ANIMAL CELL;
ANIMAL TISSUE;
ARTICLE;
BIOLOGICAL ACTIVITY;
BIOSENSOR;
CONTROLLED STUDY;
DRUG DETERMINATION;
DRUG IDENTIFICATION;
DRUG POTENCY;
DRUG SCREENING;
DYNAMIC MASS REDISTRIBUTION;
MALE;
MEASUREMENT;
NONHUMAN;
RAT;
SIGNAL TRANSDUCTION;
TECHNOLOGY;
Ligand-directed signaling at the beta 3-adrenoceptor produced by 3-(2-ethylphenoxy)-1-[(1,S)- 1, 2,3,4-tetrahydronaphth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists
Sato M, Horinouchi T, Hutchinson DS, Evans BA, Summers RJ: Ligand-directed signaling at the beta 3-adrenoceptor produced by 3-(2-ethylphenoxy)-1-[(1,S)- 1,2,3,4-tetrahydronaphth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists. Mol Pharmacol 2007;72:1359-1368.
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction
Whistler JL, von Zastrow M: Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. J Biol Chem 1999;274:24575-24578.
The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent Mu opioid RWJ-413216
Codd EE, Carson JR, Colburn RW, et al.: The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent Mu opioid RWJ-413216. J Pharmacol Exp Ther 2006;318:1273-1279.
A novel Gbeta gamma -subunit inhibitor selectively modulates mu -opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence
Mathews JL, Smrcka AV, Bidlack JM: A novel Gbeta gamma -subunit inhibitor selectively modulates mu -opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence. J Neurosci 2008;28:12183-12189.
Trafficking of preassembled opioid mu -delta heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists
Hasbi A, Nguyen T, Fan T, et al.: Trafficking of preassembled opioid mu -delta heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists. Biochemistry 2007;46:12997-13009.
A Role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers
Fan T, Varghese G, Nguyen T, Tse R, O'Dowd BF, George SR: A Role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers. J Biol Chem 2005; 280:38478-38488.
Naloxone's pentapeptide binding site on filamin A blocks mu opioid receptor-Gs coupling and CREB activation of acute morphine
Wang H-Y, Burns LH: Naloxone's pentapeptide binding site on filamin A blocks mu opioid receptor-Gs coupling and CREB activation of acute morphine. PLoS One 2009;4:e4282.
High-affinity naloxone binding to filamin A prevents Mu opioid receptor-Gs coupling underlying opioid tolerance and dependence
Wang H-Y, Frankfurt M, Burns LH: High-affinity naloxone binding to filamin A prevents Mu opioid receptor-Gs coupling underlying opioid tolerance and dependence. PLoS One 2008;3:e1554.
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery
Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS: Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol 2004;66:106-112.
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu -opioid receptors
Li L-Y, Chang K-J: The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu -opioid receptors. Mol Pharmacol 1996;50:599-602.
Mu and Kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes
Belcheva MM, Clark AL, Haas PD, et al.: Mu and Kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem 2005;280:27662-27669.
Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: Implication for intracellular signalization cross-regulation
Bouaboula M, Desnoyer N, Carayon P, Combes T, Casellas P: Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: Implication for intracellular signalization cross-regulation. Mol Pharmacol 1999;55:473-480.
SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist
Portier M, Rinaldi-Carmona M, Pecceu F, et al.: SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist. J Pharmacol Exp Ther 1999;288:582-589.
Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242
Mancini I, Brusa R, Quadrato G, et al.: Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242. Br J Pharmacol 2009;158:382-391.
