Acute ST-segment elevation myocardial infarction is associated with decreased human antimicrobial peptide LL-37 and increased human neutrophil peptide-1 to 3 in plasma

Journal of Atherosclerosis and Thrombosis

Volumn 19, Issue 4, 2012, Pages 357-368

  Zhao, Hanjun ^a,b   Yan, Hongbing ^a,b   Yamashita, Shizuya ^c   Li, Wenzheng ^b   Liu, Chen ^a   Chen, Yi ^b   Zhou, Peng ^b   Chi, Yunpeng ^b   Wang, Shaoping ^b   Zhao, Bo ^b   Song, Li ^a  

^a FUWAI HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute myocardial infarction; Alpha defensin; HNP1 3; Inflammation; LL 37

Indexed keywords

C REACTIVE PROTEIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CELL PROTEIN; HUMAN NEUTROPHIL PEPTIDE 1 3; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ALPHA-DEFENSINS; CATHELICIDINS; ELECTROCARDIOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MYOCARDIAL INFARCTION; ROC CURVE;

EID: 84860346285     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.10108     Document Type: Article

References (27)

1. Libby P, Okamoto Y, Rocha VZ, Folco E: Inflammation in atherosclerosis: transition from theory to practice. Circ J, 2010; 74: 213-220
2. De Servi S, Mariani M, Mariani G, Mazzone A: C-reactive protein increase in unstable coronary disease cause or effect? J Am Coll Cardiol, 2005; 46: 1496-1502
3. Maier W, Altwegg LA, Corti R, Gay S, Hersberger M, Maly FE, Sutsch G, Roffi M, Neidhart M, Eberli FR, Tanner FC, Gobbi S, von Eckardstein A, Luscher TF: Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation, 2005; 111: 1355-1361
4. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C: Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis. J Cell Mol Med, 2005; 9: 3-10
5. Li Y: The role of antimicrobial peptides in cardiovascular physiology and disease. Biochem Biophys Res Commun, 2009; 390: 363-367
6. Bdeir K, Cane W, Canziani G, Chaiken I, Weisel J, Koschinsky ML, Lawn RM, Bannerman PG, Sachais BS, Kuo A, Hancock MA, Tomaszewski J, Raghunath PN, Ganz T, Higazi AA, Cines DB: Defensin promotes the binding of lipoprotein(a) to vascular matrix. Blood, 1999; 94: 2007-2019
7. He C, Huang R, Du F, Zheng F, Wei L, Wu J: LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1. Clin Chim Acta, 2009; 402: 102-106
8. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C: Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg, 2006; 43: 357-363
9. Nassar T, Akkawi S, Bar-Shavit R, Haj-Yehia A, Bdeir K, Al-Mehdi AB, Tarshis M, Higazi AA: Human alphadefensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Blood, 2002; 100: 4026-4032
10. Higazi AA, Barghouti II, Abu-Much R: Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. A role for defensin. J Biol Chem, 1995; 270: 9472-9477
11. Higazi AA, Ganz T, Kariko K, Cines DB: Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells. J Biol Chem, 1996; 271: 17650-17655
12. Bokarewa M, Tarkowski A: Human alpha -defensins neutralize fibrinolytic activity exerted by staphylokinase. Thromb Haemost, 2004; 91: 991-999
13. Chavakis T, Cines DB, Rhee JS, Liang OD, Schubert U, Hammes HP, Higazi AA, Nawroth PP, Preissner KT, Bdeir K: Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. FASEB J, 2004; 18: 1306-1308
14. Edfeldt K, Agerberth B, Rottenberg ME, Gudmundsson GH, Wang XB, Mandal K, Xu Q, Yan ZQ: Involvement of the antimicrobial peptide LL-37 in human atherosclerosis. Arterioscler Thromb Vasc Biol, 2006; 26: 1551-1557
15. Ciornei CD, Tapper H, Bjartell A, Sternby NH, Bodelsson M: Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study. BMC Cardiovasc Disord, 2006; 6: 49
16. Zanetti M: The role of cathelicidins in the innate host defenses of mammals. Curr Issues Mol Biol, 2005; 7: 179-196
17. Haider H, Akbar SA, Ashraf M: Angiomyogenesis for myocardial repair. Antioxid Redox Signal, 2009; 11: 1929-1944
18. Park HJ, Cho DH, Kim HJ, Lee JY, Cho BK, Bang SI, Song SY, Yamasaki K, Di Nardo A, Gallo RL: Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37. J Invest Dermatol, 2009; 129: 843-850
19. Tomasinsig L, Pizzirani C, Skerlavaj B, Pellegatti P, Gulinelli S, Tossi A, Di Virgilio F, Zanetti M: The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner. J Biol Chem, 2008; 283: 30471-30481
20. Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T, Issbrucker K, Unterberger P, Zaiou M, Lebherz C, Karl A, Raake P, Pfosser A, Boekstegers P, Welsch U, Hiemstra PS, Vogelmeier C, Gallo RL, Clauss M, Bals R: An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest, 2003; 111: 1665-1672
21. Quinn K, Henriques M, Parker T, Slutsky AS, Zhang H: Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. Am J Physiol Heart Circ Physiol, 2008; 295: H1817-H1824
22. Nassar H, Lavi E, Akkawi S, Bdeir K, Heyman SN, Raghunath PN, Tomaszewski J, Higazi AA: alpha-Defensin: link between inflammation and atherosclerosis. Atherosclerosis, 2007; 194: 452-457
23. Barnathan ES, Raghunath PN, Tomaszewski JE, Ganz T, Cines DB, Higazi AA: Immunohistochemical localization of defensin in human coronary vessels. Am J Pathol, 1997; 150: 1009-1020
24. Higazi AA, Lavi E, Bdeir K, Ulrich AM, Jamieson DG, Rader DJ, Usher DC, Kane W, Ganz T, Cines DB: Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. Blood, 1997; 89: 4290-4298
25. Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB: The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. Blood, 2000; 96: 1393-1398
26. Joseph G, Tarnow L, Astrup AS, Hansen TK, Parving HH, Flyvbjerg A, Frystyk J: Plasma alpha-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients. J Clin Endocrinol Metab, 2008; 93: 1470-1475
27. Frangogiannis NG, Smith CW, Entman ML: The inflammatory response in myocardial infarction. Cardiovasc Res, 2002; 53: 31-47