Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering

Tissue Engineering

Volumn 13, Issue 3, 2007, Pages 435-445

  Xie, Chao ^a   Reynolds, David ^a   Awad, Hani ^a   Rubery, Paul T ^a   Pelled, Gadi ^b   Gazit, Dan ^b   Guldberg, Robert E ^c   Schwarz, Edward M ^a   O'Keefe, Regis J ^a   Zhang, Xinping ^a,d  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; CELL CULTURE; GENETIC ENGINEERING; GRAFTS; ORGANIC COATINGS; TISSUE ENGINEERING;

ALLOGRAFTS; AUTOGRAFTS; BONE TISSUE ENGINEERING; MESENCHYMAL STEM CELLS;

BONE;

BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE ALLOGRAFT; BONE STRENGTH; BONE TISSUE; C57BL 6 MOUSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENCHONDRAL OSSIFICATION; FEMUR; GENETIC ENGINEERING; GENETIC TRANSFECTION; HEALING; HISTOLOGY; ISOGRAFT; MESENCHYMAL STEM CELL; MORPHOLOGY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PERIOSTEUM; PRIORITY JOURNAL; RIGIDITY; SMALL INTESTINE; SUBMUCOSA; TISSUE ENGINEERING;

ANIMALS; BONE AND BONES; BONE TRANSPLANTATION; CATTLE; CELL LINE; GENETIC ENGINEERING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; TISSUE ENGINEERING; TRANSPLANTATION, HOMOLOGOUS;

MURINAE;

EID: 34147192842     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.0182     Document Type: Article

References (37)

