Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage

Microbiology and Immunology

Volumn 56, Issue 5, 2012, Pages 338-341

  Umeda, Kaoru ^a   Seto, Yoshiyuki ^b   Kohda, Tomoko ^b   Mukamoto, Masafumi ^b   Kozaki, Shunji ^b  

^a OSAKA CITY INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Bont b gene encoding plasmid; Infant botulism; Serial passage; Toxigenicity

Indexed keywords

BONT B GENE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC STABILITY; GENETIC VARIABILITY; GENOTOXICITY; HUMAN; MICROBIAL COLONIZATION; NONHUMAN; NOTE; PLASMID; POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; VIRUS CULTURE; VIRUS GENE; VIRUS ISOLATION; VIRUS STRAIN;

BOTULINUM TOXINS; BOTULISM; CLOSTRIDIUM BOTULINUM TYPE B; HUMANS; PLASMIDS; SERIAL PASSAGE; VIRULENCE;

CLOSTRIDIUM BOTULINUM;

EID: 84860383070     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2012.00441.x     Document Type: Note

References (17)

1. Cai S., Singh B.R., Sharma S. (2007) Botulism diagnostics: from clinical symptoms to in vitro assays. Crit Rev Microbiol 33: 109-25.
2. Lindstrom M., Korkeala H. (2006) Laboratory diagnostics of botulism. Clin Microbiol Rev 19: 298-314.
3. Hill K.K., Smith T.J., Helma C.H., Ticknor L.O., Foley B.T., Svensson R.T., Brown J.L., Johnson E.A., Smith L.A., Okinaka R.T., Jackson P.J., Marks J. D. (2007) Genetic diversity among botulinum neurotoxin producing Clostridial strains. J Bacteriol 189: 818-32.
4. Smith T.J., Lou J., Geren I.N., Forsyth C.M., Tsai R., Laporte S.L., Tepp W.H., Bradshaw M., Johnson E.A., Smith L.A., Marks J.D. (2005) Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect Immun 73: 5450-7.
5. Umeda K., Seto Y., Kohda T., Mukamoto M., Kozaki S. (2009) Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. J Clin Microbiol 47: 2720-8.
6. Oguma K., Fujinaga Y., Inoue K. (1995) Structure and function of Clostridium botulinum toxins. Microbiol Immunol 39: 161-8.
7. Whelan S.M., Elmore M.J., Bodsworth N.J., Brehm J.K., Atkinson T., Minton N.P. (1992) Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence. Appl Environ Microbiol 58: 2345-54.
8. Zhou Y., Sugiyama H., Nakano H., Johnson E.A. (1995) The genes for the Clostridium botulinum type G toxin complex are on a plasmid. Infect Immun 63: 2087-91.
9. Franciosa G., Maugliani A., Scalfaro C., Aureli P. (2009) Evidence that plasmid-borne botulinum neurotoxin type B genes are widespread among Clostridium botulinum serotype B strains. PLoS ONE 4: e4829.
10. Takeshi K., Fujinaga Y., Inoue K., Nakajima H., Oguma K., Ueno T., Sunagawa H., Ohyama T. (1996) Simple method for detection of Clostridium botulinum type A to F neurotoxin genes by polymerase chain reaction. Microbiol Immunol 40: 5-11.
11. Eklund M.W., Poysky F.T., Mseitif L.M., Strom M.S. (1988) Evidence for plasmid-mediated toxin and bacteriocin production in Clostridium botulinum type G. Appl Environ Microbiol 54: 1405-8.
12. Yamakawa K., Karasawa T., Kakinuma H., Maruyama H., Takahashi H., Nakamura S. (1997) Emergence of Clostridium botulinum type B-like nontoxigenic organisms in a patient with type B infant botulism. J Clin Microbiol 35: 2163-4.
13. Bielaszewska M., Prager R., Kock R., Mellmann A., Zhang W., Tschape H., Tarr P.I., Karch H. (2007) Shiga toxin gene loss and transfer in vitro and in vivo during enterohemorrhagic Escherichia coli O26 infection in humans. Appl Environ Microbiol 73: 3144-50.
14. Raffestin S., Marvaud J.C., Cerrato R., Dupuy B., Popoff M. R. (2004) Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe 10: 93-100.
15. Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. (2007) Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. PLoS ONE 2 : e1271.
16. Kozaki S., Dufrenne J., Hagenaars A.M., Notermans S. (1979) Enzyme linked immunosorbent assay (ELISA) for detection of Clostridium botulinum type B toxin. Jpn J Med Sci Biol 32: 199-205.
17. Solomon H.M., Timothy L. Jr. (2001) Bacteriological analytical Manual chapter 17 Clostridium botulinum. USA Food and Drug Administration, Center for Food Safety and Applied Nutrition.