Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy

AIDS

Volumn 24, Issue 16, 2010, Pages 2590-2593

  Bai, Francesca ^a   Bellistrí, Giusi M ^a   Tincati, Camilla ^a   Savoldi, Alessia ^a   Pandolfo, Alessandro ^a   Bini, Teresa ^a   Carpani, Giovanni ^b   Sinigaglia, Elisabetta ^b   Marchetti, Giuliá ^a   Monforte, Antonella D'Arminio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN PAOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RO ANTIGEN; FAS ANTIGEN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RITONAVIR;

ADULT; APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CONVALESCENCE; DOWN REGULATION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 78549287788     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833f9d64     Document Type: Article

References (15)

1. + T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps and therapeutic options. Clin Infect Dis 2009; 48:328-337.
2. + T-cells despite suppression of HIV replication under HAART. AIDS Rev 2006; 8:88-97.
3. Collazos J, Asensi V, Cartoon JA, Grupo Espanol para el Estudio Multifactorial de la Adherencia (Geema). CD4 responses in the setting or suboptimal virological responses to antiretroviral therapy: features, outcomes, and associated factors. AIDS Res Hum Retrovirus 2009; 25:647-655.
4. Collazos J, Asensi V, Cartoon JA, Grupo Espanol para el Estudio Multifactorial de la Adherencia (Geema). Factors associated with poor immunological responses despite viral suppression in markedly immunosuppressed patients. AIDS Patient Care and STDs 2007;21:378-384.
5. Sabin CA, Colette JS, Gumley H, Murphy G, Lampe FC, Phillips AN, et al. Late presenters in the era of highly active antire- troviral therapy: uptake of and responses to antiretroviral therapy. AIDS 2004; 18:2145-2151 .
6. Mussini C, Manzardo C, Johnson M, d'Arminio Monforte A, Uberti-Foppa C, Antinori A, et al. Patients presenting with AIDS in the HAART era: a collaborative cohort analysis. AIDS 2008; 22:2461-2469.
7. Battegay M, FehrJ, Fluchiger U, Elzi L. Antiretroviral therapy of late presenters with advanced HIV disease. JAntimicrob Che-mother 2008;62:41-44.
8. Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, Grimes HL, Singer A. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004; 21:289-302.
9. Juffroy O, Bugault F, Lambotte O, Landires I, Viard JP, Niel L, et al. Dual mechanism of impairment of Interleukin-7 (IL-7) responses in Human Immunodeficiency Virus Infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J Virol 2010;84:96-108.
10. + T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression. J Infect Dis 2009;199:1872-1882.
11. + T cell gains in Human Immunodeficiency Virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003;187:1534-1543.
12. Savarino A, Bottarel F, Malavasi F, Dianzani U. Roleof CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions? AIDS 2000;14:1079-1089.
13. Benito JM, Lopez M, Lozano S, Ballesteros C, Martinez P, Gonzalez-Lahoz J, Soriano V. Differential upregulation of CD38 on different T-cell subset may influence the ability to reconstitute CD4 T cells under successful highly active anti-retroviral therapy. J AIDS 2005;38:373-381.
14. + cells after antiretroviral therapy. J Infect Dis 2008;198:1466-1473.
15. + T-cell pool, immune activation and inflammation. Topics HIV Med 2010;18:2-6.