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Volumn 42, Issue 5, 2012, Pages 1129-1139

IL-15 inhibits IL-7Rα expression by memory-phenotype CD8 + T cells in the bone marrow

Author keywords

chain cytokines; T cell homeostasis; T cell memory; T cell recirculation

Indexed keywords

HERMES ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; MESSENGER RNA; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FKHR;

EID: 84860335345     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142019     Document Type: Article
Times cited : (21)

References (45)
  • 1
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman, Y., Spolski, R. and Leonard, W. J., New insights into the regulation of T cells by gamma(c) family cytokines. Nat. Rev. Immunol. 2009. 9: 480-490.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 2
    • 79955418828 scopus 로고    scopus 로고
    • Harnessing the biology of IL-7 for therapeutic application
    • Mackall, C. L., Fry, T. J. and Gress, R. E., Harnessing the biology of IL-7 for therapeutic application. Nat. Rev. Immunol. 2011. 11: 330-342.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 330-342
    • Mackall, C.L.1    Fry, T.J.2    Gress, R.E.3
  • 3
    • 71849101656 scopus 로고    scopus 로고
    • The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis
    • Rochman, Y. and Leonard, W. J., The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J. Immunol. 2008. 181: 7699-7705.
    • (2008) J. Immunol. , vol.181 , pp. 7699-7705
    • Rochman, Y.1    Leonard, W.J.2
  • 4
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naive and memory T cells
    • Boyman, O., Letourneau, S., Krieg, C. and Sprent, J., Homeostatic proliferation and survival of naive and memory T cells. Eur. J. Immunol. 2009. 39: 2088-2094.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2088-2094
    • Boyman, O.1    Letourneau, S.2    Krieg, C.3    Sprent, J.4
  • 5
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D. and Ahmed, R., Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 2003. 4: 1191-1198.
    • (2003) Nat. Immunol. , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 6
    • 4143085811 scopus 로고    scopus 로고
    • Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
    • Park, J. H., Yu, Q., Erman, B., Appelbaum, J. S., Montoya-Durango, D., Grimes, H. L. and Singer, A., Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004. 21: 289-302.
    • (2004) Immunity , vol.21 , pp. 289-302
    • Park, J.H.1    Yu, Q.2    Erman, B.3    Appelbaum, J.S.4    Montoya-Durango, D.5    Grimes, H.L.6    Singer, A.7
  • 7
    • 45449109453 scopus 로고    scopus 로고
    • Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling
    • Alves, N. L., van Leeuwen, E. M., Derks, I. A. and van Lier, R. A., Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J. Immunol. 2008. 180:5201-5210.
    • (2008) J. Immunol. , vol.180 , pp. 5201-5210
    • Alves, N.L.1    van Leeuwen, E.M.2    Derks, I.A.3    van Lier, R.A.4
  • 8
    • 1842681952 scopus 로고    scopus 로고
    • Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    • Huster, K. M., Busch, V., Schiemann, M., Linkemann, K., Kerksiek, K. M., Wagner, H. and Busch, D. H., Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. USA 2004. 101: 5610-5615.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5610-5615
    • Huster, K.M.1    Busch, V.2    Schiemann, M.3    Linkemann, K.4    Kerksiek, K.M.5    Wagner, H.6    Busch, D.H.7
  • 9
    • 25444446578 scopus 로고    scopus 로고
    • IL-7 receptor expression levels do not identify CD8 +memory T lymphocyte precursors following peptide immunization
    • Lacombe, M. H., Hardy, M. P., Rooney, J. and Labrecque, N., IL-7 receptor expression levels do not identify CD8 +memory T lymphocyte precursors following peptide immunization. J. Immunol. 2005. 175: 4400-4407.
    • (2005) J. Immunol. , vol.175 , pp. 4400-4407
    • Lacombe, M.H.1    Hardy, M.P.2    Rooney, J.3    Labrecque, N.4
  • 10
    • 20444408804 scopus 로고    scopus 로고
    • CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow
    • Parretta, E., Cassese, G., Barba, P., Santoni, A., Guardiola, J. and Di Rosa, F., CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow. J. Immunol. 2005. 174: 7654-7664.
