Nutrition and Wound Healing

Critical Care Nursing Clinics of North America

Volumn 24, Issue 2, 2012, Pages 179-200

  Williams, Jeremy Z ^a   Barbul, Adrian ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Immune related compromise; Nutritional depletion; Wound healing

Indexed keywords

EID: 84860354908     PISSN: 08995885     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccell.2012.03.001     Document Type: Review

References (156)

1. Hippocrates The genuine works of Hipocrates (translated from the Greek by Francis Adams) 1939, Williams & Wilkins, Baltimore.
2. DuBois E.F. Metabolism in fever and in certain infections. Endocrinology and metabolism 1922, vol IV, D:95-151. Appleton, New York. L.F. Barker (Ed.).
3. Cuthbertson D.P. The biochemical response to injury 1960, Charles C Thomas, Springfield (IL).
4. Thompson W.D., Ravdin I.S., Frank I.L. The effect of hypoproteinemia on wound disruption. Arch Surg 1938, 36:500.
5. Thompson W.D., Ravdin I.S., Rhoads J.E., et al. The use of lyophile plasma incorrection of hypoproteinemia and prevention of wound disruption. Arch Surg 1938, 36:509.
6. Rhoads J.E., Fliegelman M.T., Panzer L.M. The mechanism of delayed wound healing in the presence of hypoproteinemia. JAMA 1942, 118:21.
7. Levenson S.M., Demetriou A.A. Metabolic factors. Wound healing biochemical and clinical aspects 1992, 248-273. WB Saunders, Philadelphia.
8. Kay S.P., Moreland J.R., Schmitler E. Nutritional status and wound healing in lower extremity amputations. Clin Orthop 1987, 217:253.
9. Dickhaut S.C., DeLee J.C., Page C.P. Nutritional status: importance in predicting wound healing after amputation. J Bone Joint Surg Am 1984, 66:71.
10. Casey J., Flinn W.R., Yao J.S., et al. Correlation of immune and nutritional status with wound complications in patients undergoing vascular operations. Surgery 1983, 93:822.
11. Fischer J.E. Nutrition and metabolism in the surgical patient 1996, Little, Brown, Boston.
12. Cuthbertson D.P. Nutrition in relation to trauma and surgery. Prog Nutr Sci 1975, 1:263.
13. Bessey P.Q. Metabolic response to critical illness. Scientific American Surgery: Care of the surgical patient 1999, 1-26. WebMD Corporation, New York. D.W. Wilmore, L.Y. Cheung, A.H. Harken (Eds.).
14. Levenson S.M., Pirani C.L., Braasch J.W., et al. The effect of thermal burns on wound healing. Surg Gynecol Obstet 1954, 99:74.
15. Levenson S.M., Upjohn H.L., Preston J.A. Effect of thermal burns on wound healing. Ann Surg 1957, 146:357.
16. Crowley L.V., Seifter E., Kriss P., et al. Effects of environmental temperature and femoral fracture on wound healing in rats. J Trauma 1977, 17:436.
17. Levenson S.M., Crowley L.V., Oates J.F., et al. Effect of severe burn on liver regeneration. Surg Forum 1958, 9:493.
18. Jensen J.E., Jensen T.G., Smith T.K., et al. Nutrition in orthopaedic surgery. J Bone Joint Surg AM 1982, 64:1263.
19. Warnold I., Lundholm K. Clinical significance of preoperative nutritional status in 215 noncancer patients. Ann Surg 1984, 199:299.
20. Daley B.J., Bistrian B.R. Nutritional assessment. Nutrition in critical care 1994, 9-33. Mosby, St. Louis. G.P. Zaloga (Ed.).
21. Schwartz S.I. Principles of surgery 1994, McGraw-Hill, New York.
22. Yue D.K., McLennan S., Marsh M., et al. Abnormalities of granulation tissue and collagen formation in experimental diabetes, uremia and malnutrition. Diabet Med 1986, 3:221.
23. Spanheimer R.G., Peterkovsky B. A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented, guinea pigs. J Parenter Enteral Nutr 1986, 10:550.
24. Goodson W.H., Lopez-Sarmiento A., Jensen J.A., et al. The influences of a brief preoperative illness on postoperative healing. Ann Surg 1987, 205:250.
