LDP12, a novel cell-permeable peptide derived from L1 capsid protein of the human papillomavirus

Molecular Biology Reports

Volumn 39, Issue 2, 2012, Pages 1079-1086

  Lee, Jong Eun ^a   Lim, Hyunjung Jade ^a  

^a Konkuk University   (South Korea)

Author keywords

Cell permeable peptide; Endocytosis; LDP12; Protein cargo; Uterus

Indexed keywords

BETA CYCLODEXTRIN; CAPSID PROTEIN; CARRIER PROTEIN; THREONYLALANYLPROLYLLYSYLPROLYLLYSYLTHREONYLLYSYLTHREONYLLYSYLLYSINE PEPTIDE; UNCLASSIFIED DRUG; 5 BROMO 4 CHLORO 3 INDOLYL BETA GALACTOSIDE; 5-BROMO-4-CHLORO-3-INDOLYL BETA-GALACTOSIDE; BETA CYCLODEXTRIN DERIVATIVE; BETA GALACTOSIDASE; CELL PENETRATING PEPTIDE; FLUORESCEIN ISOTHIOCYANATE; GALACTOSIDE; INDOLE DERIVATIVE; L1 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 11; METHYL BETA CYCLODEXTRIN; METHYL-BETA-CYCLODEXTRIN; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; LIPID RAFT; MAMMAL CELL; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN TRANSPORT; RAT; TEMPERATURE SENSITIVITY; WART VIRUS; ANIMAL; CHO CELL; CONFOCAL MICROSCOPY; CRICETULUS; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HAMSTER; HUMAN PAPILLOMAVIRUS TYPE 11; METABOLISM; METHODOLOGY; NERVE CELL; PROTEIN ENGINEERING; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; VIRUS ENTRY; WESTERN BLOTTING;

HUMAN PAPILLOMAVIRUS; MAMMALIA; MIRIDAE; RATTUS;

ANIMALS; BETA-CYCLODEXTRINS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CAPSID PROTEINS; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; CHO CELLS; CRICETINAE; CRICETULUS; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE; GALACTOSIDES; HUMAN PAPILLOMAVIRUS 11; HUMANS; INDOLES; MICE; MICROSCOPY, CONFOCAL; NEURONS; ONCOGENE PROTEINS, VIRAL; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; VIRUS INTERNALIZATION;

EID: 84860330708     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0834-y     Document Type: Article

References (27)

