Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA

Journal of Bacteriology

Volumn 194, Issue 7, 2012, Pages 1823-1834

  Truong Bolduc, Que Chi ^a   Hsing, Liao Chun ^a,c   Villet, Regis ^a   Bolduc, Gilles R ^b   Estabrooks, Zoe ^b   Florent Taguezem, G ^b   Hooper, David C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Massasoit Community College   (United States)

^c FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; HYDROGEN PEROXIDE; MGRA PROTEIN; MOXIFLOXACIN; NORB PROTEIN; OXYGEN; SERINE PROTEINASE; UNCLASSIFIED DRUG; NITRIC OXIDE REDUCTASE; NITRIC-OXIDE REDUCTASE; OXIDOREDUCTASE;

AERATION; ANTIBIOTIC SENSITIVITY; ARTICLE; DIMERIZATION; DNA BINDING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; STAPHYLOCOCCUS AUREUS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; STAPHYLOCOCCUS INFECTION;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; OXIDOREDUCTASES; OXYGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84860330756     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.06503-11     Document Type: Article

References (30)

1. Ballal A, Manna AC. 2009. Expression of the sarA family of genes in different strains of Staphylococcus aureus. Microbiology 155:2342-2352.
2. Ballal A, Ray B, Manna AC. 2009. sarZ, a sarA family gene, is transcriptionally activated by MgrA and is involved in the regulation of genes encoding exoproteins in Staphylococcus aureus. J. Bacteriol. 191:1656-1665.
3. Carter P, Wells JA. 1988. Dissecting the catalytic triad of a serine protease. Nature 332:564-568.
4. Chen H, et al. 2008. The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism. Proc. Natl. Acad. Sci. U. S. A. 105:13586-13591.
5. Chen PR, et al. 2006. An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat. Chem. Biol. 2:591-595.
6. Cramton SE, Ulrich M, Götz F, Döring G. 2001. Anaerobic conditions induce expression of polysaccharide intercellular adhesin in Staphylococcus aureus and Staphylococcus epidermidis. Infect. Immun. 69:4079-4085.
7. Ding Y, Onodera Y, Lee JC, Hooper DC. 2008. NorB, an efflux pump in Staphylococcus aureus MW2, contributes to bacterial fitness in abscesses. J. Bacteriol. 190:7123-7129.
8. Frees D, Sørensen K, Ingmer H. 2005. Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network. Infect. Immun. 73:8100-8108.
9. Fuchs S, Pané-Farré J, Kohler C, Hecker M, Engelmann S. 2007. Anaerobic gene expression in Staphylococcus aureus. J. Bacteriol. 189: 4275-4289.
10. Kashket ER. 1981. Proton motive force in growing Streptococcus lactis and Staphylococcus aureus cells under aerobic and anaerobic conditions. J. Bacteriol. 146:376.
11. Maruyama A, et al. 2003. Oxidative-stress-inducible qorA encodes an NADPH-dependent quinone oxidoreductase catalysing a one-electron reduction in Staphylococcus aureus. Microbiology 149:389-398.
12. Michel A, et al. 2006. Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair. J. Bacteriol. 188:5783-5796.
13. Neitzel JJ. 2010. Enzyme catalysis: the serine proteases. Nat. Educ. 3:21-25.
14. Pagels M, et al. 2010. Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol. Microbiol. 76:1142-1161.
15. Park B, Nizet V, Liu GY. 2008. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J. Bacteriol. 190: 2275-2278.
16. Poor CB, Chen PR, Duguid E, Rice PA, He C. 2009. Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus. J. Biol. Chem. 284:23517-23524.
17. Reed SB, et al. 2001. Molecular characterization of a novel Staphylococcus aureus serine protease operon. Infect. Immun. 69:1521-1527.
18. Ross RA, Onderdonk AB. 2000. Production of toxic shock syndrome toxin 1 by Staphylococcus aureus requires both oxygen and carbon dioxide. Infect. Immun. 68:5205-5209.
19. Schlag S, et al. 2008. Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J. Bacteriol. 190:7847-7858.
20. Throup JP, et al. 2001. The srhSR gene pair from Staphylococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function. Biochemistry 40:10392-10401.
21. Trotonda MP, Tamber S, Memmi G, Cheung AL. 2008. MgrA represses biofilm formation in Staphylococcus aureus. Infect. Immun. 76:5645-5654.
22. Truong-Bolduc QC, et al. 2011. Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin. Antimicrob. Agents Chemother. 55:3214-3219.
23. Truong-Bolduc QC, Ding Y, Hooper DC. 2008. Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus. J. Bacteriol. 190:7375-7381.
24. Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC. 2005. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J. Bacteriol. 187:2395-2405.
25. Truong-Bolduc QC, Hooper DC. 2010. Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus. J. Bacteriol. 192:2525-2534.
26. Truong-Bolduc QC, Strahilevitz J, Hooper DC. 2006. NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. Antimicrob. Agents Chemother. 50:1104-1107.
27. Truong-Bolduc QC, Zhang X, Hooper DC. 2003. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. J. Bacteriol. 185:3127-3138.
28. Weinrick B, et al. 2004. Effect of mild acid on gene expression in Staphylococcus aureus. J. Bacteriol. 186:8407-8423.
29. Worlitzsch D, et al. 2001. Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo. Antimicrob. Agents Chemother. 45:196-202.
30. Yarwood JM, Schlievert PM. 2000. Oxygen and carbon dioxide regulation of toxic shock syndrome toxin 1 production by Staphylococcus aureus MN8. J. Clin. Microbiol. 38:1797-1803.