25. Windsor J.A., Knoght G.S., Hill G.L. Wound healing response in surgical patients: recent food intake is more important than nutritional status. Br J Surg 1988, 75:135.
26. Haydock D.A., Hill G.L. Improved wound healing response in surgical patients receiving intravenous nutrition. Br J Surg 1987, 74:320.
27. Schroeder D., Gillanders L., Mahr R., et al. Effects of immediate postoperative nutrition in body composition, muscle function and wound healing. J Parenter Enteral Nutr 1991, 15:376.
28. Albina J.E. Nutrition and wound healing. J Parenter Enteral Nutr 1994, 18:367.
29. Barbul A., Purtill W.A. Nutrition in wound healing. Clin Dermatol 1994, 12:133.
30. Goodson W.H., Hunt T.K. Wound collagen accumulation in obese hyperglycemic mice. Diabetes 1986, 35:491.
31. Barr L.C., Joyce A.D. Microvascular anastamoses in diabetes: an experimental study. Br J Plast Surg 1989, 42:50.
32. Weringer E.J., Kelso J.M., Tamai I.Y., et al. Effects of insulin in wound healing in diabetic mice. Acta Endocrinol 1982, 99:101.
33. Weringer E.J., Arquilla E.R. Wound healing in normal and diabetic Chinese hamsters. Diabetologia 1981, 4:394.
34. Weringer E.J., Kelso J.M., Tamai I.Y., et al. The effect of antisera to insulin, 2-deoxyglucose-induced hyperglycemia and starvation on wound healing in normal mice. Diabetes 1981, 30:407.
35. Hanam S.R., Singleton C.E., Rudek W. The effect of topical insulin on infected cutaneous ulcerations in diabetic and nondiabetic mice. J Foot Surg 1983, 22:298.
36. Goodson W.H., Hunt T.K. Studies of wound healing in experimental diabetes mellitus. J Surg Res 1977, 22:221.
37. Mann G.V. The impairment of transport of amino acid by monosaccharides [abstract. Fed Proc 1974, 33:251.
38. Mann G.V. The membrane transport of ascorbic acid. Ann N Y Acad Sci 1974, 258:243.
39. Schneir M., Rettura G., et al. Dietary ascorbic acid increases collagen production in skin of stretozotocin induced diabetic rats by normalizing ribosomal efficiency. Ann N Y Acad Sci 1987, 194:42.
40. Burr G.O., Burr M.M. A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 1929, 82:345.
41. Burr G.O., Burr M.M. On the nature and role of the fatty acids essential in nutrition. J Biol Chem 1930, 86:587.
42. Hulsey T.K., O'Neill J.A., Neblett W.R., et al. Experimental wound healing in essential fatty acid deficiency. J Pediatr Surg 1980, 15:505.
43. Caffrey B.B., Jonnson J.T. Role of essential fatty acids in wound healing in rats. Prog Lipid Res 1981, 20:641.
44. Caldwell M.D., Jonsson H.T., Othersen H.B. Essential fatty acid deficiency in an infant receiving prolonged parenteral alimentation. J Pediatr 1972, 81:894.
45. Nordenstrom J., Carpentier Y.A., Askanazi J., et al. Essential fatty acid deficiency and apparent wound healing in an infant with gastroschisis. Am Surg 1983, 197:725.
46. Wolfram G., Eckart J., Walther B., et al. Free fatty acid mobilization and oxidation during total parenteral nutrition in trauma and infection. Ann Surg 1983, 198:275.
47. Wolfram G., Eckart J., Walther B., et al. Factors influencing essential fatty acid requirements in total parenteral nutrition. J Parenter Enteral Nutr 1978, 2:634.
48. Wene J.D., Connor W.E., DenBesten L. The development of essential fatty acid deficiency in men fed fat free diets intravenously and orally. J Clin Invest 1975, 56:127.
49. Greig P.D., Baker J.P., Jeejeebhoy K.N. Metabolic effects of total parenteral nutrition. Annu Rev Nutr 1982, 2:179.
50. Albina J.E., Gladden P., Walsh W.R. Detrimental effects of omega-3 fatty acid-enriched diet on wound healing. J Parenter Enteral Nutr 1993, 17:519.