    • (2005) J. Immunol. , vol.174 , pp. 7654-7664
    • Parretta, E.1    Cassese, G.2    Barba, P.3    Santoni, A.4    Guardiola, J.5    Di Rosa, F.6
  • 11
    • 34548856484 scopus 로고    scopus 로고
    • Bone marrow CD8 cells down-modulate membrane IL-7R{alpha} expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment
    • Cassese, G., Parretta, E., Pisapia, L., Santoni, A., Guardiola, J. and Di Rosa, F., Bone marrow CD8 cells down-modulate membrane IL-7R{alpha} expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. Blood 2007. 110: 1960-1969.
    • (2007) Blood , vol.110 , pp. 1960-1969
    • Cassese, G.1    Parretta, E.2    Pisapia, L.3    Santoni, A.4    Guardiola, J.5    Di Rosa, F.6
  • 12
    • 12444303174 scopus 로고    scopus 로고
    • Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells
    • Becker, T. C., Coley, S. M., Wherry, E. J. and Ahmed, R., Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J. Immunol. 2005. 174: 1269-1273.
    • (2005) J. Immunol. , vol.174 , pp. 1269-1273
    • Becker, T.C.1    Coley, S.M.2    Wherry, E.J.3    Ahmed, R.4
  • 13
    • 20644461911 scopus 로고    scopus 로고
    • The bone marrow: a nest for migratory memory T cells
    • Di Rosa, F. and Pabst, R., The bone marrow: a nest for migratory memory T cells. Trends Immunol. 2005. 26: 360-366.
    • (2005) Trends Immunol. , vol.26 , pp. 360-366
    • Di Rosa, F.1    Pabst, R.2
  • 14
    • 13844272211 scopus 로고    scopus 로고
    • Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells
    • Mazo, I. B., Honczarenko, M., Leung, H., Cavanagh, L. L., Bonasio, R., Weninger, W., Engelke, K. et al., Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 2005. 22: 259-270.
    • (2005) Immunity , vol.22 , pp. 259-270
    • Mazo, I.B.1    Honczarenko, M.2    Leung, H.3    Cavanagh, L.L.4    Bonasio, R.5    Weninger, W.6    Engelke, K.7
  • 15
    • 47249143671 scopus 로고    scopus 로고
    • Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow
    • Parretta, E., Cassese, G., Santoni, A., Guardiola, J., Vecchio, A. and Di Rosa, F., Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow. J. Immunol. 2008. 180: 7230-7239.
    • (2008) J. Immunol. , vol.180 , pp. 7230-7239
    • Parretta, E.1    Cassese, G.2    Santoni, A.3    Guardiola, J.4    Vecchio, A.5    Di Rosa, F.6
  • 16
    • 58149402216 scopus 로고    scopus 로고
    • T-lymphocyte interaction with stromal, bone and hematopoietic cells in the bone marrow
    • Di Rosa, F., T-lymphocyte interaction with stromal, bone and hematopoietic cells in the bone marrow. Immunol. Cell. Biol. 2009. 87: 20-29.
    • (2009) Immunol. Cell. Biol. , vol.87 , pp. 20-29
    • Di Rosa, F.1
  • 17
    • 0036316236 scopus 로고    scopus 로고
    • Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery
    • Di Rosa, F. and Santoni, A., Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery. Eur. J. Immunol. 2002. 32: 1873-1880.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1873-1880
    • Di Rosa, F.1    Santoni, A.2
  • 18
    • 0035048973 scopus 로고    scopus 로고
    • Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    • Feuerer, M., Beckhove, P., Bai, L., Solomayer, E. F., Bastert, G., Diel, I. J., Pedain, C. et al., Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Nat. Med. 2001. 7: 452-458.
    • (2001) Nat. Med. , vol.7 , pp. 452-458
    • Feuerer, M.1    Beckhove, P.2    Bai, L.3    Solomayer, E.F.4    Bastert, G.5    Diel, I.J.6    Pedain, C.7
  • 19
    • 0025169081 scopus 로고
    • Phenotype analysis of lymphocyte subsets in normal human bone marrow
    • Clark, P. and Normansell, D. E., Phenotype analysis of lymphocyte subsets in normal human bone marrow. Am. J. Clin. Pathol. 1990. 94: 632-636.
    • (1990) Am. J. Clin. Pathol. , vol.94 , pp. 632-636
    • Clark, P.1    Normansell, D.E.2
  • 20
    • 33751207432 scopus 로고    scopus 로고
    • Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells
    • Banham, A. H., Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. Trends Immunol. 2006. 27: 541-544.
    • (2006) Trends Immunol. , vol.27 , pp. 541-544
    • Banham, A.H.1
  • 21
    • 77957374578 scopus 로고    scopus 로고
    • Interleukin-7 in HIV pathogenesis and therapy
