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Volumn 19, Issue 17, 2011, Pages 5125-5136

Halogen-substituted (C-β-d-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase

(7) Alexacou, Kyra Melinda a,b Zhang, Yun Zhi c,d,e Praly, Jean Pierre c,d,e Zographos, Spyros E a Chrysina, Evangelia D a Oikonomakos, Nikos G a Leonidas, Demetres D f

a INSTITUTE OF BIOLOGY (Greece)

b FREIE UNIVERSITÄT BERLIN (Germany)

c UNIVERSITÉ LYON 1 (France)

d UNIVERSITÉ LYON 1 (France)

e CPE LYON (France)

f UNIVERSITY OF THESSALY (Greece)

Author keywords

C glucopyranosyl hydroquinone; C glucosyl aryl; Glycogen phosphorylase; Inhibition; Type 2 diabetes; X ray crystallography

Indexed keywords

2,5 DIHYDROXY 3 (BETA DEXTRO GLUCOPYRANOSYL)CHLOROBENZENE; 2,5 DIHYDROXY 4 (BETA DEXTRO GLUCOPYRANOSYL)BROMOBENZENE; 2,5 DIHYDROXY 4 (BETA DEXTRO GLUCOPYRANOSYL)CHLOROBENZENE; 3 (BETA DEXTRO GLUCOPYRANOSYL) 2 HYDROXY 5 METHOXYCHLOROBENZENE; 5 BROMO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 BENZOQUINONE; 5 BROMO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIMETHOXY BENZENE; 5 BROMO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) HYDROQUINONE; 5 CHLORO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 BENZOQUINONE; 5 CHLORO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIMETHOXY BENZENE; 5 CHLORO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) HYDROQUINONE; 6 BROMO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIMETHOXY BENZENE; 6 CHLORO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIMETHOXY BENZENE; 6 CHLORO 2 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) HYDROQUINONE; GLYCOGEN PHOSPHORYLASE; HYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DEACETYLATION; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HALOGENATION; IC 50; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCOGEN PHOSPHORYLASE; HALOGENS; HYDROQUINONES; KINETICS; MOLECULAR CONFORMATION; PROTEIN BINDING; STEREOISOMERISM;

TETRA;

EID: 84860389101 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.07.024 Document Type: Article

Times cited : (6)

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