51. Simopoulos A.L. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1993, 54:438.
52. Prickett J.D., Robinson D.R., Steinberg A.D. Effects of dietary enrichment with eicosapentanoic acid upon autoimmune nephritis in female NZBxNZW/F1 mice. Arthritis Rheum 1983, 26:133.
53. Kremer J.M., Jubiz W., Michalek A., et al. Fish oil fatty acid supplementation in active rheumatoid arthritis: a double-blind, controlled, crossover study. Ann Intern Med 1987, 106:497.
54. Sperling R.I., Robin J.L., Kylander K.A., et al. The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor by human monocytes. J Immunol 1987, 139:4186.
55. Endres S., Ghorbani R., Kelly V.E., et al. The effect of dietary supplementation with N-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989, 320:265.
56. Irvin T.T. Effects of malnutrition and hyperalimentation on wound healing. Surg Gynecol Obstet 1978, 146:33.
57. Spanheimer R.G., Peterkovsky B. A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented, guinea pigs. J Biol Chem 1985, 260:3955.
58. Haydock G.A., Hill G.L. Impaired wound healing in surgical patients with varying degrees of malnutrition. J Parenter Enteral Nutr 1986, 10:550.
59. Williamson M.B., Fromm H.J. The incorporation of sulfur amino acids into protein of regenerating wound tissue. J Biol Chem 1955, 212:705.
60. Localio S.A., Morgan M.E., Hintown R. The biological chemistry of wound healing: the effect of di-methionine on healing of wounds in protein depleted animals. Surg Gynecol Obstet 1948, 86:582.
61. Cerra F.B., Upson D., Angelico R., et al. Branched chains support postoperative protein synthesis. Surgery 1982, 92:192.
62. Cerra F.B., Shronts E.P., Konstantinides N.N., et al. Enteral feeding in sepsis: a prospective, randomized double blind trial. Surgery 1985, 98:632.
63. Sax H.C., Talamini M.A., Fischer J.E. Clinical use of branched chain amino acids in liver disease, trauma, sepsis and burns. Arch Surg 1986, 121:358.
64. Cerra F.B., Siegel J.H., Coleman B., et al. Septic autocannibalism: a failure of exogenous nutritional support. Ann Surg 1980, 192:570.
65. Hedden M.P., Buse M.G. General stimulation of muscle protein synthesis by branched chain amino acids in vitro. Proc Soc Exp Biol Med 1979, 160:410.
66. Buse M.G., Reid S.S. Leucine, a possible regulator of protein turnover in muscles. J Clin Invest 1975, 56:1250.
67. Freund H.R., Lapidot A., Fischer J.E. The use of branched chain amino acids in the injured-septic patient. Metabolism and clinical implications of branch chain amino and ketoacids 1981, 527-532. Elsevier, New York. M. Walser, J.R. Williamson (Eds.).
68. McCauley R., Platell C., Hall J., et al. Influence of branched chain amino acid solutions on wound healing. Aust N Z J Surg 1990, 60:471.
69. Dudrick S.J., Matheny R.G., et al. Effect of enriched branched chain amino acid solutions in traumatized rats [abstract. J Parenter Enteral Nutr 1984, 8:86.
70. Demling R.H., Desanti L. Involuntary weight loss and the nonhealing wound: the role of anabolic agents. Adv Wound Care 1999, 12(Suppl):1.
71. Bergstrom J., Furst P., Noree L.O., et al. Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 1974, 36:693.
72. Zetterberg A., Engstrom W. Glutamine and the regulation of DNA replication and cell multiplication in fibroblasts. J Cell Physiol 1981, 108:365.
73. Zielke H.R., Ozand P.T., Tildon J.T., et al. Growth of human diploid fibroblasts in the absence of glucose utilization. Proc Natl Acad Sci U S A 1976, 73:4110.
74. Ardawi M.S.M., Newsholme P. Glutamine metabolism in lymphocytes of the rat. Biochem 1983, 212:835-842.
75. Newsholme E.A., Newsholme P. A role for muscle in the immune system and its importance in surgery, trauma, sepsis and burns. Nutrition 1988, 4:261.
76. Demling R.H., Desanti L. Involuntary weight loss and the nonhealing wound: the role of anabolic agents. Adv Wound Care 1999, 12(Suppl):1.