    • Chahroudi, A. and Silvestri, G., Interleukin-7 in HIV pathogenesis and therapy. Eur. Cytokine Netw. 2010. 21: 202-207.
    • (2010) Eur. Cytokine Netw. , vol.21 , pp. 202-207
    • Chahroudi, A.1    Silvestri, G.2
  • 22
    • 78549287788 scopus 로고    scopus 로고
    • Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy
    • Bai, F., Bellistri, G. M., Tincati, C., Savoldi, A., Pandolfo, A., Bini, T., Carpani, G. et al., Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy. AIDS 2010. 24: 2590-2593.
    • (2010) AIDS , vol.24 , pp. 2590-2593
    • Bai, F.1    Bellistri, G.M.2    Tincati, C.3    Savoldi, A.4    Pandolfo, A.5    Bini, T.6    Carpani, G.7
  • 23
    • 34548368541 scopus 로고    scopus 로고
    • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    • Lundmark, F., Duvefelt, K., Iacobaeus, E., Kockum, I., Wallstrom, E., Khademi, M., Oturai, A. et al., Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat. Genet. 2007. 39: 1108-1113.
    • (2007) Nat. Genet. , vol.39 , pp. 1108-1113
    • Lundmark, F.1    Duvefelt, K.2    Iacobaeus, E.3    Kockum, I.4    Wallstrom, E.5    Khademi, M.6    Oturai, A.7
  • 24
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd, J. A., Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R. et al., Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 2007. 39: 857-864.
    • (2007) Nat. Genet. , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5    Plagnol, V.6    Bailey, R.7
  • 25
    • 3342934648 scopus 로고    scopus 로고
    • Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment
    • Vosshenrich, C. A., Cumano, A., Muller, W., Di Santo, J. P. and Vieira, P., Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. Proc. Natl. Acad. Sci. USA 2004. 101: 11070-11075.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11070-11075
    • Vosshenrich, C.A.1    Cumano, A.2    Muller, W.3    Di Santo, J.P.4    Vieira, P.5
  • 26
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S. and Ma, A., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998. 9: 669-676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 27
    • 0037037568 scopus 로고    scopus 로고
    • Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells
    • Judge, A. D., Zhang, X., Fujii, H., Surh, C. D. and Sprent, J., Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells. J. Exp. Med. 2002. 196: 935-946.
    • (2002) J. Exp. Med. , vol.196 , pp. 935-946
    • Judge, A.D.1    Zhang, X.2    Fujii, H.3    Surh, C.D.4    Sprent, J.5
  • 28
    • 33745808017 scopus 로고    scopus 로고
    • A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells
    • Boyman, O., Cho, J. H., Tan, J. T., Surh, C. D. and Sprent, J., A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J. Exp. Med. 2006. 203: 1817-1825.
    • (2006) J. Exp. Med. , vol.203 , pp. 1817-1825
    • Boyman, O.1    Cho, J.H.2    Tan, J.T.3    Surh, C.D.4    Sprent, J.5
  • 29
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    • Kennedy, M. K., Glaccum, M., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M., Matsuki, N. et al., Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 2000. 191: 771-780.
    • (2000) J. Exp. Med. , vol.191 , pp. 771-780
    • Kennedy, M.K.1    Glaccum, M.2    Brown, S.N.3    Butz, E.A.4    Viney, J.L.5    Embers, M.6    Matsuki, N.7
  • 30
    • 10244243681 scopus 로고    scopus 로고
    • Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis
    • Munitic, I., Williams, J. A., Yang, Y., Dong, B., Lucas, P. J., El Kassar, N., Gress, R. E. et al., Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood 2004. 104: 4165-4172.
    • (2004) Blood , vol.104 , pp. 4165-4172
    • Munitic, I.1    Williams, J.A.2    Yang, Y.3    Dong, B.4    Lucas, P.J.5    El Kassar, N.6    Gress, R.E.7
  • 31
    • 70349469577 scopus 로고    scopus 로고
    • The cunning little vixen: Foxo and the cycle of life and death
    • Hedrick, S. M., The cunning little vixen: Foxo and the cycle of life and death. Nat. Immunol. 2009. 10: 1057-1063.
    • (2009) Nat. Immunol. , vol.10 , pp. 1057-1063
    • Hedrick, S.M.1
  • 33
    • 67449168109 scopus 로고    scopus 로고
    • IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway
