Synthesis and in vivo evaluation of [O-methyl- 11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl) benzenesulfonamide as an imaging probe for 5-HT 6 receptors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 17, 2011, Pages 5255-5259

  Liu, Fei ^a   Majo, Vattoly J ^a   Prabhakaran, Jaya ^a   Milak, Matthew S ^a,b   John Mann, J ^a,b,c   Parsey, Ramin V ^a,b   Dileep Kumar, J S ^a,b  

^a NewYork Presbyterian Hospital   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Brain; Carbon 11; PET; Radiotracer; Serotonin

Indexed keywords

CARBON 11; DRUG METABOLITE; N (3,5 DICHLORO 2 METHOXYPHENYL) 4 METHOXY 3 (1 PIPERAZINYL)BENZENESULFONAMIDE; N (3,5 DICHLORO 2 METHOXYPHENYL) 4 METHOXY 3 (1 PIPERAZINYL)BENZENESULFONAMIDE C 11; SEROTONIN 6 RECEPTOR; TRACER; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANTERIOR CINGULATE; ARTICLE; BABOON; BRAIN; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; HIPPOCAMPUS; IN VIVO STUDY; ISOTOPE LABELING; MALE; METHYLATION; NONHUMAN; PARAHIPPOCAMPAL GYRUS; PARIETAL CORTEX; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; QUANTITATIVE ANALYSIS; RADIOACTIVITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPORAL CORTEX;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; ISOTOPE LABELING; PAPIO; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONAMIDES; TISSUE DISTRIBUTION;

PAPIO;

EID: 84860390595     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.090     Document Type: Article

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