77. Askanazi J., Carpentier Y.A., Michelsen C.B., et al. Muscle and plasma amino acids following injury: influence of intercurrent infection. Ann Surg 1980, 192:78.
78. Roth E., Funovics J. Metabolic disorders in sever abdominal sepsis: glutamine deficiency in skeletal muscle. Clin Nutr 1982, 1:25.
79. Ziegler T.R., Young L.S., Benfell K., et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplant. A randomized, double-blind, controlled study. Ann Intern Med 1992, 116:821.
80. McCauly R., Platell C., Hall J., et al. Effects of glutamine on colonic strength anastamosis in the rat. J Parenter Enteral Nutr 1991, 15:437.
81. Rose W.C. The nutritive significance of the amino acids and certain related compounds. Science 1937, 86:298.
82. Barbul A. Biochemistry, physiology and therapeutic implications. J Parenter Enteral Nutr 1986, 10:227.
83. Rose W.C. Amino acid requirements of man. Fed Proc 1949, 8:546.
84. Seifter E., Rettura G., Barbul A., et al. Arginine: an essential amino acid for injured rats. Surgery 1978, 84:224.
85. Barbul A., Fishel R.S., Shimazu S., et al. Intravenous hyperalimentation with high arginine levels improves wound healing and immune function. J Surg Res 1985, 38:328.
86. Chyun J., Griminger P. Improvement of nitrogen retention by arginine and glycine supplementation and its relation to collagen synthesis. J Nutr 1984, 114:1697.
87. Goodson W.H., Hunt T.K. Development of a new miniature method for the study of wound healing in human subjects. J Surg Res 1982, 33:394.
88. Barbul A., Lazarou S.A., Efron D.T., et al. Arginine enhances wound healing and lymphocyte immune response in humans. Surgery 1991, 108:331.
89. Kirk S.J., Hurston M., Regan M.C., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993, 114:155.
90. Albina J.E., Mills C.D., Barbul A., et al. Arginine metabolism in wounds. Am J Phys 1988, 254:E459.
91. Albina J.E., Mastrofrancesco B. Role of ornithine as proline precursor in healing wounds. J Surg Res 1993, 55:97.
92. Kowalewski K., Young S. Effect of growth hormone and an anabolic steroid on hydroxyproline in healing dermal wounds in rats. Acta Endocrinol 1968, 59:53.
93. Jorgensen P.H., Andreassen T.T. Influence of biosynthetic human growth hormone on biochemical properties of rat skin incisional wounds. Acta Chir Scand 1988, 154:623.
94. Herndon D.N., Barrow R.E., Kunkel K.R., et al. Effects of recombinant human growth hormone on donor site-healing in severely burned children. Ann Surg 1990, 212:424.
95. Barbul A., Rettura G., Levenson S.M., et al. Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Am J Clin Nutr 1983, 37:786.
96. Barbul A., Wasserkrug H.L., Seifter E., et al. Immunostimulatory effects of arginine in normal and injured rats. J Surg Res 1980, 29:228.
97. Barbul A., Wassekrug H.L., Sisto D.A., et al. Thymic stimulatory actions of arginine. J Parenter Enteral Nutr 1980, 4:446.
98. Barbul A., Wasserkrug H.L., Yoshimura N., et al. High arginine levels in intravenous hyperalimentation abrogate post-traumatic immune suppression. J Surg Res 1984, 36:620.
99. Agaiby A.D., Dyson M. Immuno-inflammatory cell dynamics during cutaneous wound healing. J Anat 1999, 195:531.
100. Fishel R.S., Barbul A., Beschorner W.E., et al. Lymphocyte participation in wound healing: morphologic assessment using monoclonal antibodies. Ann Surg 1987, 206:25.
101. Peterson J.M., Barbul A., Breslin R.J., et al. Significance of T lymphocytes in wound healing. Surgery 1987, 102:300.
102. Barbul A. Role of T cell-dependent immune system in wound healing. Growth factors and other aspects of wound healing: biologic and clinical implications 1988, 161-175. Alan R. Liss, New York.
103. Schaffer M.R., Tantry U., Thornton F.J., et al. Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice. Eur J Surg 1999, 165:262.
