
    • DOI 10.1002/hep.510300437
    • Schuppan D, Jia JD, Brinkhaus B, Hahn EG. 1999. Herbal products for liver diseases: a therapeutic challenge for the new millennium. Hepatology 30:1099-1104. (Pubitemid 29458302)
    • (1999) Hepatology , vol.30 , Issue.4 , pp. 1099-1104
    • Schuppan, D.1    Jia, J.I.-D.2    Brinkhaus, B.3    Hahn, E.G.4
  • 44
    • 0034066205 scopus 로고    scopus 로고
    • Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma
    • Shimizu I. 2000. Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. J Gastroenterol Hepatol 15 Suppl: D84-D90. (Pubitemid 30190730)
    • (2000) Journal of Gastroenterology and Hepatology , vol.15 , Issue.SUPPL.
    • Shimizu, I.1
  • 46
    • 0036065039 scopus 로고    scopus 로고
    • Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study
    • DOI 10.1002/art.10411
    • Tao X, Younger J, Fan FZ, Wang B, Lipsky PE. 2002. Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum 46:1735-1743. (Pubitemid 34774504)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.7 , pp. 1735-1743
    • Tao, X.1    Younger, J.2    Fan, F.Z.3    Wang, B.4    Lipsky, P.E.5
  • 47
    • 33749627330 scopus 로고    scopus 로고
    • How to modulate inflammatory cytokines in liver diseases
    • DOI 10.1111/j.1478-3231.2006.01339.x
    • Tilg H, Kaser A, Moschen AR. 2006. How to modulate inflammatory cytokines in liver diseases. Liver Int 26:1029-1039. (Pubitemid 44541743)
    • (2006) Liver International , vol.26 , Issue.9 , pp. 1029-1039
    • Tilg, H.1    Kaser, A.2    Moschen, A.R.3
  • 48
    • 71049180223 scopus 로고    scopus 로고
    • Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats
    • Tsai M-K, Lin Y-L, Huang Y-T. 2010. Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. Toxicol Appl Pharmacol 242:155-164.
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 155-164
    • Tsai, M.-K.1    Lin, Y.-L.2    Huang, Y.-T.3
  • 51
    • 33646355210 scopus 로고    scopus 로고
    • Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide
    • DOI 10.1007/s00109-005-0022-4
    • Wang X, Matta R, Shen G, Nelin LD, Pei D, Liu Y. 2006. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J Mol Med 84:405-415. (Pubitemid 43673615)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.5 , pp. 405-415
    • Wang, X.1    Matta, R.2    Shen, G.3    Nelin, L.D.4    Pei, D.5    Liu, Y.6
  • 52
    • 0032212753 scopus 로고    scopus 로고
    • Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats
    • Wasser S, Ho JM, Ang HK, Tan CE. 1998. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. J Hepatol 29:760-771.
    • (1998) J Hepatol , vol.29 , pp. 760-771
    • Wasser, S.1    Ho, J.M.2    Ang, H.K.3    Tan, C.E.4
  • 53
    • 70349136709 scopus 로고    scopus 로고
    • Inhibitory effects of armepavine against hepatic fibrosis in rats
    • doi: 10.1186/1423-0127-16-78
    • Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT. 2009. Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci 16:78-90. doi: 10.1186/1423-0127-16-78.
    • (2009) J Biomed Sci , vol.16 , pp. 78-90
    • Weng, T.C.1    Shen, C.C.2    Chiu, Y.T.3    Lin, Y.L.4    Kuo, C.D.5    Huang, Y.T.6
  • 54
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • DOI 10.1136/gut.49.4.577
    • Williams EJ, Benyon RC, Trim N et al. 2001. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49:577-583. (Pubitemid 32896990)
    • (2001) Gut , vol.49 , Issue.4 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.P.6    Unemori, E.N.7    Iredale, J.P.8
  • 56
    • 0041425147 scopus 로고    scopus 로고
    • The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response
    • DOI 10.1016/S1567-5769(03)00144-9
    • Wu Y, Wang Y, Zhong C, Li Y, Li X, Sun B. 2003. The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response. Int Immunopharmacol 3:1457-1465. (Pubitemid 37025726)
    • (2003) International Immunopharmacology , vol.3 , Issue.10-11 , pp. 1457-1465
    • Wu, Y.1    Wang, Y.2    Zhong, C.3    Li, Y.4    Li, X.5    Sun, B.6
  • 57
    • 33644874542 scopus 로고    scopus 로고
    • Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage
    • Wu Y, Cui J, Bao X et al. 2006. Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int J Mol Med 17:141-150.
    • (2006) Int J Mol Med , vol.17 , pp. 141-150
    • Wu, Y.1    Cui, J.2    Bao, X.3
  • 58
    • 33645743816 scopus 로고    scopus 로고
    • Inhibitory effects of triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retroocular fibroblasts derived from patients with Graves' ophthalmopathy
    • Yan SX, Wang Y 2006. Inhibitory effects of triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retroocular fibroblasts derived from patients with Graves' ophthalmopathy. Clin Exp Ophthalmol 34:265-271.
    • (2006) Clin Exp Ophthalmol , vol.34 , pp. 265-271
    • Yan, S.X.1    Wang, Y.2
  • 59
    • 0141576565 scopus 로고    scopus 로고
    • Triptolide inhibits the growth and metastasis of solid tumors
    • Yang S, Chen J, Guo Z et al. 2003. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2:65-72.
    • (2003) Mol Cancer Ther , vol.2 , pp. 65-72
    • Yang, S.1    Chen, J.2    Guo, Z.3
  • 60
    • 8444220061 scopus 로고    scopus 로고
    • Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells
    • DOI 10.1016/j.leukres.2004.05.014, PII S0145212604002188
    • Yinjun L, Jie J, Yungui W. 2005. Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells. Leuk Res 29:99-105. (Pubitemid 39487915)
    • (2005) Leukemia Research , vol.29 , Issue.1 , pp. 99-105
    • Yinjun, L.1    Jie, J.2    Yungui, W.3


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