1. Jarver P, Langel U (2004) The use of cell-penetrating peptides as a tool for gene regulation. Drug Discov Today 9:395-402 (Pubitemid 38479684)
2. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569-1572 (Pubitemid 29420581)
3. Wadia JS, Dowdy SF (2002) Protein transduction technology. Curr Opin Biotechnol 13:52-56 (Pubitemid 34146548)
4. Wadia JS, Dowdy SF (2003) Modulation of cellular function by TAT mediated transduction of full length proteins. Curr Protein Pept Sci 4:97-104 (Pubitemid 36834009)
5. Zhang MX, Li ZH, Fang YX, Zhu HZ, Xue JL, Chen JZ, Jia W (2009) TAT-phiC31 integrase mediates DNA recombination in mammalian cells. J Biotechnol 142:107-113
6. Pan C, Lu B, Chen H, Bishop CE (2010) Reprogramming human fibroblasts using HIV-1 TAT recombinant proteins OCT4, SOX2, KLF4 and c-MYC. Mol Biol Rep 37:2117-2124
7. Choi JM, Ahn MH, Chae WJ, Jung YG, Park JC, Song HM, Kim YE, Shin JA, Park CS, Park JW, Park TK, Lee JH, Seo BF, Kim KD, Kim ES, Lee DH, Lee SK, Lee SK (2006) Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat Med 12:574-579
8. Morris MC, Depollier J, Mery J, Heitz F, Divita G (2001) A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol 19:1173-1176 (Pubitemid 33115705)
9. Weller K, Lauber S, Lerch M, Renaud A, Merkle HP, Zerbe O (2005) Biophysical and biological studies of end-group-modified derivatives of Pep-1. Biochemistry 44:15799-15811 (Pubitemid 41746911)
10. Morris MC, Vidal P, Chaloin L, Heitz F, Divita G (1997) A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res 25:2730-2736 (Pubitemid 27299785)
11. Fittipaldi A, Ferrari A, Zoppe M, Arcangeli C, Pellegrini V, Beltram F, Giacca M (2003) Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J Biol Chem 278:34141-34149 (Pubitemid 37553255)
12. Nakase I, Niwa M, Takeuchi T, Sonomura K, Kawabata N, Koike Y, Takehashi M, Tanaka S, Ueda K, Simpson JC, Jones AT, Sugiura Y, Futaki S (2004) Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Mol Ther 10:1011-1022 (Pubitemid 39625245)
13. Wadia JS, Stan RV, Dowdy SF (2004) Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 10:310-315 (Pubitemid 38667624)
14. Fretz MM, Penning NA, Al-Taei S, Futaki S, Takeuchi T, Nakase I, Storm G, Jones AT (2007) Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34? leukaemia cells. Biochem J 403:335-342 (Pubitemid 46596590)
15. Gerbal-Chaloin S, Gondeau C, drian-Herrada G, Heitz F, Gau-thier-Rouviere C, Divita G (2007) First step of the cell-penetrating peptide mechanism involves Rac1 GTPase-dependent actin-network remodelling. Biol Cell 99:223-238 (Pubitemid 46567179)
16. Kwon SJ, Han K, Jung S, Lee JE, Park S, Cheon YP, Lim HJ (2009) Transduction of the MPG-tagged fusion protein into mammalian cells and oocytes depends on amiloride-sensitive endocytic pathway. BMC Biotechnol 9:73
17. Joyce JG, Tung JS, Przysiecki CT, Cook JC, Lehman ED, Sands JA, Jansen KU, Keller PM (1999) The L1 major capsid protein of human papillomavirus type 11 recombinant viruslike particles interacts with heparin and cell-surface glycos-aminoglycans on human keratinocytes. J Biol Chem 274: 5810-5822 (Pubitemid 29109237)
18. Sasagawa T, Pushko P, Steers G, Gschmeissner SE, Hajibagheri MA, Finch J, Crawford L, Tommasino M (1995) Synthesis and assembly of virus-like particles of human papillomaviruses type 6 and type 16 in fission yeast Schizosaccharomyces pombe. Virology 206:126-135
19. Windram OP, Weber B, Jaffer MA, Rybicki EP, Shepherd DN, Varsani A (2008) An investigation into the use of human papil-lomavirus type 16 virus-like particles as a delivery vector system for foreign proteins: N- and C-terminal fusion of GFP to the L1 and L2 capsid proteins. Arch Virol 153:585-589
20. Hindmarsh PL, Laimins LA (2007) Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry. Virol J 4:19
21. Lee HJ, Khoshaghideh F, Patel S, Lee SJ (2004) Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 24:1888-1896 (Pubitemid 38292800)
22. Kameyama S, Horie M, Kikuchi T, Omura T, Tadokoro A, Takeuchi T, Nakase I, Sugiura Y, Futaki S (2007) Acid wash in determining cellular uptake of Fab/cell-permeating peptide conjugates. Biopolymers 88:98-107 (Pubitemid 46657975)
23. Becker-Hapak M, McAllister SS, Dowdy SF (2001) TAT-mediated protein transduction into mammalian cells. Methods 24: 247-256 (Pubitemid 32846431)
24. Nagy A, Gertsenstein M, Vintersten K, Behringer R (2003) Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
25. Conner SD, Schmid SL (2003) Regulated portals of entry into the cell. Nature 422:37-44 (Pubitemid 36323287)
26. West MA, Bretscher MS, Watts C (1989) Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J Cell Biol 109:2731-2739 (Pubitemid 20011900)
27. Hao M, Mukherjee S, Sun Y, Maxfield FR (2004) Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes. J Biol Chem 279:14171-14178 (Pubitemid 38468954)