104. Efron D.T., Thornton F.J., Steulten C., et al. Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing. J Gastrointest Surg 1999, 3:592.
105. Schaffer M.R., Efron P.A., Thornton F.J., et al. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. J Immunol 1997, 158:2375.
106. Thornton F.J., Schaffer M.R., Witte M.B., et al. Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds. Biochem Biophys Res Commun 1998, 246:654.
107. Yamasaki K., Edington H.D., McClosky C., et al. Reversal of impaired wounds repair in iNOS deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998, 101:967.
108. Shi H.P., Efron D.T., Most D., et al. Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice. Surgery 2000, 128:374.
109. Osler W. The principles and practice of medicine 1892, New York, D. Appleton & Company.
110. Englard S., Seifter E. The biochemical functions of ascorbic acid. Annu Rev Nutr 1986, 6:365.
111. Crandon J.H., Lund C.C., Dill D.B., et al. Experimental human scurvy. N Engl J Med 1940, 223:353.
112. Lanman T.H., Ingalls T.H. Vitamin C deficiency and wound healing (experimental and clinical study). Ann Surg 1937, 105:516.
113. Bourne G.H. Effect of vitamin C deficiency on experimental wounds: tensile strength and histology. Lancet 1944, 1:688.
114. Kivirikko K.I., Helaakoski T., Tasanen K., et al. Molecular biology of prolyl 4-hydroxylase. Ann N Y Acad Sci 1990, 580:132.
115. Lund C.C., Levenson S.M., Green R.W., et al. Ascorbic acid, thiamine riboflavin and nicotinic acid in relation to acute burns in man. Arch Surg 1947, 55:557.
116. Rivers J.M. Safety of high level vitamin C injection. Ann N Y Acad Sci 1987, 498:445.
117. Brandaleone H., Papper E. The effect of the local and oral administration of cod liver oil on the rate of wound healing in vitamin A deficient and normal animals. Ann Surg 1941, 114:791.
118. Ehrlich H.P., Hunt T.K. Effects of cortisone and vitamin A on wound healing. Ann Surg 1968, 167:324.
119. Levenson S.M., Seifter E., VanWinkle W. Nutrition. Fundamentals of wound management in surgery 1979, 286-363. Appleton-Century-Crofts, New York. T.K. Hunt, J.E. Dunphy (Eds.).
120. Goodson W.H., Hunt T.K. Wound healing and nutrition. Nutrition and metabolism in patient care 1988, 635-642. WB Saunders, Philadelphia. J.M. Kinney, K.N. Jeejeebhoy, G.L. Hill (Eds.).
121. Seifter E., Rettura G., Padawer J., et al. Impaired wound healing in streptozotocin diabetes: prevention by supplemental vitamin A. Ann Surg 1981, 194:42.
122. Weinzweig J., Levenson S.M., Rettura G., et al. Supplemental vitamin A prevents the tumor induced defect in wound healing. Ann Surg 1990, 211:269.
123. Stratford F., Seifter E. Impaired wound healing by cyclophosphamide: alleviation by supplemental vitamin A. Surg Forum 1980, 31:224.
124. Levenson S.M., Gruber C.A., Rettura G., et al. Supplemental vitamin A prevents the acute radiation-induced defect in wound healing. Ann Surg 1984, 200:494.
125. Demetriou A.A., Levenson S.M., Rettura G., et al. Vitamin A and retinoic acid: induced fibroblast differentiation in vitro. Surgery 1985, 98:931.
126. Jetten A.M. Modulation of cell growth by retinoids and their possible mechanisms of action. Fed Proc 1984, 43:134.
127. Moody B.J. Changes in the serum concentrations of thyroxine-binding prealbumin and retinol binding protein following burn injury. Clin Chim Act 1982, 118:87.
128. Rai K., Coutemanche A.J. Vitamin A assay in burned patients. J Trauma 1975, 15:419.
129. Ramsden D.B., Prince H.P., Burr W.A., et al. The interrelationship of thyroid hormones, vitamin A and the binding proteins following stress. Clin Endocrinol 1978, 8:109.
