In vivo evaluation of PhiC31 recombinase activity in transgenic mice

Neuroscience Research

Volumn 73, Issue 2, 2012, Pages 106-114

  Imayoshi, Itaru ^a,b   Hirano, Kyoko ^a,c   Kitano, Satsuki ^a   Miyachi, Hitoshi ^a   Kageyama, Ryoichiro ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Nestin; PhiC31 recombinase; PhiC31 ER T2; Transgenic mice; Tyrosine hydroxylase

Indexed keywords

ESTROGEN RECEPTOR; PHIC31 RECOMBINASE; RECOMBINASE; TAMOXIFEN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; CATECHOLAMINE NERVE CELL; CODON; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE CASSETTE; GENETIC RECOMBINATION; IN VIVO STUDY; LIGAND BINDING; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STEM CELL; STREPTOMYCES; TRANSGENIC MOUSE; ANIMAL; ENZYME ACTIVATION; ENZYMOLOGY; EVALUATION; GENETIC ENGINEERING; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; STANDARD;

ANIMALS; BACTERIOPHAGES; ENZYME ACTIVATION; FEMALE; GENETIC ENGINEERING; MALE; MICE; MICE, TRANSGENIC; NEURAL STEM CELLS; RECOMBINASES; RECOMBINATION, GENETIC;

EID: 84860335327     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.02.008     Document Type: Article

References (31)

1. Andreas S., Schwenk F., Kuter-Luks B., Faust N., Kuhn R. Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. Nucleic Acids Res. 2002, 30:2299-2306.
2. Belteki G., Gertsenstein M., Ow D.W., Nagy A. Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat. Biotechnol. 2003, 21:321-324.
3. Branda C.S., Dymecki S.M. Talking about a revolution: the impact of site-specific recombinases on genetic analysis in mice. Dev. Cell 2004, 6:7-28.
4. Chalberg T.W., Portlock J.L., Olivares E.C., Thyagarajan B., Kirby P.J., Hillman R.T., Hoelters J., Calos M.P. Integration specificity of phage phiC31 integrase in the human genome. J. Mol. Biol. 2006, 357:28-48.
5. Czyzyk-Krzeska M.F., Beresh J.E. Characterization of the hypoxia-inducible protein binding site within the pyrimidine-rich tract in the 3'-untranslated region of the tyrosine hydroxylase mRNA. J. Biol. Chem. 1996, 271:3293-3299.
6. Ehrhardt A., Xu H., Huang Z., Engler J.A., Kay M.A. A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of bacteriophage integrase phiC31 and the Sleeping Beauty transposase. Mol. Ther. 2005, 11:695-706.
7. Feil R., Wagner J., Metzger D., Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem. Biophys. Res. Commun. 1997, 237:752-757.
8. Grindley N.D., Whiteson K.L., Rice P.A. Mechanisms of site-specific recombination. Annu. Rev. Biochem. 2006, 75:567-605.
9. Groth A.C., Olivare s E.C., Thyagarajan B., Calos M.P. A phage integrase directs efficient site-specific integration in human cells. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5995-6000.
10. Imayoshi I., Ohtsuka T., Metzger D., Chambon P., Kageyama R. Temporal regulation of Cre recombinase activity in neural stem cells. Genesis 2006, 44:233-238.
11. Imayoshi I., Sakamoto M., Ohtsuka T., Takao K., Miyakawa T., Yamaguchi M., Mori K., Ikeda T., Itohara S., Kageyama R. Roles ofcontinuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat. Neurosci. 2008, 11:1153-1161.
12. Imayoshi I., Sakamoto M., Kageyama R. Genetic methods to identify and manipulate newly born neurons in the adult brain. Front. Neurosci. 2011, 5:64. 10.3389/fnins.2011.00064.
13. Iwawaki T., Kohno K., Kobayashi K. Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells. Biochem. Biophys. Res. Commun. 2000, 274:590-595.
14. Kriegstein A., Alvarez-Buylla A. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci. 2009, 32:149-184.
15. Lagace D.C., Whitman M.C., Noonan M.A., Ables J.L., DeCarolis N.A., Arguello A.A., Donovan M.H., Fischer S.J., Farnbauch L.A., Beech R.D., DiLeone R.J., Greer C.A., Mandyam C.D., Eisch A.J. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J. Neurosci. 2007, 27:12623-12629.
16. Lendahl U., Zimmerman L.B., McKay R.D.G. CNS stem cells express a new class of intermediate filament protein. Cell 1990, 60:585-595.
17. Lindeberg J., Usoskin D., Bengtsson H., Gustafsson A., Kylberg A., Soederstroem S., Ebendal T. Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus. Genesis 2004, 40:67-73.
18. Liu J., Jeppesen I., Nielsen K., Jensen T.G. PhiC31 integrase induces chromosomal aberrations in primary human fibroblasts. Gene Ther. 2006, 13:1188-1190.
19. Matsuda T., Cepko C.L. Controlled expression of transgenes introduced by in vivo electroporation. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:1027-1032.
20. Matsushita N., Okada H., Yasoshima Y., Takahashi K., Kiuchi K., Kobayashi K. Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J. Neurochem. 2002, 82:295-304.
21. Mignone J.L., Kukekov V., Chiang A., Steindler D., Enikolopov G. Neural stem and progenitor cells in nestin-GFP transgenic mice. J. Comp. Neurol. 2004, 469:311-324.
22. Min N., Joh T.H., Kim K.S., Peng C., Son J.H. 5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Mol. Brain Res. 1994, 27:281-289.
23. Nagy A. Cre recombinase: the universal reagent for genome tailoring. Genesis 2000, 26:99-109.
24. Ohsawa R., Ohtsuka T., Kageyama R. Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. J. Neurosci. 2005, 25:5857-5865.
25. Rausch H., Lehmann M. Structural analysis of the actinophage phiC31 attachment site. Nucleic Acids Res. 1991, 19:5187-5189.
26. Raymond C.S., Soriano P. High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS ONE 2007, 2:e162.
27. Sangiorgi E., Shuhua Z., Capecchi M.R. In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette. Nucleic Acids Res. 2008, 36:e134.
28. Sharma N., Moldt B., Dalsgaatd T., Jensen T.G., Mikkelsen J.G. Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res. 2008, 36:e67.
29. Thorpe H.M., Wilson S.E., Smith M.C. Control of directionality in the site-specific recombination system of the Streptomyces phage phiC31. Mol. Microbiol. 2000, 38:232-241.
30. Wu S., Ying G., Wu Q., Capecchi M.R. Toward simpler and faster genome-wide mutagenesis in mice. Nat. Genet. 2007, 39:922-930.
31. Zimmerman L., Lendahl U., Cunningham M., McKay R., Parr B., Gavin B., Mann J., Vassileva G., McMahon A. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursoprs. Neuron 1994, 12:11-24.