    • Ben Ahmed, M., Belhadj Hmida, N., Moes, N., Buyse, S., Abdeladhim, M., Louzir, H. and Cerf-Bensussan, N., IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway. J. Immunol. 2009. 182: 6763-6770.
    • (2009) J. Immunol. , vol.182 , pp. 6763-6770
    • Ben Ahmed, M.1    Belhadj Hmida, N.2    Moes, N.3    Buyse, S.4    Abdeladhim, M.5    Louzir, H.6    Cerf-Bensussan, N.7
  • 35
    • 79959534693 scopus 로고    scopus 로고
    • Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells
    • Herndler-Brandstetter, D., Landgraf, K., Jenewein, B., Tzankov, A., Brunauer, R., Brunner, S., Parson, W. et al., Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells. J. Immunol. 2011. 186: 6965-6971.
    • (2011) J. Immunol. , vol.186 , pp. 6965-6971
    • Herndler-Brandstetter, D.1    Landgraf, K.2    Jenewein, B.3    Tzankov, A.4    Brunauer, R.5    Brunner, S.6    Parson, W.7
  • 36
    • 77953318581 scopus 로고    scopus 로고
    • Stress-activated dendritic cells interact with CD4+ T cells to elicit homeostatic memory
    • Wang, Y., Seidl, T., Whittall, T., Babaahmady, K. and Lehner, T., Stress-activated dendritic cells interact with CD4+ T cells to elicit homeostatic memory. Eur. J. Immunol. 2010. 40: 1628-1638.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1628-1638
    • Wang, Y.1    Seidl, T.2    Whittall, T.3    Babaahmady, K.4    Lehner, T.5
  • 37
    • 34948910572 scopus 로고    scopus 로고
    • Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation
    • Lin, S. J., Peacock, C. D., Bahl, K. and Welsh, R. M., Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation. J. Exp. Med. 2007. 204: 2321-2333.
    • (2007) J. Exp. Med. , vol.204 , pp. 2321-2333
    • Lin, S.J.1    Peacock, C.D.2    Bahl, K.3    Welsh, R.M.4
  • 39
    • 73949111444 scopus 로고    scopus 로고
    • IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool
    • Sandau, M. M., Kohlmeier, J. E., Woodland, D. L. and Jameson, S. C., IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. J. Immunol. 2010. 184: 35-44.
    • (2010) J. Immunol. , vol.184 , pp. 35-44
    • Sandau, M.M.1    Kohlmeier, J.E.2    Woodland, D.L.3    Jameson, S.C.4
  • 40
    • 35548964302 scopus 로고    scopus 로고
    • Prevention of graft-versus-host disease by anti IL-7Ralpha antibody
    • Chung, B., Dudl, E. P., Min, D., Barsky, L., Smiley, N. and Weinberg, K. I., Prevention of graft-versus-host disease by anti IL-7Ralpha antibody. Blood 2007. 110: 2803-2810.
    • (2007) Blood , vol.110 , pp. 2803-2810
    • Chung, B.1    Dudl, E.P.2    Min, D.3    Barsky, L.4    Smiley, N.5    Weinberg, K.I.6
  • 41
    • 70349252387 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha as a potential therapeutic target in transplantation
    • Racape, M., Vanhove, B., Soulillou, J. P. and Brouard, S., Interleukin 7 receptor alpha as a potential therapeutic target in transplantation. Arch. Immunol. Ther. Exp. (Warsz) 2009. 57: 253-261.
    • (2009) Arch. Immunol. Ther. Exp. (Warsz) , vol.57 , pp. 253-261
    • Racape, M.1    Vanhove, B.2    Soulillou, J.P.3    Brouard, S.4
  • 42
    • 46949105036 scopus 로고    scopus 로고
    • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    • Sportes, C., Hakim, F. T., Memon, S. A., Zhang, H., Chua, K. S., Brown, M. R., Fleisher, T. A. et al., Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 2008. 205: 1701-1714.
    • (2008) J. Exp. Med. , vol.205 , pp. 1701-1714
    • Sportes, C.1    Hakim, F.T.2    Memon, S.A.3    Zhang, H.4    Chua, K.S.5    Brown, M.R.6    Fleisher, T.A.7
  • 43
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. and Murray, R., Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 1995. 181: 1519-1526.
    • (1995) J. Exp. Med. , vol.181 , pp. 1519-1526
    • von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 45
    • 65349131915 scopus 로고    scopus 로고
    • ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
    • Soriani, A., Zingoni, A., Cerboni, C., Iannitto, M. L., Ricciardi, M. R., Di Gialleonardo, V., Cippitelli, M. et al., ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 2009. 113: 3503-3511.
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1    Zingoni, A.2    Cerboni, C.3    Iannitto, M.L.4    Ricciardi, M.R.5    Di Gialleonardo, V.6    Cippitelli, M.7


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