130. Demling R.H., DeBiasse M. Micronutrients in critical illness. Crit Care Clin 1995, 11:651.
131. Hunt T.K. Vitamin A and wound healing. J Am Acad Dermatol 1986, 15:817.
132. Baxter C.R. Immunologic reactions in chronic wounds. Am J Surg 1994, 167:12.
133. Shukla A., Rasik A.M., Patnaik G.K. Depletion of reduced glutathione, ascorbic acid, and vitamin E and antioxidant defense enzymes in a healing cutaneous wound. Free Radic Res 1997, 26:93.
134. Nimni M.E. Mechanism of collagen crosslinking by penicillamine. Proc R Soc Med 1977, 70:65.
135. Geever E.F., Youssef S.A., Seifter E., et al. Penicillamine and wound healing in young guinea pigs. J Surg Res 1967, 6:160.
136. Todd W.R., Elvehjem C.A., Hart E.B. Zinc in nutrition of the rat. Am J Physiol 1934, 107:146.
137. Vallee B.L. Metabolic role of zinc: report of Council of Foods and Nutrition. JAMA 1956, 162:1053.
138. Ramsden D.B., Prince H.P., Burr W.A., et al. The interrelationship of thyroid hormones, vitamin A and their binding proteins following stress. Clin Endocrinol 1978, 8:109.
139. Prasad A.S., Miale A. Biochemical studies on dwarfism, hypogonadism and anemia. Arch Intern Med 1963, 111:407.
140. Prasad A.S. Acquired zinc deficiency and immune dysfunction in sickle cell anemia. Nutrient modulation of the immune response 1993, 393-410. Marcel Dekker, New York. S. Cunningham-Rundles (Ed.).
141. Hallbrook T., Lanner E. Serum zinc and healing of leg ulcers. Lancet 1972, 2:780.
142. Raahave D., Friis-Moller A., Bjerre-Jepsen K., et al. The infective dose of aerobic and anaerobic bacteria in postoperative wound sepsis. Arch Surg 1986, 121:924.
143. Robson M.C., Shaw R.C., Heggers J.P. The reclosure of postoperative incisional abcesses based on bacterial quantification of the wound. Ann Surg 1970, 171:279.
144. Thornton F.J., Schaffer M.R., Barbul A. Wound healing in sepsis and trauma. Shock 1997, 8:391.
145. Kinney J.M. Energy requirements of the surgical patient. Manual of surgical nutrition 1975, 223-235. WB Saunders, Philadelphia. W.F. Ballinger, J.A. Collins, W.R. Druker (Eds.).
146. Streats S.J., Hill G.L. Nutritional support in the management of critically ill patients in surgical intensive care. World J Surg 1987, 11:194.
147. Dickhaut S.C., DeLee J.C., Page C.P. Nutritional status: importance in predicting wound healing after amputation. J Bone Joint Surg Am 1984, 66:71.
148. Christou N. Perioperative nutritional support: immunologic defects. J Parenter Enteral Nutr 1990, 14:186S.
149. Levenson S.M., Seifter E., Walton V.W. Fundamentals of wound management in surgery 1977, Chirurgecom, South Plainfield (NJ).
150. Mullen J.L., Buzby G.P., Matthews D.C., et al. Reduction of operative morbidity and mortality by combined preoperative and postoperative nutritional support. Ann Surg 1980, 192:604.
151. Williams R.H., Heatley R.V., Lewis M.H. Proceedings: a randomized control trial of preoperative intravenous nutrition in patients with stomach cancer. Br J Surg 1976, 6:667.
152. Zaloga G.P., Knowles R., Black K.W., et al. TPN increases mortality after hemorrhage. Crit Care Med 1991, 19:54.
153. Kudsk K.A., Stone J.M., Carpenter G., et al. Enteral and parenteral nutrition influences mortality after hemoglobin-E. coli peritonitis in normal rats. J Trauma 1983, 23:605.
154. Delany H.M., John J., Teh E.L., et al. Contrasting effects of identical nutrients given parenterally or enterally after 70% hepatectomy. Am J Surg 1994, 167:135.
155. Lin M.T., Saito H., Fukushima R., et al. Route of nutritional supple influences local, systemic and remote organ responses to intraperitoneal bacterial challenge. Ann Surg 1996, 223:84.
156. Kiyama T., Witte M.B., Thornton F.J., et al. The route of nutrition support affects the early phase of wound healing. J Parenter Enteral Nutr 1998, 22:276.