1. Burchardt, H. 1983. The biology of bone graft repair. Clin Orthop 28-42.
2. Burchardt, H. 1987. Biology of bone transplantation. Orthop Clin North Am 18:187-196.
3. Lord, C.F., Gebhardt, M.C., Tomford, W.W., and Mankin, H.J. 1988. Infection in bone allografts. Incidence, nature, and treatment. J Bone Joint Surg Am 70:369-376.
4. Berrey, B.H., Jr., Lord, C.F., Gebhardt, M.C., and Mankin, H.J. 1990. Fractures of allografts. Frequency, treatment, and end-results. J Bone Joint Surg Am 72:825-833.
5. Enneking, W.F., and Mindell, E.R. 1991. Observations on massive retrieved human allografts. J Bone Joint Surg Am 73:1123-1142.
6. Hornicek, F.J., Gebhardt, M.C., Tomford, W.W., Sorger, J.I., Zavatta, M., Menzner, J.P., and Mankin, H.J. 2001. Factors affecting nonunion of the allograft-host junction. Clin Orthop 87-98.
7. Enneking, W.F., and Campanacci, D.A. 2001. Retrieved human allografts: a clinicopathological study. J Bone Joint Surg Am 83-A:971-986.
8. Wheeler, D.L., and Enneking, W.F. 2005. Allograft bone decreases in strength in vivo over time. Clin Orthop Relat Res 36-42.
9. Tiyapatanaputi, P., Rubery, P.T., Carmouche, J., Schwarz, E.M., O'Keefe R, J., and Zhang, X. 2004. A novel murine segmental femoral graft model. J Orthop Res 22: 1254-1260.
10. Zhang, X., Xie, C., Lin, A.S., Ito, H., Awad, H., Lieberman, J.R., Rubery, P.T., Schwarz, E.M., O'Keefe, R.J., and Guldberg, R.E. 2005. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res 20:2124-2137.
11. Ito, H., Koefoed, M., Tiyapatanaputi, P., Gromov, K., Goater, J.J., Carmouche, J., Zhang, X., Rubery, P.T., Rabinowitz, J., Samulski, R.J., Nakamura, T., Soballe, K., O'Keefe, R.J., Boyce, B.F., and Schwarz, E.M. 2005. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med 11:291-297.
12. Griffith, L.G., and Naughton, G. 2002. Tissue engineering-current challenges and expanding opportunities. Science 295:1009-1014.
13. Caplan, A.I. 2002. In vivo remodeling. Ann N Y Acad Sci 961:307-308.
14. Bianco, P., and Robey, P.G. 2001. Stem cells in tissue engineering. Nature 414:118-121.
15. Davy, D.T. 1999. Biomechanical issues in bone transplantation. Orthop Clin North Am 30:553-563.
16. Tencer, A., and Johnson, K. 1994. Biomechanics in Orthopaedic Trauma. Philadelphia, JB Lippincott.
17. McLean, V. December 1993. American Association of Tissue Banks. AATP Information Alert Vol. 3.
18. Flick, L.M., Ulrich-Vinther, M., Abuzzahab, F., Zhang, X., Xing, L., Dougall, W., Anderson, D., and Schwarz, E.M. 2001. Effects of RANK blockade on fracture healing. J Orthop Res 21:676-684.
19. Zhang, X., Schwarz, E.M., Young, D.A., Puzas, J.E., Rosier, R.N., and O'Keefe, R.J. 2002. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109: 1405-1415.
20. Brodt, M.D., Ellis, C.B., and Silva, M.J. 1999. Growing C57B1/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res 14:2159-2166.
21. Hasharoni, A., Zilberman, Y., Turgeman, G., Helm, G.A., Liebergall, M., and Gazit, D. 2005. Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2. J Neurosurg Spine 3:47-52.
22. Pelled, G., G. T., Asian, H., Gazit, Z., and Gazit, D. 2002. Mesenchymal stem cells for bone gene therapy and tissue engineering. Curr Pharm Des 8:1917-1928.
23. Moutsatsos, I.K., Turgeman, G., Zhou, S., Kurkalli, B.G., Pelled, G., Tzur, L., Kelley, P., Stumm, N., Mi, S., Muller, R., Zilberman, Y., and Gazit, D. 2001. Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther 3:449-461.
24. Gazit, D., Turgeman, G., Kelley, P., Wang, E., Jalenak, M., Zilberman, Y., and Moutsatsos, I. 1999. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med 1:121-133.
25. Turgeman, G., Pittman, D.D., Muller, R., Kurkalli, B.G., Zhou, S., Pelled, G., Peyser, A., Zilberman, Y., Moutsatsos, I.K., and Gazit, D. 2001. Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med 3:240-251.
26. Bartholomew, A., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K., Patil, S., Hardy, W., Devine, S., Ucker, D., Deans, R., Moseley, A, and Hoffman, R. 2002. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42-48.
27. Tsuchida, H., Hashimoto, J., Crawford, E., Manske, P., and Lou, J. 2003. Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats. J Orthop Res 21: 44-53.
28. Djouad, F., Plence, P., Bony, C., Tropel, P., Apparailly, F., Sany, J., Noel, D., and Jorgensen, C. 2003. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 102:3837-3844.
29. Muschler, G.F., Nakamoto, C., and Griffith, L.G. 2004. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 86-A: 1541-1558.
30. Muschler, G.F., and Midura, R.J. 2002. Connective tissue progenitors: practical concepts for clinical applications. Clin Orthop 66-80.
31. Hodde, J. 2002. Naturally occurring scaffolds for soft tissue repair and regeneration. Tissue Eng 8:295-308.
32. Suckow, M.A., Voytik-Harbin, S.L., Terril, L.A., and Badylak, S.F. 1999. Enhanced bone regeneration using porcine small intestinal submucosa. J Invest Surg 12:277-287.
33. van der Meulen, M.C., Beaupre, G.S., and Carter, D.R. 1993. Mechanobiologic influences in long bone cross-sectional growth. Bone 14:635-642.
34. van der Meulen, M.C., Jepsen, K.J., and Mikic, B. 2001. Understanding bone strength: size isn't everything. Bone 29:101-104.
35. Goldberg, V.M., and Stevenson, S. Bone Transplantation. 1990. In: Evarts, C.M., ed. Surgery of the Musculoskeletal System. New York: Churchill Livingstone, Inc., 115-149.
36. Shefelbine, S.J., Augat, P., Claes, L., and Simon, U. 2005. Trabecular bone fracture healing simulation with finite element analysis and fuzzy logic. J Biomech 38:2440-2450.
37. Shefelbine, S.J., Simon, U., Claes, L., Gold, A., Gabet, Y., Bab, I., Muller, R., and Augat, P. 2005. Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis. Bone 36:480-488.